Navigation Links
Obesity-Related Hormone is Higher in Children with Down Syndrome
Date:10/26/2007

PHILADELPHIA, Oct. 26 /PRNewswire-USNewswire/ -- Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers. The hormone, leptin, may contribute to the known higher risk of obesity among children and adults with Down syndrome.

A research team from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine published their study online today in the Journal of Pediatrics.

The researchers studied 35 children with Down syndrome and 33 of their siblings. All of the children were between the ages of four and 10, and were from the Philadelphia area. The researchers intentionally did not include severely obese children in the study, in order to focus on risk factors for obesity before obesity occurred.

The children with Down syndrome had significantly higher body mass index, a higher percentage of body fat, and higher levels of leptin compared to their siblings. The higher leptin levels persisted even when the researchers adjusted for the effect of percentages of body fat, suggesting that differences in body composition did not account for the difference in leptin levels.

"The normal role of leptin is to suppress appetite and regulate body weight," said senior author Nicolas Stettler, M.D., MSCE, a pediatric nutrition specialist at The Children's Hospital of Philadelphia. "In general, obese people have higher levels of leptin, which suggests that they have some leptin resistance--their bodies do not respond to the hormone properly. Because Down syndrome is a chromosome disorder, children with Down syndrome may have a genetic predisposition to more severe leptin resistance."

