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Omeros Announces Discovery in MASP-2 Program
Date:7/31/2012

SEATTLE, July 31, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it believes it has identified the proteins that activate the alternative pathway of the complement system, an important part of the immune system.  The work was led by the Company's collaborator, Professor Wilhelm Schwaeble of the University of Leicester, and Omeros controls the worldwide exclusive rights to this discovery. The complement system plays an important role in the inflammatory response and becomes activated as a result of tissue damage or microbial infection. The discovery announced today further expands Omeros' mannan-binding lectin associated serine protease-2 (MASP-2) program and may permit the development of new antibodies to treat disorders that involve alternative pathway activation.

The complement system can be activated through the following three distinct pathways: the classical, lectin and alternative.  The classical pathway is part of the acquired immune system while the lectin and alternative pathways are part of the innate immune system.  In contrast to the classical and lectin pathways, no specific recognition molecules had previously been identified to drive complement activation via the alternative pathway.

In connection with his research for the MASP-2 program, Omeros collaborator Professor Schwaeble has now identified the proteins that drive activation of the alternative pathway.  In addition to advancing Omeros' MASP-2 program, this discovery is expected to lead to new therapeutics targeting disorders linked to the alternative pathway. Omeros has recently filed a series of patent applications that claim a broad intellectual property position related to this new discovery, potential therapeutics targeting this protein alone or in conjunction with MASP-2, and a host of inflammatory disease indications linked to the inhibiti
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