Navigation Links
Ocular Therapeutix Commences Pilot Phase II Travoprost Punctum Plug Study for the Treatment of Glaucoma
Date:8/20/2012

BEDFORD, Mass., Aug. 20, 2012 /PRNewswire/ -- Following encouraging results from Ocular Therapeutix's travoprost punctum plug feasibility study, the company is now entering a pilot Phase II clinical trial to examine a two-month sustained release drug (OTX-TP2) for the treatment of ocular hypertension and glaucoma. Ocular Therapeutix's travoprost punctum plugs are inserted into the proximal nasolacrimal canal, and release drug to the ocular surface over the two-month treatment period.

The initial travoprost punctum plug feasibility study, conducted at the Singapore National Eye Center and the National University Hospital in Singapore, examined efficacy of the technology over a 1-month duration. "Having demonstrated proof of concept in our feasibility study, we have extended the length of drug delivery to two months for the pilot Phase II trial," stated Amar Sawhney, Ph.D., President and CEO of Ocular Therapeutix, Inc.  "Extending treatment duration for the disease is a key milestone for our company's path to commercialization."

The pilot Phase II study will enroll twenty patients (up to 40 eyes) at the Umhlanga Hospital Medical Centre and Netcare Alberlito Hospital in South Africa.  Patients with documented ocular hypertension or open-angle glaucoma, the most common form of the disease, will be evaluated for reduction of intraocular pressure from baseline and retention of the plug through two months.  Elevated intraocular pressure is the most important risk factor for glaucoma.

Glaucoma is a chronic disease which must be monitored and treated for life, impacting more than 2 million Americans, and represents a $5 billion market worldwide.  The current mode of treatment for the disease is topical prescription drops which must be taken daily and at regular intervals to prevent progression of the disease.  However, topical prescriptions are plagued with issues of non-compliance, which can lead to costly and invasive surgeries, vision impairment, and even blindness.  It has been reported that up to 60% of patients do not administer ophthalmic drops as directed, even though patients' perception is that they are compliant with 97% of their dosing.1

"Travoprost Punctum Plugs may help to overcome issues of daily self-administration of medication leading to potential patient non-compliance," stated Pierre Wassermann, Principal Investigator at the Umhlanga Hospital Medical Centre in South Africa.  "Additionally, maintaining continuous drug presence via sustained delivery may be an improvement over fluctuating drug levels resulting from daily topical therapy."

About Ocular Therapeutix's Travoprost Punctum Plugs:

Ocular Therapeutix's travoprost punctum plugs use the company's proprietary polyethylene glycol hydrogel technology to release travoprost in a sustained fashion over a specified period of time.  At the end of the treatment period, the plug begins to absorb, and exit the nasolacrimal system without need for removal by the physician. The plugs contains a visualization agent for retention monitoring throughout the treatment period. 

About Ocular Therapeutix, Inc.:

Founded in November 2006, Ocular Therapeutix, Inc. is a privately held company based in Bedford, MA, focused on the development and commercialization of ophthalmic therapeutic products using its proprietary hydrogel technology. Ocular Therapeutix is using its hydrogel technology for development of a variety of ophthalmic applications including hydrogel sealants for ocular surface protection, drug-eluting punctal plugs for treatment of various anterior segment diseases, and with therapeutic agents for back-of-the-eye diseases.

1Goldberg I. Compliance with Medical Management in Glaucoma. Asian J of Ophthalmol 2000;2(4):3-6.


'/>"/>
SOURCE Ocular Therapeutix, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Inaugural National Mobility Awareness Month Commences in May Saluting the More than 18 Million with Disabilities
2. Bausch + Lomb Commences Tender Offer of Its 9 7/8% Senior Notes due 2015 (CUSIP Nos. 071707AN3 and U07190AA6)
3. American Pacific Corporation Commences Debt Refinancing
4. Perrigo Receives FDA Approval And Commences Launch Of Clobetasol Propionate Shampoo, 0.05%
5. Bluechiip Receives First Sales Order from ATCC after Completion of Successful Pilot Trial
6. In Pilot Study, a Peptide Controls Blood Sugar in People with Congenital Hyperinsulinism
7. Argos Therapeutics Secures $25 million Series D Financing to Commence Phase 3 ADAPT Study in Patients with Metastatic Renal Cell Carcinoma (mRCC) in Mid-2012
8. Anthera Announces the Completion of Patient Dosing in Phase 2b PEARL-SC Study
9. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
10. Retrospective Study Suggests that Stereotactic Ablative Radiotherapy (SABR) Can be a Viable Option for Treating Early-Stage Lung Cancer in Operable as well as Inoperable Patients; Phase III Randomized Trial Now Under Way
11. Ultragenyx Announces Phase 1 Results of UX001 in Hereditary Inclusion Body Myopathy (HIBM), a Rare Neuromuscular Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... Francisco, CA (PRWEB) , ... October 12, 2017 ... ... Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent ... apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical ... Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. ... honor of Morris F. Collen, a pioneer in the field of medical informatics, this ...
(Date:10/12/2017)... Malvern, PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best ... New York City on October 11, 2017. , The annual award competition recognizes editorial ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... (HLA), the nation's first interactive health literacy software tool, and the Cancer Patient ... aspects of cancer patient education, today announce a new strategic alliance. , ...
Breaking Medicine News(10 mins):