Navigation Links
Nventa Announces Additional Positive Immunological Data From HspE7 Phase 1 Cervical Dysplasia Trial
Date:5/12/2008

linical responses in patients with CIN. Accordingly, Nventa believes that HspE7 may successfully induce a targeted immune response to effectively treat CIN.

As previously reported, HspE7 was found to be safe and well tolerated in all four study cohorts, with no serious adverse events being reported.

Cohort 1 was designed to establish a baseline for the study with patients in this group being administered 500 mcg of HspE7 and 50 mcg of Poly-ICLC. Consistent with previous preclinical studies conducted by Nventa, this dose level demonstrated anti-HspE7 antibody responses but limited T-cell responses. In cohort 2, patients were administered 500 mcg of HspE7 and 500 mcg of Poly-ICLC. In this group, 3 out of 4 patients showed anti-HspE7 antibody responses and HPV16 E7-specific T-cell responses. These findings, combined with the cohort 3 data announced today, provide additional evidence of the company's predicted mechanism-of-action of HspE7 as demonstrated by early preclinical models and support the compound's potential to treat HPV-16 induced CIN. HPV-16 is the most common subtype of the HPV virus and is responsible for a significant percentage of cases of CIN.

Nventa is currently working with the U.S. Food and Drug Administration (FDA) to finalize the trial design for the company's Phase 2 clinical study for HspE7, which it expects to initiate in patients with high grade cervical dysplasia (CIN 2/3) in mid-2008. In addition to CIN, Nventa is currently evaluating HspE7 as a potential treatment for a broad range of HPV-related pre-cancerous and cancerous diseases, and has a platform to generate other compounds that may treat a variety of other viral associated diseases.

About Cervical Intraepithelial Neoplasia (CIN):

CIN, also known as cervical dysplasia, is characterized by the presence in the cervix of abnormal cells that precede and can develop into cervical cancer. The primary cause of such abnormalities is infection with certain HPV
'/>"/>

