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Ohr Pharmaceutical Announces Additions to Ophthalmic Scientific Advisory Board
Date:11/20/2012

d ASRS Honor award. Dr. Roth was elected by his peers for inclusion in Best Doctors in America® and in the Guide to America's Top Ophthalmologists®.  He has been a Principal Investigator for many clinical trials and sits on the committee for continuing medical education at the medical school. Dr. Roth has written chapters for numerous medical textbooks, and his research on eye disease has been published in many peer-reviewed medical journals.

About Squalamine Eye Drops

Squalamine is an anti-angiogenic small molecule with a novel intracellular mechanism of action, which counteracts not only Vascular Endothelial Growth Factor ("VEGF"), but also other angiogenic growth factors such as Platelet Derived Growth Factor ("PDGF"). Recent clinical evidence has shown PDGF to be an additional key target for the treatment of wet-AMD. The drug was previously studied using an intravenous administration in over 250 patients in Phase I and Phase II trials for the treatment of wet-AMD, with squalamine demonstrating favorable biological effect and maintained and improved visual acuity outcomes, with both early and advanced lesions responding. Ohr Pharmaceutical has developed a novel eye drop of Squalamine for the treatment of wet-AMD designed for self-administration which may provide several potential advantages over the FDA approved current standards of care, Roche/Genentech's Lucentis® and Regeneron's Eylea®, which require intravitreal injections directly into the eye. Preclinical testing has demonstrated that the eye drop formulation is both safe to ocular tissues and achieves in excess of target anti-angiogenic concentrations in the tissues of the back of the eye. In May 2012, the Squalamine Eye Drop program was granted Fast Track Designation by the U.S. FDA. A Phase II randomized, double blind, placebo controlled study to evaluate the efficacy and safety of Squalamine Eye Drops for the treatment of wet-AMD was initiated in September 2012.'/>"/>

SOURCE Ohr Pharmaceutical Inc.
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