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Omeros Adds Four More Unlocked Orphan GPCRs to its Portfolio
Date:5/3/2012

SEATTLE, May 3, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced that it has identified compounds that functionally interact with each of four additional orphan G protein-coupled receptors (GPCRs). Without compounds that functionally interact with orphan GPCRs, developing drugs targeting those receptors is extremely difficult. Omeros has now unlocked 37 of them, representing over 45 percent of the Class A orphan GPCRs. There are approximately 120 orphan GPCRs and Omeros expects to unlock a large percentage of them, focusing first on Class A orphan GPCRs.

The four additional orphan GPCRs unlocked by Omeros are GPR83, GPR150, GPR151 and GPR183. GPR83 has been implicated in memory, stress and control of emotions and is also associated with autoimmune and inflammatory diseases. GPR150 is linked to ovarian cancer, while GPR151 is involved with cognition. GPR183 is an important component of the immune system and plays a central role in controlling B-cell migration and T-cell-dependent antibody production. Omeros is in the process of filing broad patent applications around its unlocked orphan GPCRs and compound optimization efforts are in progress.

"Our GPCR program currently remains focused on rapidly unlocking orphan receptors and uniquely elucidating their respective signaling profiles, and our successes continue to mount," said Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "The data generated by this approach enable medicinal chemistry to develop potential therapeutics and feed directly into our primary patent objective – to exclusively control each receptor that we unlock together with the compounds that functionally interact with it."

Ongoing GPCR Program

Omeros is screening orphan GPCRs against its small-molecule chemical libraries using its proprietary, high-throughput cellular redist
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SOURCE Omeros Corporation
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