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Octapharma Targets Primary Immune Deficiency Research With Grant for The Mount Sinai Medical Center
Date:1/18/2011

bers.html">Flemming Nielsen. "Dr. Cunningham-Rundles is a well-recognized national leader in the field of clinical and laboratory immunology and we consider her research extremely important in understanding how to best diagnose and treat primary immune deficiency earlier and more effectively. The grant program and its second award will continue to advance Octapharma's firm commitment to the U.S. market, underscoring our commitment to provide patients with the safest, highest quality therapies available today."

CVID is a primary immune defect characterized by poor or absent production of immune globulins IgG, IgA and/or IgM. CVID is a type of primary immune deficiency disease with high clinical interest due to its prevalence, severity of complications, rate of hospitalizations and necessity for lifelong immune globulin therapy.  Unfortunately, using the available published criteria for diagnosing CVID, physicians have difficulty distinguishing this disease from milder immune defects of antibody production.  The difficulty of distinguishing between patient groups is medically important as subjects with validated CVID appear more likely to develop selected inflammatory complications which may require additional monitoring or treatment. Patients with more modest defects may be more exempt from these issues and could require different clinical surveillance.

"The aim of our research is to provide the medical community and patients with information and tools to distinguish the more clear cases of CVID from other milder antibody disorders," said Dr. Cunningham-Rundles. "By reviewing and analyzing clinical records and available laboratory data, we will work toward the development of a scoring system as a clinical tool.  With the large cohort of patients seen at The Mount Sinai Medical Center, the study may be able to determine if the immunologic and clinical differences seen in various defects can be distinguished."

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