OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye... ( -In Vitro Data Shows OPKO's Formul...)

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OPKO Health and Pathogenics Announce Data Publication Demonstrating the Potential Utility of NCT in a Severe Eye Infection

Date:2/25/2008

-In Vitro Data Shows OPKO's Formulation of NCT Has Promising Activity

Against Acanthamoeba Keratitis, a Serious Ocular Infection-

-Provides Additional Evidence That This Phase II Agent Has Good Tolerability and Broad Anti-Microbial Activity Against a Wide Range of

Pathogens-

MIAMI and HINGHAM, Mass., Feb. 25 /PRNewswire-FirstCall/ -- OPKO Health, Inc. (Amex: OPK) and Pathogenics, Inc. (PTGN.PK) today announced the publication of preclinical data demonstrating the potential therapeutic utility of their proprietary formulation of N-Chlorotaurine (NCT) in the treatment of Acanthamoeba keratitis (AK), a serious eye infection that can result in vision impairment or blindness. AK, which in its ocular form most commonly infects contact lens wearers, is caused by a microscopic amoeba parasite that is present in water, soil and air. Current treatments for ocular AK are potentially toxic and difficult-to-handle. The study was published in the current edition of Antimicrobial Agents and Chemotherapy.*

Led by Dr. Ursula Furnkranz of the Clinical Institute of Hygiene and Medical Microbiology, Medical University of Vienna, Austria, the study authors assessed NCT's microbicidal effect on different strains of the parasite Acanthamoeba, including both the free-living and difficult-to-treat cystic form. The authors showed that, in vitro, NCT clearly demonstrated amoebicidal activity at concentrations that are likely to be well tolerated in humans. They also reported that co-treatment with ammonium chloride appeared to further enhance NCT's anti-parasitic activity, including its activity against Acanthamoeba cysts, resulting in the complete loss of viability of the infection-causing parasit
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