Navigation Links
Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
Date:1/30/2008

SAN CARLOS, Calif., Jan. 30 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced that it has enrolled the first patient in a single-center, Phase 1 trial to determine the safety, tolerability and pharmacokinetics of escalating doses of NU172, a thrombin-inhibiting aptamer, in approximately 30 healthy male volunteers.

"This proof-of-concept trial will allow us to quickly determine NU172's potential to achieve rapid onset and offset of anticoagulation," said Michael Levy, executive vice president of research and development for Nuvelo. "We look forward to sharing top-line data from this trial in the first half of 2008."

NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to foreign materials. Specifically, NU172 is being studied for use as a potential short-acting anticoagulant during procedures such as coronary artery bypass graft surgery and percutaneous interventions. Data from early animal models suggest that NU172 has the potential for predictable anticoagulant effects, rapid onset and offset of action, and avoidance of heparin-induced thrombocytopenia.

About Aptamers

Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to antibodies. Characteristics of aptamers include high specificity and affinity, and the ability to target protein-protein interactions.

About Nuvelo and Archemix's Joint Collaborative Effort

In August 2006, Nuvelo expanded its collaboration with Archemix to develop and commercialize aptamers that have a sho
'/>"/>

SOURCE Nuvelo, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke
2. Nuvelo Announces Alfimeprase SONOMA-2 Catheter Occlusion Data Presentation Webcast and Conference Call
3. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
4. Northwestern Memorial Transplant Program Initiates New Study
5. Cerimon Pharmaceuticals Initiates Phase II/III Clinical Studies to Evaluate its Diclofenac Patch for Mild to Moderate Pain
6. SGX Initiates Phase I Trials for SGX523
7. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
8. Arena Pharmaceuticals Announces Positive Phase 1a Clinical Trial Results of APD791 for the Treatment of Arterial Thrombosis and Initiates Phase 1b Clinical Trial
9. Corthera Initiates Phase II Clinical Trial of Relaxin in Acute Heart Failure
10. Trius Initiates U.S. Phase I Trial for its Oxazolidinone Antibacterial Drug, TR-701
11. Sangart, Inc. Initiates Dosing in Phase II Study of Hemospan(R) in Chronic Critical Limb Ischemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... -- Does your doctor know what you,re smoking?  Chances are, ... to the over 112,000 currently registered patients under ... other roughly 20,300+ active physicians listed with the Colorado Dept ... even though a poll in February 2014 showed 51% of ... it. "With marijuana legalization underway, every doctor ...
(Date:8/29/2014)... Diseases largely eradicated in the ... Measles was declared eliminated in 2000, yet the CDC ... 15—the highest incidence in 20 years. In July, ... cough a problem of "epidemic proportions." ... from these preventable diseases—in part because some parents (more ...
(Date:8/29/2014)... , Aug. 29, 2014  Abaxis, Inc. (NasdaqGS: ... blood instrumentation and consumables to the medical, research and ... Chairman and Chief Executive Officer, will present at the ... 2014 on Tuesday, September 9, 2014 at 12:30 p.m. ... Berkshire Place Hotel in New York City ...
Breaking Medicine Technology:Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 2Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 3Medical Rules Marijuana Sales in Colorado But Most Doctors Still in the Dark 4Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2
... ALTO, Calif., Nov. 13 Telik, Inc. (Nasdaq: TELK ) ... share, for the third quarter ended September 30, 2009, compared with ... the comparable period in 2008. , For the quarter ended September ... with $7.8 million in the 2008 third quarter. Operating expenses ...
... Millar Instruments, Inc., developer and manufacturer of Mikro-Tip® ... Transonic Systems, Inc., global leader in the design, ... announce a new distribution partnership. , "I am ... field of physiological measurements, Transonic Systems and Millar ...
Cached Medicine Technology:Telik Announces Third Quarter 2009 Financial Results 2Telik Announces Third Quarter 2009 Financial Results 3Millar Instruments and Transonic Systems, Suppliers of Gold Standard Pressure and Flow Products, Enter Into Mutual Distribution Agreement 2
(Date:8/30/2014)... Recently, Top 10 Best SEO Hosting (Top10BestSEOHosting.com) has ... BlueHost and JustHost ( http://www.justhost.com/track/seohosts ) are great ... high quality web hosting. , “The hosting ... companies who outperform their competitors on hosting features, ... spokesman for Top 10 Best SEO Hosting says, ...
(Date:8/30/2014)... 2014 Recently, iFitDress.com, one of the ... designs of classy bridesmaid dresses . For additional ... 22 percent off to 62 percent off) for all ... items. , True enough, iFitDress.com is an industry ... gowns. The company persists in making trendy products that ...
(Date:8/30/2014)... August 31, 2014 Fast hosting ... websites. Top10BestSEOHosting.com has recently compared many professional web ... http://www.hostmonster.com/track/seohosts ) and Arvixe are the suppliers of ... hard to find a good fast hosting supplier. ... hosting features, uptime, server speed and customer support. ...
(Date:8/30/2014)... 31, 2014 Recently, Skmen.com, a well-known ... long casual dresses . Before the middle of September, ... a discounted price, from 15 to 30 percent off. ... company’s long casual outfits are carefully made and come ... look for the wearers. Skmen.com is popular for its ...
(Date:8/30/2014)... Information supplied by insurance companies has been helping ... consumers in 2014. A group of ratess for term ... open system for adults at http://quotespros.com/life-insurance.html . ... year can help the average person to quote a ... from medical histories. The finder tool works under a ...
Breaking Medicine News(10 mins):Health News:Great Web Hosting Suppliers Recently Recommended by Top10BestSEOHosting.com 2Health News:Classy Bridesmaid Dresses Announced By Loved Online Supplier iFitDress.com 2Health News:Fastest Web Hosting Suppliers In 2014 Announced By Top10BestSEOHosting.com 2Health News:Huge Deals On 2014 Long Casual Dresses Unveiled By Skmen.com 2Health News:Term Life Insurance Rates Now Found Nationally by New Insurer Finder Tool 2
... 27, 2008 Overweight Hispanic children with normal blood glucose ... may predispose them to developing both type 2 diabetes and ... the Joslin Diabetes Center. , The study, published in the ... on Hispanic children, already known to be at high risk ...
... the United States government should convert the Guantanamo ... research institute dedicated to combating diseases of poverty. ... Neglected Tropical Diseases, Editor-in-Chief Peter Hotez says that ... position to directly address the poverty-promoting diseases and ...
... Disputes, SPOKANE, Wash., Feb. 26 Recently, ... settlement on four,outstanding disputes. The approximately 110 nurses ... "This settlement is very important for the nurses, ... refusal to negotiate a fair,contract," said Buck Holliday, ...
... 26 Local communities,can be effective in preventing ... and heart disease if they use healthy eating ... principles identified by,leading national programs., Communities are ... nation. There are eight leading national programs which ...
... (Nasdaq: IDIX ) announced today that Idenix management,will ... in Healthcare Conference hosted by Susquehanna Financial Group on,Wednesday, ... W Hotel in the Sea/Ocean,Room in New York, NY., ... the company presentation,can be accessed under "Calendar of Events" ...
... Additional Benefit Found for Personalized Intervention to Promote ... interventions did not significantly increase regular mammography screening ... such as personalized mailings, have been reported to ... examined the impact of behavioral interventions on regular ...
Cached Medicine News:Health News:Overweight Hispanic children shown to have vascular inflammation 2Health News:From detainee facility to health advocacy center: A new role for Guantanamo? 2Health News:Nurses Convince Hospital to Return to Bargaining Table 2Health News:Effective Healthy Eating and Physical Activity Initiatives Can Reduce Health Disparities 2Health News:Other highlights in the Feb. 26 JNCI 2Health News:Other highlights in the Feb. 26 JNCI 3Health News:Other highlights in the Feb. 26 JNCI 4
... Soft amber latex. Available in even ... nasal airway maximizing patient comfort., ... way to maximize patient comfort while ... sensitivity. It is economically priced allowing ...
Soft PVC. Available in sizes 12-36F, Interior striations for smooth suction catheter insertion. Bevel tip. Single use. Sterile....
Soft Guedel Oral Airways...
... of difficult airways., ,When a difficult ... are critical. Now you can be assured ... the Combitube®: Esophageal/Tracheal double-Lumen Airway from Nellcor. ... is designed to establish a nonsurgical patient ...
Medicine Products: