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OVA1 Improves Ovarian Cancer Detection Over CA 125 Blood Test and Clinical Assessment
Date:5/24/2011

o an adequate job of identifying early stage ovarian cancer," states Dr. Frederick Ueland, author of the paper and principal investigator of the OVA1 clinical trial. "In this study, OVA1 identified 98% of early stage epithelial ovarian cancers compared to 68% identified by CA 125. Furthermore, OVA1 identified 93% of premenopausal early stage cancers compared to only 36% identified by CA 125."

The OVA1 test incorrectly identified non-cancerous masses about twice as often as CA 125 or clinical assessment. A higher false positive rate may increase patient distress and the number of surgeries that specialists unnecessarily perform. Dr. Ueland noted in the study that in current clinical practice only 12% to 40% of patients referred to gynecologic oncologists have malignant disease, and therefore the OVA1 false positive rate is in line with real-world referral patterns.

Of more importance is the decreased number of false negatives or undetected cancers when OVA1 is added to a physician's assessment, which is reduced from 28% to 8% in non-gynecologic oncologist assessment and from 21% to 1% in gynecologic oncologist assessment. This translates into potentially more cancers being referred to a gynecologic oncologist for initial surgery. The investigators go on to say, "hopefully, earlier referral of patients with ovarian cancer will improve survival and reduce the number of required re-operation."

The study manuscript follows online publication on May 9, 2011 in Obstetrics & Gynecology that suggested OVA1 may be appropriate in place of CA 125 in ACOG referral guidelines for women under evaluation for an ovarian mass ("Performance of the American College of Obstetricians and Gynecologists' Ovarian Tumor Referral Guidelines With a Multivariate Index Assay," by Dr. Rachel Miller.) The two articles are based on data from the same study and both are published in the June 2011 print edition.

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SOURCE Quest Diagnostics
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