Navigation Links
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172
Date:8/14/2008

e (aPTT). The highest infusion dose rate tested, 6.0 mg/kg/hr, resulted in an average ACT per subject ranging from 373 to 414 seconds and an increase of approximately three times baseline. Average PT values per subject ranged from 56 to 92 seconds and had an increase of approximately five times baseline. Average aPTT values per subject ranged from 130 to 178 seconds and had an increase of approximately five times baseline. All measurements were maintained stably throughout the four-hour infusion. Once the infusion ended, the ACT and other coagulation parameters showed a rapid return toward baseline, consistent with the short plasma half-life of NU172 observed in the Phase 1a trial. In addition, NU172 was well-tolerated with no serious adverse events.

"In this study, we were able to identify a dose that meets or exceeds the level of anticoagulation needed for the indications we plan to evaluate, including CABG surgery," said Dr. Ted W. Love, chairman and chief executive officer of Nuvelo. "In addition to supporting our previous proof-of-concept data, the Phase 1b study shows that anticoagulation with NU172 can be maintained for four hours, which is longer than a typical CABG procedure. We are on track to launch a Phase 2 study evaluating NU172 in the fourth quarter of 2008 or the first quarter of 2009."

Approximately 450,000 CABG procedures, 50 million dialysis procedures, and 1.2 million PCIs are performed annually in the U.S. During these procedures, anticoagulants are given to prevent blood clotting. In CABG procedures and often in dialysis, the anticoagulation effect of heparin must be reversed with protamine once the procedure has been completed.

About Aptamers and NU172

Aptamers are chemically synthesized single-stranded nucleic acids that form well-defined three-dimensional shapes, allowing them to bind target molecules in a manner that is conceptually similar to antibodies. Characteristics of aptamers include high specificity and a
'/>"/>

SOURCE Nuvelo, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172
2. Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172
3. Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models
4. Nuvelo Announces Phase 2 SONOMA-3 Trial Did Not Meet Target Product Profile and Discontinues Alfimeprase Development
5. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
6. Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke
7. Nuvelo Announces Alfimeprase SONOMA-2 Catheter Occlusion Data Presentation Webcast and Conference Call
8. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
9. NewCardio Announces Positive Results From Third Clinical Validation Study
10. Medarex Announces Initiation of Phase 2 Clinical Development Program for the Treatment of Lupus
11. Lixte Biotechnology Holdings Announces Filing of a New Patent Application for the Use of Novel Compounds as Potential Treatment for Neurodegenerative Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the pharmaceutical, biotechnology, and medical ... and the United States , ... the Tel Aviv area of ... WuXi,s broad platform of integrated R&D services to local ...
(Date:10/30/2014)... Boston Scientific Corporation (NYSE: BSX ... Suisse Annual Healthcare Conference on Tuesday, November 11, 2014 ... Brennan , executive vice president and chief financial officer, ... approximately 8:00 a.m. PT followed by a question and ... presentation and question and answer session will be available ...
(Date:10/30/2014)... , Oct. 30, 2014   ViaDerma, Inc. ... to bringing new products to market, has recently ... TetraStem. TetraStem is a topical liquid tetracycline-based antibiotic ... that can convert oral medication active ingredients into ... a first aid antibiotic to help prevent skin ...
Breaking Medicine Technology:WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3
... 27, 2011 Pepto-Bismol announced today that for the second ... white and … PINK? In an act of true gastro-patriotism, ... Nathan,s Famous Fourth of July International Hot Dog Eating Contest ... To make this contest a celebration to remember, Pepto-Bismol has ...
... Recent findings published in the scientific journal Leukemia ... with standard anti-leukemia agents, the biological activity of Leukothera ... Biomed, Inc., showed synergistic anti-leukemia effects. ... demonstrated that combining Leukothera TM with ...
Cached Medicine Technology:Pepto-Bismol and Nick Cannon Heat Things up at this Year's Nathan's Famous Fourth of July International Hot Dog Eating Contest 2Pepto-Bismol and Nick Cannon Heat Things up at this Year's Nathan's Famous Fourth of July International Hot Dog Eating Contest 3Recent Study Shows Leukothera™ Combined with Other Agents Has Enhanced Anti-Leukemia Effects 2
(Date:10/31/2014)... 31, 2014 — A team from the Broad ... University of California, Santa Cruz, was awarded one ... Cloud Pilot contracts with the goal of building ... The Cancer Genome Atlas (TCGA) and other datasets ... resources in one cloud environment. This co-location will ...
(Date:10/31/2014)... Daily Gossip writes in its Xtreme Fat Loss review that ... loss program ever developed. It promises to provide users the ... no wonder after all that this has become the most ... and workout fat loss program was created by Joel Marion, ... the author of this fat loss system, the method can ...
(Date:10/31/2014)... Thousand Oaks, CA (PRWEB) October 31, 2014 ... flat tummy also has amazing health effects for ... were created by a Doctor of Science and ... discovered through his dedication to pelvic floor reeducation ... incidence of urinary incontinence, Diastasis Recti, Prolepses, etc. ...
(Date:10/31/2014)... October 31, 2014 With all the ... Midwest optometrist feels they may overlook one critical area ... areas like concentration, school performance and even behavior. Typical ... brief to identify progressive vision problems, and to address ... announces a new initiative: The Awesome Eyes Student Vision ...
(Date:10/31/2014)... Energy Textiles has recently added a new line ... available online, and Energy Textile is providing their customers ... gear over compression gear. , The Boston Globe ... for Under Armour to provide team gear for the ... light of this decision, Energy Textiles contemplates whether or ...
Breaking Medicine News(10 mins):Health News:Broad Institute, Univ. of California team awarded NCI Cancer Genomics Cloud Pilot contract 2Health News:Broad Institute, Univ. of California team awarded NCI Cancer Genomics Cloud Pilot contract 3Health News:Xtreme Fat Loss Diet Review Reveals How to Transform Your Body in 25 Days 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 2Health News:Super Models and European Celebrities’ Secret Flat Tummy System Comes to America 3Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 2Health News:New School Vision Initiative Announced by Dr. Rosenak’s Optical Options; Program Aims to Help Recognize Unseen Vision Problems That Impact School Success 3Health News:Compression Gear--Is There a Better Alternative? 2Health News:Compression Gear--Is There a Better Alternative? 3Health News:Compression Gear--Is There a Better Alternative? 4
... Jan. 19 (HealthDay News) -- Many U.S. transplant surgeons ... to develop new safeguards that would protect and inform ... of transplant surgeons in the nation "overreacted" to a ... HIV after receiving organs from a single donor unknowingly ...
... 2011) Cancer scientists led by Dr. John Dick ... St Jude Children,s Research Hospital (Memphis) have found that ... them are organized in a more complex way than ... Nature (DOI:10.1038/nature09733), challenge the conventional scientific view ...
... By Charnicia Huggins HealthDay Reporter , ... tongue piercing as a form of self-expression, know that ... metal or plastic makes a difference when it comes ... collect more bacteria than plastic studs, potentially increasing the ...
... Physical Review X (PRX), an online, open access, primary ... As broad in scope as physics itself, PRX will publish ... will be of value to the global multidisciplinary readership. PRX ... an open access venue in accord with the strong reputation ...
... Ont., Jan. 19, 2011Health care systems around the world ... making decisions, causing inefficiencies and reduced quantity and quality ... field of "knowledge translation." "Failures to use research ... decision-maker groups," said Dr. Sharon Straus, a geriatrician and ...
... the world have been hot on the trail of a ... since the mutation,s discovery in 2008. The hunt is now ... Cancer Cell , researchers reveal how the mutation contributes to ... About 75 percent of people with low-grade brain tumors ...
Cached Medicine News:Health News:Cancer scientists discover genetic diversity in leukemic propagating cells 2Health News:Cancer scientists discover genetic diversity in leukemic propagating cells 3Health News:Metal Tongue Piercings Linked to Raised Infection Risks 2Health News:Metal Tongue Piercings Linked to Raised Infection Risks 3Health News:American Physical Society announces Physical Review X 2Health News:Health-care systems not using best evidence in decision-making 2Health News:Molecular battle in cancer cells offers clues for treatment 2
Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Stat Detection of Soluble Fibrin Monomer Complexes by the Hemagglutination Technique, 32 tests....
Batch Detection of Soluble Fibrin Monomer Complexes by the Hemagglutination Technique, 40 tests....
For use with catalog #0454....
Medicine Products: