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Olodaterol Shows Sustained Improvements in Lung Function in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
Date:9/8/2013

RIDGEFIELD, Conn., Sept. 8, 2013 /PRNewswire/ -- Data from the olodaterol Phase 3 clinical program, presented for the first time at the European Respiratory Society (ERS) Annual Congress 2013 in Barcelona, showed the addition of olodaterol 5 and 10 mcg delivered once daily via the Respimat® inhaler provided improvements in lung function in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). Olodaterol is an investigational long-acting beta agonist (LABA) currently being studied as a once-daily maintenance bronchodilator treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema.

These data are from two sets of replicate, 48-week pivotal studies evaluating the long-term efficacy and safety of once-daily olodaterol in 5 and 10 mcg doses, as well as two sets of replicate, 6-week studies investigating olodaterol's 24-hour bronchodilation profile. In an effort to more accurately represent the clinical practice setting, patients involved in the Phase 3 program were allowed to continue their usual care, with the exception of LABAs. Usual care included long- and short-acting anticholinergics, short-acting beta agonists, inhaled corticosteroids (ICS) and xanthines.

"Despite advances in the treatment of COPD, there remains a significant need to reduce the burden of COPD on patients' lives," said lead study author Gary T. Ferguson, MD, of the Pulmonary Research Institute of Southeast Michigan, Livonia, Michigan. "We are excited about these data because we see that the lung function improvements shown with olodaterol may translate into patient-related benefits over and above those seen with usual care, and these improvements on top of permitted bronchodilator therapies makes these positive results even more noteworthy."

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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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