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NxStage(R) Reports Third Quarter 2009 Financial Results and Raises Revenue Guidance for Fiscal 2009

generally accepted accounting principles in the United States and may be different from similar non-GAAP financial measures used by other companies. The non-GAAP financial measure disclosed by the Company is not meant to be considered superior to, or a substitute for, results of operations prepared in accordance with GAAP. Management uses Adjusted EBITDA (EBITDA adjusted for stock based-compensation, deferred revenue recognized, and other non-recurring expenses) to understand operational cash usage. The Company believes the non-GAAP financial measure provides useful and supplementary information allowing investors greater transparency to one measure used by management. The non-GAAP financial measure is meant to supplement, and to be viewed in conjunction with, GAAP financial measures. The non-GAAP financial measure is reconciled to the most comparable GAAP financial measure below.

                            NxStage Medical, Inc.
               Condensed Consolidated Statements of Operations
                    (in thousands, except per share data)

                                  Three Months Ended   Nine Months Ended
                                     September 30,       September 30,
                                     -------------       -------------
                                      2009      2008      2009      2008
                                      ----      ----      ----      ----

    Revenues                       $38,033   $30,466  $108,166   $93,087
    Cost of revenues                28,488    25,684    82,749    79,872
                                    ------    ------    ------    ------
        Gross profit                 9,545     4,782    25,417    13,215
                                     -----     -----    ------    ------

    Operating expenses:
      Selling and marketing          7,449     6,839    22,091    20,937
      Research and development       2,707     1,98
SOURCE NxStage Medical, Inc.
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