SOURCE Nventa Biopharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial
2. Nventa Enrolls and Initiates Dosing of Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial
3. Nventa Announces Positive Interim Immunological Data From HspE7 Phase 1 Cervical Dysplasia Trial
4. Nventa Completes Safety Evaluation on Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial
5. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
9. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
10. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
11. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... Calif. , June 30, 2015 A new ... California,s exposure to high-priced Hepatitis C ... if only 5 percent of Californians infected with Hepatitis C ... the costly impact of new Hepatitis C treatments on public ... grapple with hefty price tags for drugs like Gilead Sciences, ...
(Date:6/30/2015)... , June 30, 2015 Olympus, a ... solutions for medical and surgical procedures, among other ... replacements for surgical equipment at no additional charge. ... offer this type of guarantee. The service became ... Agreement earlier this year. Olympus, ...
(Date:6/30/2015)... , June 30, 2015  Today, the National ... of the 2015 National Mobility Awareness Month Local Heroes ... Local Hero online entries that received 1.3 million votes. ... Chrysler , Toyota Mobility , and Valley ... BraunAbility and Vantage Mobility International (VMI) ...
Breaking Medicine Technology:New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 2New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 3New Analysis Reveals High-Priced Hepatitis C Drugs Could Have Costly Impact on State 4Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 2Olympus Introduces Industry-First Next-Day Product Replacement Guarantee for Surgical Business 3NMEDA Announces National Contest Winners 2NMEDA Announces National Contest Winners 3
... Reportlinker.com announces that a new market ... Interventional Cardiology Devices - ... Forecasts to 2016 ... Devices - Global Pipeline Analysis, Opportunity Assessment ...
... ... if ... var shortURL = ""; BitlyCB.alertResponse = ... to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
Cached Medicine Technology:Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 2Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 3Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 4Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 5Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 6Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 7Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 8Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 9Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 10Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 11Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 12Reportlinker Adds Interventional Cardiology Devices - Global Pipeline Analysis, Opportunity Assessment and Market Forecasts to 2016 13PharmaPendium(TM) Launches Pharmacokinetics Module 2PharmaPendium(TM) Launches Pharmacokinetics Module 3PharmaPendium(TM) Launches Pharmacokinetics Module 4PharmaPendium(TM) Launches Pharmacokinetics Module 5PharmaPendium(TM) Launches Pharmacokinetics Module 6PharmaPendium(TM) Launches Pharmacokinetics Module 7PharmaPendium(TM) Launches Pharmacokinetics Module 8
(Date:6/30/2015)... ... ... Red Hot & Blue Restaurants, Inc. took home the “Best Burger ... was selected as “Best BBQ” in a Texas-based Living Magazine Reader’s Choice ... Randy McCann said, “Everyone knows Red Hot & Blue serves smokin’ fresh Barbecue (smoked ...
(Date:6/30/2015)... ... 30, 2015 , ... An opinion piece published May 28th ... had over breast implants when reconstructing breasts after a mastectomy. The author asserted ... natural,” have increased sensation, and are less likely than implant reconstructions to interfere ...
(Date:6/30/2015)... ... June 30, 2015 , ... New Energy Works Timberframers invites ... and 11th 2015. Timber frame post and beam raisings offer a chance to witness ... timber frame is an important and exciting event – it is an ...
(Date:6/30/2015)... ... June 30, 2015 , ... Board ... ENT and Allergy Center . , Dr. Antunes is a ... sinus and ear procedures. In addition to performing cosmetic and reconstructive surgery on ...
(Date:6/30/2015)... Tennessee (PRWEB) , ... June ... ... of CorrectChemo®, the drug response profiling test to help oncologists provide personalized ... , “The CorrectChemo® assay provides the oncologist with valuable insight on ...
Breaking Medicine News(10 mins):Health News:Red Hot & Blue BBQ Restaurants Voted "Best Burger" in Virginia and "Best Barbecue" in Texas 2Health News:Red Hot & Blue BBQ Restaurants Voted "Best Burger" in Virginia and "Best Barbecue" in Texas 3Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 2Health News:Recent Article Advocating for Breast Reconstruction with Fat Transfers Successfully Outlines the Advantages of Transfer Procedures, Notes Beverly Hills Physicians 3Health News:Join New Energy Works Timberframers in Raising the Frames in Western New York 2Health News:Join New Energy Works Timberframers in Raising the Frames in Western New York 3Health News:Join New Energy Works Timberframers in Raising the Frames in Western New York 4Health News:Atlanta Otolaryngologist Dr. Marcelo Antunes Joins Northwest ENT and Allergy Center 2Health News:Atlanta Otolaryngologist Dr. Marcelo Antunes Joins Northwest ENT and Allergy Center 3Health News:Correct Chemo Joins NextGxDx Online Genetic Testing Marketplace 2Health News:Correct Chemo Joins NextGxDx Online Genetic Testing Marketplace 3
... includes a boy, study finds , WEDNESDAY, Oct. 21 (HealthDay ... the infants, size and delivery date -- might be affected ... Sharing the womb with a female produces better results, in ... with a male, whether the other twin is male ...
... BOSTON and CAMBRIDGE--Cancer cells fueled by the mutant KRAS oncogene, ... by blocking a more vulnerable genetic partner of KRAS, report ... of Harvard and MIT. The laboratory results, published by ... online publication and later in a print edition, demonstrate a ...
... say they can protect healthy tissue , WEDNESDAY, ... may have found a way to protect healthy tissue ... radiation therapy. , The key is a biochemical signaling ... healthy and cancerous cells. In experiments with mice, the ...
... Four New Judges Will Speed Veterans, Appeals , ... Shinseki announced the addition of four new Veterans Law Judges ... the board to increase the number of cases being decided. ... professional review of their claims for benefits," Secretary Shinseki said. ...
... The International Serious Adverse Events Consortium (SAEC) announced today ... to improve the safe use of drugs by exploring ... more likely to experience serious drug-related adverse events (SAEs). ... consortium. The HMORN is the nation,s premier resource ...
... Oct. 21, 2009 The eyes may be the windows ... mirror a brain ravaged by Alzheimer,s disease. UC Irvine ... have Alzheimer,s undergo changes similar to those that occur in ... lesions. In addition, the scientists discovered that when Alzheimer,s ...
Cached Medicine News:Health News:Sex of Twins May Affect Outcomes 2Health News:Sex of Twins May Affect Outcomes 3Health News:Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells 2Health News:Researchers exploit genetic 'co-dependence' to kill treatment-resistant tumor cells 3Health News:Radiation Treatments Made Safer for Cancer Patients 2Health News:Secretary Announces Expansion of Veterans Appeals Board 2Health News:Research partnership will study how electronic medical records can address genetics of drug safety 2Health News:Alzheimer's lesions found in the retina 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: