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Olodaterol Shows Sustained Improvements in Lung Function in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Date:9/8/2013

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0.101 L
(P < 0.0001)

0.143 L
(P < 0.0001)

0.048 L
(P < 0.01)In a second set of 48-week studies (NCT00793624 and NCT00796653), the same dose and delivery of olodaterol provided comparable improvements in lung function compared to 12 mcg formoterol twice daily in these COPD patients (n=904 and 934). After 24 weeks of treatment, both doses of olodaterol and formoterol provided statistically significant improvements in FEV1 AUC0-3.Study 1

Study 2Adjusted mean FEV1

 AUC0-3 difference

from placebo

Adjusted mean trough

 FEV1 difference

 from placebo

Adjusted mean FEV1

 AUC0-3 difference

 from placebo

Adjusted mean trough

 FEV1 difference

 from placeboOlodaterol

5

 mcg

0.15 L
(P < 0.0001)

0.08 L
(P < 0.001)

0.13 L
(P < 0.0001)

0.05 L
(P < 0.01)Olodaterol

10

 mcg

0.17 L
(P < 0.0001)

0.09 L
(P < 0.0001)

0.15 L
(P < 0.0001)

0.07 L
(P < 0.001)Formoterol

12

mcg

0.18 L
(P < 0.0001)

0.05 L
(P < 0.01)

0.15 L
(P < 0.0001)

0.04 L
(P < 0.05)Olodaterol 5 mcg was shown to provide significant improvement (P < 0.0001) in lung function within five minutes following the first dose.

In addition, COPD patients had less need for both day- and night-time rescue medication when using both doses of olodat
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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