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ObeTherapy Announces the Publication of Results Obtained with one of its Lead Compounds on a New Target for the Treatment of Obesity and Type II Diabetes
Date:12/4/2012

sure of eating while losing weight, greatly facilitating the changes in personal habits that may be required for a long-term solution to their condition.

The CEO and founder of the Company, Dr. Itzik Harosh, explained that enteropeptidase is a peripheral enzyme localized on the epithelial surface of the duodenum. This constitutes a major advantage over a systemic target, in that an inhibitor needs not be absorbed to express its activity, minimizing the probability of toxicity and side effects. This new approach of identification new targets based on «lean or starvation phenotype» should open new avenues in obesity and diabetes drug discovery.

A novel, orally administered enteropeptidase inhibitor shows very promising results in vivo. This compound is a pseudopeptide with negligible bioavailability.  Furthermore, if injected directly in the bloodstream, it is destroyed and cleared within minutes.  Few, if any, side effects are thus anticipated.

Professor Marco A. Ciufolini, of the University of British Columbia at Vancouver, and a consultant in synthetic chemistry for Obetherapy, indicated that the inhibitor in question can be manufactured on large scale after only minor modifications of the current route. 

Dr. Harosh declared that these results should promote the development of the company and assist ObeTherapy in establishing new collaborations and fund raising.

Obetherapy Biotechnology is a company specializing in the research and development of new drugs for the treatment of obesity, hypercholesterolemia, and type II diabetes. It is localized on the Génopôle® campus, in Evry, France.  Unlike its competitors, who concentrate on the genetic characterization of obesity, ObeTherapy follows an innovative approach that centers on the analysis of individuals with a "lean" phenotype. The Company is especially interested in the study of patients suffering from rare monogenic diseases character
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SOURCE ObeTherapy Biotechnology
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