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Omeros Announces Discovery in MASP-2 Program
Date:7/31/2012

on of this protein and/or MASP-2.

"The discovery of the mechanism that directs alternative pathway activation has recharted our understanding of the complement system and answered one of the remaining questions about its role in the inflammatory response," said Dr. Wilhelm Schwaeble, Professor of Immunology at the University of Leicester and Royal Society-Wolfson Research Merit Award Holder. "This new paradigm could lead to improved therapies to treat complement-mediated disorders."

Omeros' MASP-2 program has been focused on the development of antibodies that target MASP-2 and its unique role in the activation of the lectin pathway. The Company has conducted a series of in vivo studies that suggest that MASP-2 inhibition may have a preventive or therapeutic effect in the treatment of hemolytic uremic syndrome (HUS), atypical HUS (aHUS), paroxysmal nocturnal hemoglobinuria (PNH), wet age-related macular degeneration (AMD), ischemia-reperfusion injury, transplant-related complications and other immune-related disorders.

"In parallel with our MASP-2 program initially targeting aHUS, Omeros is now advancing the development of antibodies that would block activation of the lectin and alternative pathways to treat inflammatory disorders linked to both," said Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "These antibodies are expected to be delivered by a single subcutaneous or intramuscular injection and, equally important, to not interfere with the classical pathway – a critical component of the acquired immune response to infection. We expect the same advantages with our MASP-2 antibody, and our team is working hard to move that product into the clinic in the first part of 2013."

About Omeros' MASP-2 Program

MASP-2 is a novel pro-inflammatory protein target involved in activation of the complement system, which is an important component of the immune system. The complement system plays a role
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