Navigation Links
Obesity-Related Hormone is Higher in Children with Down Syndrome
Date:10/26/2007

PHILADELPHIA, Oct. 26 /PRNewswire-USNewswire/ -- Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers. The hormone, leptin, may contribute to the known higher risk of obesity among children and adults with Down syndrome.

A research team from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine published their study online today in the Journal of Pediatrics.

The researchers studied 35 children with Down syndrome and 33 of their siblings. All of the children were between the ages of four and 10, and were from the Philadelphia area. The researchers intentionally did not include severely obese children in the study, in order to focus on risk factors for obesity before obesity occurred.

The children with Down syndrome had significantly higher body mass index, a higher percentage of body fat, and higher levels of leptin compared to their siblings. The higher leptin levels persisted even when the researchers adjusted for the effect of percentages of body fat, suggesting that differences in body composition did not account for the difference in leptin levels.

"The normal role of leptin is to suppress appetite and regulate body weight," said senior author Nicolas Stettler, M.D., MSCE, a pediatric nutrition specialist at The Children's Hospital of Philadelphia. "In general, obese people have higher levels of leptin, which suggests that they have some leptin resistance--their bodies do not respond to the hormone properly. Because Down syndrome is a chromosome disorder, children with Down syndrome may have a genetic predisposition to more severe leptin resistance."

Sheela N. Magge, M.D., M.S.C.E., a pediatric endocrinologist at Children's Hospital, the first author of the study, stressed that more research remains to be done on this question, as the reasons are yet uncertain why pa
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Arterial Plaque Significantly Reduced in Women Age 50-59 Taking Hormones, Says New Analysis of Womens Health Initiative Data
2. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
3. Updated Study Results Reinforce Survival Benefit of Taxotere (Docetaxel) for Men with Advanced, Hormone-Resistant Prostate Cancer
4. Doctors Outraged Over Growth Hormone Controversy
5. Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies
6. New Analysis of Data from WHI Provides Reassurance With Respect to Coronary Heart Disease For Newly Menopausal Women Considering Hormone Therapy
7. Data on Higher Dose of Copaxone and Data Showing Copaxone is Most Cost Effective
8. Data Published in Neurology Showed That Higher Dose of Copaxone Increased Efficacy in Relapsing-Remitting Multiple Sclerosis (RRMS)
9. New Clinical Study Results Indicate Higher Early Virologic Response with Celgosivir Combination Therapy in HCV Non-Responders
10. Diabetes Linked to Higher Parkinsons Risk
11. Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... , May 27, 2015 ... announced the addition of the  "2015 Strategies ...  report to their offering.  ... five-country report contains 500 pages, 120 tables, ... and potential market entrants identify and evaluate ...
(Date:5/27/2015)... , May 27, 2015 OpportunityAnalyzer: Cushing,s ... Summary GlobalData estimates that the 2013 ... was approximately $179m across the 6MM covered in ... investing their attention, time, and financial resources in ... research and development (R&D) strategies. One notable example ...
(Date:5/27/2015)... YORK , May 27, 2015 PharmaPoint: ... Forecast and Market Analysis to 2022 - Event-Driven Update ... dominated by generics and GlaxoSmithKline,s Benlysta is the only ... more than 50 years. Following Benlysta,s launch, patients, uptake ... price-tag Benlysta has managed to grow the lupus market ...
Breaking Medicine Technology:European Hemostasis Diagnostic Testing Market Strategies 2015 2OpportunityAnalyzer: Cushing's Syndrome - Opportunity Analysis and Forecasts to 2018 2OpportunityAnalyzer: Cushing's Syndrome - Opportunity Analysis and Forecasts to 2018 3OpportunityAnalyzer: Cushing's Syndrome - Opportunity Analysis and Forecasts to 2018 4PharmaPoint: Systemic Lupus Erythematosus and Lupus Nephritis - Global Drug Forecast and Market Analysis to 2022 - Event-Driven Update 2PharmaPoint: Systemic Lupus Erythematosus and Lupus Nephritis - Global Drug Forecast and Market Analysis to 2022 - Event-Driven Update 3
... Seidman Cancer Center at University Hospitals (UH) Case Medical Center ... research findings in 25 presentations this weekend at the 53rd ... the San Diego Convention Center. "The breadth and ... truly outstanding," says Stan Gerson, MD, Director of ...
... major research advances over the last several decades that ... condition remains deadly. Specialists are in need of new ... therapies that will extend patients, lives. New research addressing ... will be presented today at the 53rd Annual Meeting ...
Cached Medicine Technology:UH Seidman Cancer Center Researchers Present Findings at American Society of Hematology Annual Meeting 2UH Seidman Cancer Center Researchers Present Findings at American Society of Hematology Annual Meeting 3UH Seidman Cancer Center Researchers Present Findings at American Society of Hematology Annual Meeting 4UH Seidman Cancer Center Researchers Present Findings at American Society of Hematology Annual Meeting 5Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 2Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 3Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 4Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 5Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 6Genetic and Proteomic Advances Pave the Way for Next-Generation Leukemia Therapies 7
(Date:5/27/2015)... Dr. Omar Ibrahimi, Dermatologist and Director ... has been selected as part of a controlled launch ... the only physician in Connecticut) to offer the new ... removal of submental fat (double chin). The procedure is ... surgery and minimal risks. Dr. Ibrahimi is an invited ...
(Date:5/27/2015)... Black Book Rankings, well known internationally ... multiple services and software industries, conducted a sweeping ... Electronic Health and Medical Record software systems for ... on implemented EHR users, Black Book reveals industry ... highest scores in client experience among small and ...
(Date:5/27/2015)... 2015 The Case Management Society ... to provide CMSA's Career and Knowledge Pathways educational ... to strengthen the case/care management workforce by offering ... The mutually beneficial agreement provides Medix, a workforce ... talent in the healthcare, scientific and IT industries, ...
(Date:5/27/2015)... 27, 2015 Difass USA, a modern ... U.S. with its first three flagship products, Dormiva™, Relaxiva™ ... nationwide through http://www.difassusa.com . , A restful ... productivity, but some people struggle with getting the full ... a sleep aid designed to help you fall asleep ...
(Date:5/27/2015)... On June 5, Plan B [the ... with LifeSource to host Donate Your Break, a public ... a LifeSource donor coach outside of 116 W. Illinois ... Demand for whole blood units is highest for LifeSource, ... months. LifeSource requires approximately 1,000 donations per day to ...
Breaking Medicine News(10 mins):Health News:Connecticut Skin Institute First in Connecticut to Offer New Surgery-Free “Double Chin” Fat Reduction Treatment 2Health News:Connecticut Skin Institute First in Connecticut to Offer New Surgery-Free “Double Chin” Fat Reduction Treatment 3Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 2Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 3Health News:Cloud-Based Electronic Health Record firms sweep top physician satisfaction rankings for Small and Solo Practices, reveals 2015 Black Book survey 4Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 3Health News:Supplement Brand Difass USA Launches in the U.S. with Three Flagship Products Designed to Bring Balance Back to Your Life 2Health News:Donate Your Break and Save Lives at the River North Blood Drive 2
... Children dependent on electrically powered medical devices for life ... of power and their parents are ill-prepared to ... Oct. 16, at the American Academy of Pediatrics (AAP) ... special health care needs are medically complex and often ...
... 15 (HealthDay News) -- Head injuries are a major cause ... finds. Researchers examined data on 52 children younger than ... trauma center between 2003 and 2011. The 34 boys and ... most common cause of injury was hitting a tree (63.5 ...
... percent of children hospitalized following a sledding injury suffered ... had a permanent disability. The research, presented Saturday, Oct. ... Conference and Exhibition (NCE) in Boston, supports the need ... traumatic sledding injuries. Researchers reviewed data on children ...
... , FRIDAY, Oct. 14 (HealthDay News) -- ... don,t see the immediate consequences of their actions and ... be traced back to them, according to one expert. ... online, she doesn,t have to witness the target,s hurt ...
... Mich. It,s difficult for doctors to tell whether ... requires surgery, or inflammation, which can be treated with ... easier, according to a U-M-led study. Ultrasound elasticity ... the distinction between inflammation and fibrosis, allowing patients to ...
... women who experience new onset breast tenderness after starting ... breast cancer compared to women who don,t experience breast ... Cancer Center has shown. One reason for this may ... The new onset tenderness was much more pronounced after ...
Cached Medicine News:Health News:Children dependent on life support vulnerable to loss of electrical power 2Health News:Helping Teens Fend Off Attacks by Cyberbullies 2Health News:Imaging technology might help doctors determine best treatment for Crohn's disease patients 2Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 2Health News:Breast tenderness in women getting combo hormone therapy associated with increase in breast density 3
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
... Capture Archive Manage ... Images. ,Introducing Optronics DVMR- office, ... system designed for the physician's ... from a variety of high-resolution ...
... Optronics QuantiFIRE represents the latest innovation ... scientific grade CCD imaging for microscopy. ... Monochrome CCD camera developed exclusively for ... fluoresence or NIR imaging applications where ...
... This system is the most ... world. Developed in the USA after ... safety, and complete precision with maximum ... exfoliation. It is superior to traditional ...
Medicine Products: