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OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye Infection
Date:2/25/2008

es. The authors concluded that NCT might be useful as a topical drug for the treatment of AK infections.

NCT is a derivative of a naturally occurring substance in the body with broad anti-microbial properties. OPKO has in-licensed exclusive worldwide development and commercialization rights to a proprietary formulation of NCT for ocular uses from Pathogenics, Inc. OPKO is currently developing NCT for the treatment of viral conjunctivitis, while Pathogenics is assessing NCT in Phase II studies for topical and body cavity infections.

"These encouraging new data provide further evidence of the safety and anti-microbial efficacy of ACU-NCT-001, OPKO's formulation of N-Chlorotaurine," said Samuel Reich, Executive Vice President of OPKO Ophthalmics. "If the broad spectrum activity of NCT continues to be confirmed in clinical trials, its combination of tolerability and anti-infective efficacy could make it a potentially valuable new agent for addressing a variety of ocular infections."

NCT has been shown to have promising anti-microbial activity against bacteria, yeasts and molds, as well as antiviral activity against a number of viruses. To date, NCT has been shown to be safe and well tolerated in multiple applications, including sinus and ear infections, as well as in viral conjunctivitis, or pink eye. Its natural sterility and absence of preservatives make NCT especially well-suited for ocular applications.

About Acanthamoeba keratitis (AK)

Acanthamoeba keratitis is an infection of the transparent outer covering of the eye, or the cornea, caused by a microscopic, free-living amoeba. Acanthamoeba is commonly found in water, soil and air. AK infection is uncommon in healthy individuals, but contact lens wearers who improperly store or disinfect their lenses or who wear lenses while showering or swimming are at higher risk of developing an infection. Current treatment regimens can last a year or more and include a combination of prescript
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SOURCE OPKO Health, Inc.
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