Navigation Links
Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
Date:8/22/2007

- Revised Trial Examines Single, Higher, More Concentrated Dose of

Alfimeprase -

SAN CARLOS, Calif., Aug. 22 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced enrollment of the first patient in the SONOMA-3 (Speedy Opening of Non-functional and Occluded catheters with Mini-dose Alfimeprase-3) trial evaluating lead product candidate, alfimeprase, for the treatment of central venous catheter occlusion (CO).

This open-label, single-arm trial will evaluate the safety and efficacy of a single 10 milligram dose of alfimeprase with a concentration of 5 milligrams per milliliter in up to 100 patients with occluded central venous catheters.

Data from a previous Phase 3 trial in the CO program, SONOMA-2, showed that alfimeprase restored catheter function in patients with occluded catheters within 15 minutes with a p-value of 0.022. It did not however, meet the more stringent p-value required for a single pivotal trial, less than 0.00125.

"Analysis of data from our previous Phase 3 SONOMA study provided further evidence that alfimeprase is an active thrombolytic which has the potential to dissolve clots quickly and rapidly restore catheter function, however, the dose and concentration we used did not generate results in line with the target product profile we believe necessary for commercial success in this market," said Michael Levy, M.D., executive vice president of research and development for Nuvelo. "Preclinical experiments have provided evidence that increasing the concentration can result in marked improvement in thrombolytic activity. Accordingly, we are resuming development of alfimeprase in CO to evaluate the potential of a single, higher, m
'/>"/>

SOURCE Nuvelo, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Nuvelo Announces Presentations on rNAPc2 and NU172 at the XXIst Congress of the International Society on Thrombosis and Haemostasis
2. Nuvelo Announces Publication of Phase 2 rNAPc2 Study Results in Journal of American College of Cardiology
3. Nuvelo Announces Publication of Preclinical Study Results Demonstrating the Potential of NTB-A as a New Target for Leukemia and Lymphomas
4. Nuvelo Announces Publication of NU206 Study Results in Gastroenterology
5. Nuvelo Announces Presentation on NU206 at 2007 American Association for Cancer Research Annual Meeting
6. Nuvelo Announces Presentation on rNAPc2 at American College of Cardiology 56th Annual Scientific Session
7. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
8. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
9. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
10. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
11. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... , May 29, 2015 Educating ... of the Association for the Advancement of Wound ... With support from AAWC,s corporate partners, the ... Portal on the AAWC website at ... wound care pathway with links to various CME/CEU ...
(Date:5/28/2015)... Zimmer Holdings, Inc. (NYSE and SIX: ZMH) ... buyers to divest in the United States ... Biomet Discovery® Elbow System assets and Cobalt™ bone cement ... pending acquisition of Biomet, Inc. ("Biomet").  , ... with the Bureau of Competition Staff of the U.S. ...
(Date:5/28/2015)... 2015  Pharmaceutical companies and diagnostics companies ... and this is translating into a sizeable ... them. This according to Kalorama Information, a healthcare ... as mass spectrometry, electrophoresis and liquid chromatography ... drug targets and the validation of biomarkers, ...
Breaking Medicine Technology:The Association for the Advancement of Wound Care Educates the Public 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6Report: Proteomics Research Market Reaches $1.6 Billion 2Report: Proteomics Research Market Reaches $1.6 Billion 3
(Date:5/30/2015)... May 30, 2015 Twelve of the ... by their peers as the 2015 Giants of ... at the Chicago Illuminating Company last night. The awardees ... oncologists for landmark achievements in translational research, gene therapy, ... course of cancer treatment. , Honorees were introduced and ...
(Date:5/30/2015)... Michigan (PRWEB) May 30, 2015 NovaSure® ... to lighten or stop periods, without the side ... procedure can reduce or stop menstrual bleeding and works ... uterus (the part that causes the bleeding), with a ... women suffer from heavy menstrual bleeding. Many women ...
(Date:5/30/2015)... ProIntro Magnify contains 30 self-animating and minimalistic Titles including ... elegant opening title to any Final Cut Pro X ... layouts. ProIntro Magnify is created exclusively for Final Cut Pro ... Simply drag a preset into the FCPX timeline ... Inspector window then watch as ProIntro Magnify does the rest. ...
(Date:5/30/2015)... CA (PRWEB) May 30, 2015 The ... Services in coordination with ONEgeneration Senior Enrichment Center, headed ... Manager Raymond de Guzman and Brain Fitness Program Director ... joined this event learned that there are many ways ... Tee Bar showed the residents the different ways to ...
(Date:5/30/2015)... The iconic American actor, and host of “In ... segment on Medical Malpractice. This segment of “In America” ... health care field. , According to the Bureau of ... were filed, roughly only 20% of them made it ... while the remaining 30% were tossed out. (Source: ...
Breaking Medicine News(10 mins):Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 2Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 3Health News:OncLive’s 2015 Giant of Cancer Care™ Awards Announced 4Health News:Women's Excellence Now Provides NovaSure Treatment 2Health News:Announcing the release of ProIntro Magnify from Pixel Film Studios. 2Health News:1Heart Caregiver Services Brings Brain Fitness Education Seminar at ONEgeneration 2Health News:1Heart Caregiver Services Brings Brain Fitness Education Seminar at ONEgeneration 3
... suggests that the presence of tumor cells in the circulating ... and neck may predict disease recurrence and reduced survival. An ... a worse outcome. Those are the early ... of CTCs by a team of researchers at The Ohio ...
... , TUESDAY, Dec. 21 (HealthDay News) -- Certain ... fat, according to an animal study that might one day ... tests on mice, a team at the Joslin Diabetes Center ... caused progenitor cells in subcutaneous (just beneath the skin) white ...
... with locally advanced head and neck cancers who successfully ... so without losing the ability to speak clearly and ... Institute. "This is good news," said Joseph K. ... Duke and the corresponding author of the study. "I ...
... robotic surgery for upper airway and digestive track malignant ... techniques based on patient function and survival, according to ... neck squamous cell carcinomas account for about 4 percent ... year. Currently the standard minimally invasive surgery for these ...
... HealthDay Reporter , MONDAY, Dec. 20 (HealthDay News) ... for strict heart rate control in patients with atrial ... strokes. More lenient management of the condition is ... guidelines from the American College of Cardiology and the ...
... , MONDAY, Dec. 20 (HealthDay News) -- ... swallow after undergoing combined chemotherapy and radiation treatment, but ... have found. The new study included patients who ... treated with chemoradiotherapy for advanced head and neck cancer. ...
Cached Medicine News:Health News:Tumor cells in blood may signal worse prognosis in head and neck cancer patients 2Health News:Factors linked to speech/swallowing problems after treatment for head and neck cancers 2Health News:Robotic surgery for head and neck cancer shows promise 2Health News:Guidelines Eased for Patients With Irregular Heartbeats 2Health News:Guidelines Eased for Patients With Irregular Heartbeats 3Health News:Speech, Swallowing Usually OK After Head & Neck Cancer Therapy 2
Double ended lasik spatula with flattened tip for lifting and smoothing the corneal flap. The sharp tip is useful to outline a previous flap in preparation for retreatment....
Delicate membrane spatula with serrated rake tip. 20 gauge shaft with balanced titanium handle. Dark finish for reduced glare....
Wedge-shaped chopper designed to allow nucleus chopping in three directions, tip length 1.25 mm. Rounded tip highly polished to protect the posterior capsule. 0.5 mm spatula end is used to manipulate...
11 mm angled tip with gently curved blade. Flat serrated handle with polished finish....
Medicine Products: