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Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172
Date:4/29/2008

- Subsequent Phase 1b study planned for mid 2008 with Phase 2 development

to begin late in 2008 or in early 2009 -

SAN CARLOS, Calif., April 29 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced positive results from the Phase 1 proof-of-concept trial (n=30) of NU172, demonstrating that the thrombin-inhibitor achieved rapid onset and offset of anticoagulation after a single bolus dose with a favorable safety profile.

"There is a significant need for anticoagulants with fewer side effects and more predictable dosing than treatments currently available today," said David J. Schneider, M.D., professor of medicine and director of cardiology and vascular biology at the University of Vermont. "NU172 represents a new approach to anticoagulation for medical and surgical procedures through its potential to produce rapid and predictable onset of anticoagulation followed by rapid reversal once the infusion is discontinued."

The single-center, Phase 1 trial examined the safety, tolerability and pharmacokinetics of escalating bolus doses of NU172 in normal, healthy volunteers. In the trial, NU172 produced dose-dependent increases in anticoagulation, measured by activated clotting time (ACT). The 2.00 mg/kg bolus dose of NU172 achieved target ACTs of approximately 400 seconds. Upon withdrawal of NU172 the ACT showed a rapid return toward baseline with a plasma half-life of NU172 of approximately 10 minutes. No serious adverse events occurred in the trial.

"We are very encouraged by these findings and NU172's potential to address the need for rapid onset and offset of anticoagulation in medical procedures such as coronary artery bypass graft surgery and percutaneous coronary intervention,"
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SOURCE Nuvelo, Inc.
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