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ObeTherapy Announces the Publication of Results Obtained with one of its Lead Compounds on a New Target for the Treatment of Obesity and Type II Diabetes
Date:12/4/2012

PARIS, December 4, 2012 /PRNewswire/ --

ObeTherapy, a company focusing on the treatment of obesity and type II diabetes,  announces the publication of results that validate a new therapeutic target associated with  "starvation" human phenotype and a novel small-molecule candidate for the treatment of obesity and type II diabetes,

The article, entitled: Enteropeptidase: a gene associated with a starvation human phenotype and a novel target for obesity treatment, http://dx.plos.org/10.1371/journal.pone.0049612, Numerous genes associated with obesity have been targeted over the years to treat such a condition. However, none of these has provided an effective treatment for either obesity or type II diabetes.  Many commercial drugs that target such genes have been withdrawn from the market on accounts of lack of efficacy, lack of specificity, and/or toxicity. It is therefore essential to identify new gene targets that are specific, non-redundant and associated to lean phenotype.  

Research at ObeTherapy aims to identify genes that are implicated in a "lean" human phenotype by addressing the following questions:  Are there any genetic diseases that produce a "lean phenotype"? If so, is such a condition dependent upon a single gene (i.e., is it a monogenic disease)? Is such a gene tissue-specific? Is it redundant?

Congenital enteropeptidase deficiency is an extremely rare pathology that satisfies the foregoing criteria.  Patients suffering from such a condition can eat ad libitum without gaining weight; indeed, if left untreated, they will lose weight and ultimately starve (starvation phenotype).  Thus, partial inhibition of enteropeptidase with an approriate drug should allow obese patients to nourish themselves normally, yet assimilate only a fraction of the total energy consumed during a meal. These patients would thus retain the plea
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SOURCE ObeTherapy Biotechnology
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