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Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172
Date:4/29/2008

said Dr. Ted W. Love, chairman and chief executive officer of Nuvelo. "We plan to launch a Phase 1b trial of bolus dosing followed by escalating infusion doses of NU172 later this quarter, which should enable us to quickly begin a Phase 2 study evaluating NU172 in medical or surgical procedures in the fourth quarter of 2008 or the first quarter of 2009."

According to the American Heart Association, more than 450,000 coronary artery bypass graft (CABG) procedures and more than 1.2 million percutaneous coronary interventions (PCIs) are performed annually in the United States. Heparin, which must be paired with its antitode protamine for reversal, is the current standard of care for anticoagulation in CABG surgeries and PCI.

About Aptamers and NU172

Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to antibodies. Characteristics of aptamers include high specificity and affinity, and the ability to target protein-protein interactions.

NU172 is an aptamer designed to directly inhibit thrombin's ability to stimulate blood clot formation in the setting of medical procedures where human blood is exposed to foreign materials. Specifically, NU172 is being studied for use as a potential short-acting anticoagulant during procedures such as coronary artery bypass graft surgery and percutaneous interventions. Data from the Phase 1 trial and preclinical studies suggest that NU172 has the potential for predictable anticoagulant effects, rapid onset and offset of action, and avoidance of thrombocytopenia.

About Nuvelo and Archemix's Joint Collaborative Effort

In August 2006, Nuvelo expanded its collaboration with Archemix to develop and commercialize aptamers that have a short-acting anticoagulant effect. Under the agreement, Archemix is responsible for discovery of short-acting aptamers for use in
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SOURCE Nuvelo, Inc.
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