Sheela N. Magge, M.D., M.S.C.E., a pediatric endocrinologist at Children's Hospital, the first author of the study, stressed that more research remains to be done on this question, as the reasons are yet uncertain why pa
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Arterial Plaque Significantly Reduced in Women Age 50-59 Taking Hormones, Says New Analysis of Womens Health Initiative Data
2. Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin
3. Updated Study Results Reinforce Survival Benefit of Taxotere (Docetaxel) for Men with Advanced, Hormone-Resistant Prostate Cancer
4. Doctors Outraged Over Growth Hormone Controversy
5. Data Presented at AACR Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Growth of Both Hormone-Dependent and Hormone-Independent Prostate Cancer by Up to 94 Percent in Preclinical Studies
6. New Analysis of Data from WHI Provides Reassurance With Respect to Coronary Heart Disease For Newly Menopausal Women Considering Hormone Therapy
7. Data on Higher Dose of Copaxone and Data Showing Copaxone is Most Cost Effective
8. Data Published in Neurology Showed That Higher Dose of Copaxone Increased Efficacy in Relapsing-Remitting Multiple Sclerosis (RRMS)
9. New Clinical Study Results Indicate Higher Early Virologic Response with Celgosivir Combination Therapy in HCV Non-Responders
10. Diabetes Linked to Higher Parkinsons Risk
11. Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)...   Royal Philips (NYSE: ... and eCareCompanion telehealth applications have received 510(k) clearance ... A part of Philips Hospital to Home,s ... are focused on patient care within the home ... available through the cloud-based digital health platform, which ...
(Date:10/1/2014)... LAUSANNE , Suisse, October 1, 2014 /PRNewswire/ ... génomique clinique et dans le domaine de l,analyse ... a lancé aujourd,hui une solution de diagnostic in ... d,exécuter une analyse complète de la mucoviscidose dans ... d,identifier et de caractériser tous les types de ...
(Date:9/30/2014)... 30, 2014  Wrightington, Wigan ... MDRX ) are delighted to announce WWL,s ... new health information system. The system will be implemented ... the way WWL delivers healthcare in the future. ... record of on-time and on-budget system implementations as well ...
Breaking Medicine Technology:Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 2Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 3Philips Secures 510(k) Clearance to Market the First Clinical Applications for its new Digital Health Platform 4Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 2Sophia Genetics lance une analyse complète du gène CFTR dans un essai clinique SGN 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 2Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 4
... , July 28 HemaQuest Pharmaceuticals, a ... sickle cell disease, beta thalassemia and EBV-related cancers, announced ... to its Series B financing by new investor, Latterell ... financing to $16M . The financing is intended ...
... July 27 /PRNewswire-Asia/ -- WuXi PharmaTech (Cayman) Inc. ... Proxy Advisory Services,("ISS"), a leading independent proxy voting and corporate ... River,s proposed,acquisition of WuXi. Two other proxy advisory services, Glass ... the,transaction. , , ...
Cached Medicine Technology:HemaQuest Pharmaceuticals Raises Additional $4M to Bring Total to $16M in Series B Financing 2ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 2ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 3ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 4ISS Recommends That WuXi Shareholders Vote for Proposed Combination With Charles River 5
(Date:10/1/2014)... Lifeinsurance-policy.com has released a new blog post explaining how ... , Smoking will always have a negative impact on ... method to find affordable coverage. Insurance brokerage websites specialize ... , Whole life insurance premiums will be fixed throughout ... is permanent, the initial rates are very important. ...
(Date:10/1/2014)... ST. LOUIS, MO (PRWEB) October 01, 2014 ... up for Castlewood Eating Disorder Treatment Center’s first ever charity ... provides grants for people with eating disorders who cannot afford ... Fox Run Golf Club in Eureka, Mo. , The ... time at noon. A reception and award dinner will begin ...
(Date:10/1/2014)... Diet Doc understands that many of their clients ... their dieting attempts could be easily sabotaged by the temptation ... treatments into their programs as a way to control ... effective weight loss results, it also allows patients to stick ... their weight for the future. , Earlier versions of the ...
(Date:10/1/2014)... the occasion of the Leishmaniasis East Africa Platform ... international leishmaniasis experts, results of a pharmacovigilance ... plan, carried out by MSF, DNDi, and national ... presented to key decision makers in order to ... the combination of Sodium Stibogluconate and Paromomycin (SSG&PM) ...
(Date:10/1/2014)... Today marks the final day prosthodontist Dr. Saj ... and Woodland Hills, Calif., is in the southern India ... “Speaking to this group of specialists allows more people ... help and care they deserve,” Dr. Jivraj said. , ... providing cosmetic dentistry, correcting bite issues, placing implants, and ...
Breaking Medicine News(10 mins):Health News:Affordable Whole Life Insurance Premiums for Smokers! 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 2Health News:Project HEAL Benefit Golf Tournament Gaining Momentum 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 2Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 3Health News:Diet Doc Announces Their New Version of the Hormone Diet Plan to Target, Attack and Burn Fat Without Dangerous Side Effects 4Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... 27 New Jersey Senate Majority Leader Stephen M. Sweeney ... join Labor Leaders Charles Wowkanech , President of the New ... Counties Central Labor Council and Henry Nichola s, President of ... rallies in Deptford and Hammonton, N. J., in support of ...
... Governor Edward G. Rendell today announced that ... Senate confirmation:State Board of Medicine , James W. ... of Nursing Home Administrators , Mary Ann Hewston, ... creating a first-rate public education system, protecting our ...
... Healthier, More Productive PracticeNEWBERG, Ore., Feb. 27 ... is well-positioned to fit small spaces and conservative ... a mid-level platform choice that,s lower in cost ... performance, service, and support that distinguish A-dec products. ...
... can be used on all women with diagnosis, study ... new genetic test that analyzes a set of 50 ... lead to quicker, more immediate treatment for patients, according ... "Unlike a widely used genomic test that applies only ...
... Refute USA Today ReportHARRISBURG, Pa., Feb. 27 The ... unsafe levels of air pollutants or metals after extensively ... schools.Environmental Protection acting Secretary John Hanger said that the ... USA Today in December 2008 that relied only ...
... Feb. 27 Smith & Nephew, Inc.,(NYSE: ... announced the,introduction of a metal liner option for its ... in hip replacement and resurfacing,procedures. , ... Food and Drug Administration,for use with the BIRMINGHAM HIP(TM) ...
Cached Medicine News:Health News:Politicians and Labor Leaders Set to Lead Rallies Saturday (February 28) for Striking Innova Nurses 2Health News:New A-dec 300(TM) Offers Dentists an Innovative Equipment Solution 2Health News:New Test May Mean Faster Breast Cancer Treatment 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 3Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 2Health News:Smith & Nephew Introduces Metal Liner Option for the Modular R3(TM) Acetabular Cup System 3
... secreted by the kidney, plays a ... The renin-angiotensin system regulates blood pressure, ... by the kidney. Renin is secreted ... decreased intravascular volume and decreased plasma ...
... polypeptide hormones which belong to the ... TGF- superfamily is a large group ... many aspects of development, reproductive function ... incude TGF-s, bone morphogenetic proteins, growth ...
... hormones which belong to the transforming ... superfamily is a large group of ... aspects of development, reproductive function and ... TGF-s, bone morphogenetic proteins, growth differentiation ...
... also known as bone Gla protein, is ... is a major component of the noncollagenous ... osteoblasts in bone, with a small amount ... chondrocytes [1]. During bone formation, newly synthesized ...
Medicine Products: