Navigation Links
Nventa Enrolls and Initiates Dosing of Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial
Date:3/11/2008

SAN DIEGO, March 11 /PRNewswire-FirstCall/ -- Nventa Biopharmaceuticals Corporation (TSX: NVN) today announced that the Company has completed enrollment and initiated dosing of the fourth and final cohort of patients in its Phase 1 dose escalation trial. This study examines the safety of its lead candidate, new HspE7 (HspE7 + Poly-ICLC, a toll-like receptor-3, or TLR3 agonist), in patients with cervical intraepithelial neoplasia, or CIN, a precursor to cervical cancer. New HspE7 is an investigational therapeutic vaccine targeting human papillomavirus (HPV)-related diseases.

(Logo: http://www.newscom.com/cgi-bin/prnh/20080303/LAM023LOGO)

"Conclusion of enrollment in this study is a significant milestone for Nventa," said Gregory M. McKee, President and Chief Executive Officer at Nventa. "We have spent considerable time analyzing the need for a fifth cohort in this study, and have determined that the fourth cohort dose level is likely optimal for future clinical trials. Following completion of this Phase 1 study, we anticipate launching a comprehensive Phase 2 program studying the safety and efficacy of new HspE7 in patients with CIN."

When complete, the Phase 1 trial will have dosed four cohorts totaling seventeen patients with a fixed dose of 500 mcg of HspE7 and either 50, 500, 1,000 or 2,000 mcg of the adjuvant, Poly-ICLC. In addition to safety data, immunological data are being collected pre-treatment, following each dose of new HspE7, and at the end of the study from all patients, which could provide an early indication of potential activity of new HspE7. All patients are also being typed for class I and II human leukocyte antigen (HLA) subtypes, and are being evaluated for cytokine responses, anti-HspE7 antibodies and cellular (T-cell) immunology.

Affiliations and investigators in this trial currently have included the Montefiore Medical Center
'/>"/>

SOURCE Nventa Biopharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial
2. VIA Pharmaceuticals Enrolls First Patient in Phase 2 Clinical Trial to Measure Impact of VIA-2291 to Reduce Vascular Inflammation
3. Spectranetics Enrolls First Patient in PATENT Trial for the Treatment of Instent Restenosis
4. Ception Therapeutics Initiates Phase II/III Clinical Trial for Its Lead Product Reslizumab in Eosinophilic Esophagitis (EE) in Children
5. Pharmacopeia Initiates Second Phase 2 Hypertension Study with PS433540 (DARA)
6. Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid
7. Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status
8. Tigris Pharmaceuticals Initiates Phase I Study of AFP-464 in Patients with Solid Tumors
9. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
10. Northwestern Memorial Transplant Program Initiates New Study
11. Cerimon Pharmaceuticals Initiates Phase II/III Clinical Studies to Evaluate its Diclofenac Patch for Mild to Moderate Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... YORK, Pa. , Sept. 2, 2015 ... and ASX: UNS), a developer, manufacturer and supplier ... response to third-party initiated expressions of interest, the Company,s ... LLC to conduct a review of strategic alternatives to ... to be explored and evaluated during the review process ...
(Date:9/2/2015)... , Sept. 2, 2015  Aethlon Medical, Inc. (Nasdaq: ... and CEO, will be presenting at the Rodman & Renshaw ... NY at 9:35 a.m. ET on Thursday, September ... to the public via live audio webcast which can be ... corporate website at http://www.aethlonmedical.com . The webcast will be ...
(Date:9/2/2015)... -- Simplified Genetics , the only provider of consumer ... in the U.S., announced today the launch of two groundbreaking ... health found within specific genes – all with a simple ... The tests include Simply Fit and Simply ... that maps four key genes to provide individuals with the ...
Breaking Medicine Technology:Unilife Announces Review of Strategic Alternatives 2Simplified Genetics Decodes DNA's Blueprint for Individual Health and Safety 2Simplified Genetics Decodes DNA's Blueprint for Individual Health and Safety 3
... Memorial Hospital one of 18 centers involved in 10-year ... 10-year study,published in the August 28 issue of the ... to women delivering before 32,weeks of gestation reduced the ... of Antenatal Magnesium Sulfate (BEAM) trial was,conducted in 18 ...
... Recognized Pediatric Heart Center at The Children,s Hospital at, ... ... Specialty Services, Newly Recruited Pediatric ... The Children,s Hospital at,Montefiore (CHAM) is bringing the medical miracle ...
Cached Medicine Technology:National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births 2National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births 3Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 2Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 3Pediatric Heart Transplants at Montefiore Approved by NY State Department of Health 4
(Date:9/2/2015)... Las Vegas, NV (PRWEB) , ... September 02, ... ... Las Vegas and Fort Lauderdale, CENTURION SERVICE GROUP is internationally known as an ... largest medical auction house in the world, selling more than 100,000 pieces of ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... helping to bring awareness to International Overdose Awareness Day. The goal is to ... recognize the warning signs so that they may get help. , ...
(Date:9/2/2015)... ... 2015 , ... Please join the world renowned Brain Aneurysm ... established by the Foundation in 2007 with the help of Massachusetts State Representative ... remains our top priority,” commented Christine Buckley, Executive Director of the Brain Aneurysm ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... of Breast Cancer Awareness Month (BCAM), Bright Pink, a national non-profit focused on ... will launch Act On Facts, a campaign to educate women to be breast ...
(Date:9/1/2015)... ... September 01, 2015 , ... An August 25 ... of plastic surgeries conducted each year on teenagers, quoting a New York City-area ... Beverly Hills-based plastic surgeon Payam Jarrah-Nejad, M.D., F.I.C.S., F.A.C.S., known more familiarly to ...
Breaking Medicine News(10 mins):Health News:Over 1800 Lots of Surplus Used Medical Equipment 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 3Health News:August 31 is International Overdose Awareness Day – Lakeview Health to Help Bring Awareness 2Health News:September Celebrated as Brain Aneurysm Awareness Month 2Health News:Bright Pink Launches Act On Facts™, A Campaign To Empower Young Women To Take Action Related To Their Breast And Ovarian Health 2Health News:Bright Pink Launches Act On Facts™, A Campaign To Empower Young Women To Take Action Related To Their Breast And Ovarian Health 3Health News:Teen Plastic Surgery Article Understates the Most Important Realities of Procedures on Young People, Notes Dr. J 2
... January 12, 2010 (BRONX, NY) Older women ... lesions that cause dementia later in life, according to ... The findings were published in the December 2009 online ... The research was conducted as part of the ...
... WINSTON-SALEM, N.C. A fast-acting compound that appears to ... found in patients with progressive Alzheimer,s disease has been ... Medicine and the Vanderbilt University Medical Center Program in ... result in humans. The compound benzylquinolone carboxylic ...
... ... Molecular Medicine. Molecular Medicine publishes research concerned with the pathogenesis of disease at the ... prevention. , ... January 12, 2010 -- By the time a person experiences symptoms of an aggressive ...
... , DETROIT , Jan. 12 ... Board of Directors has set the date for the Company,s Annual Meeting ... vote at the meeting.   , The Annual Shareholders, Meeting will be ... EST at the MGM Grand Hotel, 1777 Third Street in ...
... hospice and preferred place of death are often needed, experts ... patients have much to consider, from whether they want to ... want doctors to continue aggressive treatment or focus on making ... those difficult, emotional conversations aren,t happening nearly as often, or ...
... WASHINGTON , Jan. 12 The American Lung ... report, which grades the strength of federal and state ... at the heart of America,s chronic disease crisis. , The ... still has significant room for progress. Most state governments , ...
Cached Medicine News:Health News:Hypertension linked to dementia in older women 2Health News:Hypertension linked to dementia in older women 3Health News:New compound improves cognitive decline, symptoms of Alzheimer's disease in rodents 2Health News:New compound improves cognitive decline, symptoms of Alzheimer's disease in rodents 3Health News:News from the Latest Issue of Molecular Medicine 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 2Health News:United American Healthcare Corporation Announces Meeting Date and Record Date for Annual Meeting of Shareholders 3Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 2Health News:Doctors Put Off End-of-Life Talks With Terminally Ill 3Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 2Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 3Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 4Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 5Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 6Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 7Health News:American Lung Association Report Card: Federal Government Makes Major Strides; Most States Flunk for Neglecting to Prevent Tobacco-Caused Disease 8
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: