Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ische... (nt of researchand development for Nuvelo...)

Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke

Date:12/12/2007

nt of research and development for Nuvelo.

With approximately 700,000 cases in the United States per year, stroke is the third leading cause of death and a leading cause of severe, long-term disability. Every 45 seconds someone has a stroke, and every three minutes someone dies of one. A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain becomes blocked by a blood clot (ischemic stroke) or ruptures (hemorrhagic stroke). This interruption in the blood and oxygen supply, to part of the brain, results in cell death and loss of function.

"There is a need for new and more effective approaches to stroke therapy for patients who present more than three hours after onset of symptoms," said Dr. Lawrence Wechsler, professor of neurology and neurological surgery at the University of Pittsburgh Medical School and director of the University of Pittsburgh Medical Center Stroke Institute. "Alfimeprase could be well suited for this particular setting as it is a clot-dissolver that holds the potential to directly and rapidly dissolve blood clots while keeping its activity localized to the site of delivery. We look forward to conducting this proof-of-concept trial to determine if alfimeprase's unique attributes translate into positive study outcomes for this patient population."

About Alfimeprase

Alfimeprase is a recombinant direct acting fibrinolytic (rDAF) that has the potential to rapidly dissolve blood clots through a unique mechanism of action -- it directly degrades fibrin, a protein that provides the scaffolding for blood clots. In addition, alfimeprase's thrombolytic activity appears to be localized to the site of delivery because it is rapidly inactivated by alpha-2 macroglobulin, a naturally occurring protein in the blood, as it moves away from the site of delivery and into the general blood circulation.

In addition to acute ischemic stroke, alfimeprase is also being evaluated as a potential treatment for cath
'/>"/>

SOURCE Nuvelo, Inc.
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4
Related medicine technology :

1. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
2. Nuvelo Announces Alfimeprase SONOMA-2 Catheter Occlusion Data Presentation Webcast and Conference Call
3. Par Pharmaceutical Begins Shipment of Additional Dosage Strength of Generic TOPROL-XL(R)
4. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
5. Enrollment Begins on Human PK Study for Medidur(TM) FA
6. Vical Begins Phase 1 Trial of DNA Vaccine Against H5N1 Pandemic Influenza
7. Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)
8. Rockwell Medical Technologies, Inc. Begins Patient Enrollment for its SFP Dose-Ranging Study
9. Metabolex Begins Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia
10. DiObex Begins Dosing Patients in Phase 2b Trial of Type 2 Diabetes Drug
11. Rockwell Medical Technologies, Inc. Begins Dosing Patients for SFP Phase IIb Clinical Study

Post Your Comments:

(Date:5/24/2013)... , May 24, 2013 Heska Corporation (NASDAQ: HSKA, ... and specialty products, announced today that Dr. Robert ... and Jason Napolitano , executive vice president ... Marcum MicroCap Conference, which is being held May 30, 2013 ... Grand Hyatt Hotel. The Company,s presentation is ...

(Date:5/24/2013)... In accordance with Rule 17.1 and Rule 2.9 ... United States Exchange Act, Echo Pharma Acquisition Limited ("Royalty Pharma") ... (NYSE: ELN). Background On 2 May ... for the entire of the issued and to be issued ... On 20 May 2013, Royalty Pharma announced ...

(Date:5/24/2013)... England and BOSTON , ... GPCR drug discovery and development company, is pleased to announce that ... a Consultant to augment the Company,s business development capabilities in ... Usui has more than 15 years of experience in business development, ... at Perlegen Sciences, Inc., Roche Pharma ( Japan ), ...

[0] Heska Corporation To Present At The Second Annual Marcum LLP MicroCap Conference [0] Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements [0] Heptares Augments Business Development Capabilities in Japan and Other Asian Territories

... PRINCETON, N.J., Sept. 13, 2011 Kremers Urban Pharmaceuticals ... a settlement dismissing all pending litigation arising from its ... release methylphenidate hydrochloride product, for which Concerta® is the ... with FDA. The settlement includes a ...

... BALTIMORE, Sept. 13, 2011 Champions Oncology, Inc. formerly ... Fiscal Year 2012 First Quarter Financial ... 2012 were $1.63 million compared to $1.60 million in ... for the first quarter of fiscal 2012 were $3.85 ...

Cached Medicine Technology:Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 2 Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 3 Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 4 Champions Oncology Reports Fiscal 2012 First Quarter Financial Results 5

Kremers Urban Pharmaceuticals Inc. Settles Concerta® Patent Litigation Champions Oncology Reports Fiscal 2012 First Quarter Financial Results

(Date:5/25/2013)... (PRWEB) May 25, 2013 On May 20, ... people do not wish to discuss or plan for their ... FuneralFinancials.com released a Must-Do List to help ... Funeral Financials recommends, “Creating a personal fact sheet.” , While ... organize financial information and personal data. It may include ...

(Date:5/25/2013)... 25, 2013 The latest report ... irritable bowel syndrome (IBS) to bloating, constipation, diarrhea ... most long-lasting, embarrassing, frustrating and difficult health issues ... digestive health have provided a cure for ... factors contributing to digestive health issues, a healthy ...

(Date:5/25/2013)... On May 25, Voices Against Brain ... advocacy, comments on a new study by the Max ... atmospheric plasma into brain cancer treatment may help when ... Science Daily article, physicists from the Max ... demonstrated the “synergistic effect of cold atmospheric plasma -- ...

(Date:5/25/2013)... Many orthodontists have thought about moving ... that cloud is. Most people would naturally assume ... provide their cloud service and support would own and ... they're selling, they'd be wrong. Cloud providers lease ... redundant facility that houses servers and related equipment to ...

(Date:5/25/2013)... 2013 According to world-renowned scholars, Queen ... powerful women that ever lived. Cleopatra’s legendary beauty moved ... the most powerful men in her time. Cleopatra was ... keep her skin glowing and fresh, from her legendary ... maringa oil and cyprus grass. , Cleopatra was said ...

Breaking Medicine News(10 mins):Health News:FuneralFinancials.com Releases Last Wishes Must-Do List 2 Health News:Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org 2 Health News:Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells 2 Health News:Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other 2 Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 2 Health News:The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician 3

[0] FuneralFinancials.com Releases Last Wishes Must-Do List [0] Natural Foods For Digestive Health Report and Video Published by BetterDigestion.org [0] Voices Against Brain Cancer Comments on Study that Shows Cold Plasma’s Success Against Brain Cancer Cells [0] Cirrus Ortho Launches Cloud Computing for Orthodontic Industry That is Unlike Any Other [0] The Cleopatra Lift - A New Non Surgical Option to Aging Offered by Vancouver Physician

... Canadian study found new arrivals tended to be healthy , ... and the United States may be less likely to suffer ... new study has found. , University of Toronto researchers identified ... compared them with more than 3.2 million people who,d lived ...

... ... joined by the NAACP, American Diabetes Association and Greater Philadelphia Health Action, Inc and ... ... families are expected to attend the “Outreach Day” event on Thursday, February 4, 2010, ...

... , CINCINNATI , ... has been marked as the winningest in franchise history, with a first ... DREW BREES ( PURDUE ) consistent and dependable ... today. The New Orleans Saints offensive line was the first to be ...

... KNOXVILLE, Tenn. , Feb. 3 TeamHealth Holdings, Inc. ... of outsourced healthcare professional staffing and administrative services to hospitals and ... that the Company will release its fourth quarter and full fiscal ... 2010 , to be followed by a conference call on ...

... , WASHINGTON , Feb. 3 ... treat the victims of the devastating earthquake, the American Red Cross is ... the request of the Pan American Health Organization (PAHO). , (Logo: ... the shipment of 350 units of blood to Haiti – ...

... , , ... alerting the public about the following products: , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ... capsules (120-count refill kit) sold over the Internet contains a different ... have needles that detach from the syringe and could remain in ...

Cached Medicine News:Health News:Immigrants at Lower Stroke Risk Than Long-Term Residents? 2 Health News:More Than 250 Philadelphia Diabetics Expected to Attend "Outreach Day" 2 Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 2 Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 3 Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 4 Health News:New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R) 5 Health News:TeamHealth Holdings, Inc. Announces Fourth Quarter and Full Fiscal 2009 Earnings Release Date and Conference Call 2 Health News:TeamHealth Holdings, Inc. Announces Fourth Quarter and Full Fiscal 2009 Earnings Release Date and Conference Call 3 Health News:American Red Cross and Other U.S. Blood Centers Send Blood to Haiti 2 Health News:American Red Cross and Other U.S. Blood Centers Send Blood to Haiti 3 Health News:FDA Consumer Health Information - FDA's MedWatch Safety Alerts: January 2010 2

Immigrants at Lower Stroke Risk Than Long-Term Residents?More Than 250 Philadelphia Diabetics Expected to Attend "Outreach Day"New Orleans Saints Offensive Line Honored with First Madden Most Valuable Protectors Award Presented by Prilosec OTC(R)TeamHealth Holdings, Inc. Announces Fourth Quarter and Full Fiscal 2009 Earnings Release Date and Conference Call American Red Cross and Other U.S. Blood Centers Send Blood to Haiti FDA Consumer Health Information - FDA's MedWatch Safety Alerts: January 2010

Lumbar External Drainage System (LED) with Touhy needle is indicated for temporary access to the Lumbar Subarachnoid region as a means of draining cerebral spinal fluid (CSF) in order to reduce incre...

Monitorr ICP external CSF drainage and monitoring system with patient line one way valve....

Skull Traction Tongs for cervical vertebra extension, adjustable pins, eliminates need for preliminary drilling, large pattern, complete with wrench...

Cushing Flat Drill, only Component Parts and Accessories for HUDSON Cranial Drill. 14 mm...

Medicine Products:

Lumbar External Drainage System (LED)Monitorr ICP External CSF Drainage and Monitoring System Skull Traction Tongs Cushing Flat Drill