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Olodaterol Shows Sustained Improvements in Lung Function in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Date:9/8/2013

the more than 20 presentations from the Boehringer Ingelheim lung health portfolio being presented at this year's ERS Congress, five are from the Phase 3 olodaterol clinical program.

"We are encouraged by these findings and have an ongoing commitment to bringing new treatment options to patients with COPD," said Tunde Otulana, MD, senior vice president, Clinical Development and Medical Affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "Our leadership role in lung health is driven by our heritage and passion for finding ways to address the unmet needs of the millions of Americans living with debilitating lung diseases such as COPD."

Key Results from the 48-Week Phase 3 Olodaterol Studies 
In one set of 48-week Phase 3 pivotal studies (NCT00782210 and NCT00782509), olodaterol 5 and 10 mcg delivered once daily via the Respimat® inhaler provided statistically significant improvements in lung function, as measured by FEV1, versus placebo plus usual care in patients with moderate to very severe COPD (P < 0.05; n=613 and 635). Study 1

Study 2Adjusted mean FEV1

 AUC0-3 difference

from placebo

Adjusted mean trough

 FEV1 difference

 from placebo

Adjusted mean FEV1

 AUC0-3 difference

 from placebo

Adjusted mean trough

 FEV1 difference

from placeboOlodaterol

5

 mcg

0.172 L
(P < 0.0001)

0.091 L
(P < 0.0001)

0.151 L
(P < 0.0001)

0.047 L
(P < 0.05)Olodaterol

10

mcg

0.176 L
(P < 0.0001)<
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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