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Omega-3 Supplements Show Promise in Alleviating Depression
Date:12/7/2010

MIAMI, Dec. 8, 2010 /PRNewswire-USNewswire/ -- A new analysis of the effects of omega-3 essential fatty acids offers the hope of enhanced treatment options for tens of millions of people with depression. Two critical omega-3 essential fatty acids available from certain food or nutritional supplements but not manufactured by the body—Eicosapentenoic acid (EPA) and docosahexaenoic (DHA) — play a role in optimal brain functioning and have antidepressant benefits that have not been fully recognized.  The results were presented today at the annual meeting of the American College of Neuropsychopharmacology.

In a meta-analysis of 15 randomized, double-blind, placebo-controlled studies, researchers from the University of Illinois at Chicago, led by John M. Davis, M.D., research professor at the University of Illinois at Chicago and ACNP member, found that patients taking omega-3 with either EPA or a combination of EPA and DHA experienced clear antidepressant benefits. However, across studies, patients taking the pure DHA form of omega-3 saw no antidepressant effect.

"Our analysis clarifies the precise type of omega-3 fatty acid that is effective for people with depression and explains why previous findings have been contradictory," said Davis. "The EPA predominant formulation is necessary for the therapeutic action to occur. The DHA predominant formulation does not have antidepressant efficacy."

While scientists noted that omega-3 produces beneficial effects in patients with depression, EPA does not improve mood in people who are not depressed. In several studies, people without depression experienced no difference in mood as a result of omega-3 consumption. In another study Davis and his team found that women with inadequate omega-3 intake were more likely to experience depression during and after pregnancy than women with adequate omega-3 in their diets.

"The findings are unambiguous," said Davis. "Omega-3 fatty acids have
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SOURCE American College of Neuropsychopharmacology
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