Navigation Links
Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172
Date:8/14/2008

- Phase 2 development to begin in late 2008 or in early 2009 -

SAN CARLOS, Calif., Aug. 14 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO) today announced positive results from the Phase 1b proof-of-concept trial of NU172, demonstrating that the direct thrombin inhibitor rapidly produced and maintained anticoagulation with a rapid return toward baseline after the infusion ended with a favorable safety profile.

"NU172 has the potential to address many of the limitations of currently available anticoagulants given the profile we have seen to date in preclinical and Phase 1 testing, including its ability to produce rapid and predictable onset and offset of anticoagulation without the need for an antidote, its potential ability to work in stagnant blood, its predominately non-renal clearance, and the option to stop and restart anticoagulation as needed during or after surgery," said A. Michael Lincoff, M.D., vice chairman of the department of cardiovascular medicine and an interventional cardiologist at the Cleveland Clinic. "Because of these characteristics, NU172 could potentially offer an improved approach to anticoagulation for procedures such as coronary artery bypass graft (CABG) surgery, kidney dialysis, and percutaneous coronary intervention (PCI)."

The single-center, Phase 1b trial examined the safety, tolerability and pharmacokinetics of intravenous bolus plus infusion dosing of NU172, in 24 healthy male volunteers. Volunteers were given a 2 mg/kg bolus dose followed by escalating infusion doses of NU172 for four hours. In all four cohorts, NU172 produced dose-dependent increases in anticoagulation, measured by activated clotting time (ACT), prothrombin time (PT) and activated partial thromboplastin tim
'/>"/>

SOURCE Nuvelo, Inc.
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172
2. Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172
3. Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models
4. Nuvelo Announces Phase 2 SONOMA-3 Trial Did Not Meet Target Product Profile and Discontinues Alfimeprase Development
5. Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172
6. Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke
7. Nuvelo Announces Alfimeprase SONOMA-2 Catheter Occlusion Data Presentation Webcast and Conference Call
8. Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion
9. NewCardio Announces Positive Results From Third Clinical Validation Study
10. Medarex Announces Initiation of Phase 2 Clinical Development Program for the Treatment of Lupus
11. Lixte Biotechnology Holdings Announces Filing of a New Patent Application for the Use of Novel Compounds as Potential Treatment for Neurodegenerative Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... Dec. 14 Authentidate Holding Corp. ... of secure Health Information Exchange and workflow ... of the Carolinas ("HCC"), a home health ... durable medical equipment supplier, have selected Authentidate,s ... standardize processes for the completion of patient ...
(Date:12/14/2009)... Dec. 14 According to Millennium Research ... market intelligence, increased use of safety devices for ... be a key driver of the enteral feeding ... MRG,s new US and European Markets for ... the giving set segment will experience the greatest ...
(Date:12/14/2009)... Incorporated (Nasdaq: ARAY ), a global leader ... the first CyberKnife® Robotic Radiosurgery System in Belgium ... Liege. ,, The University Hospital in Liege, ... hospitals in Euregio, a cross-country region of 18 ... of cancer treatments, University Hospital of Liege is ...
Breaking Medicine Technology:Home Care of the Carolinas and Alliance Medical, Inc. Select Authentidate's Inscrybe Healthcare to Improve Care Order Processing 2Home Care of the Carolinas and Alliance Medical, Inc. Select Authentidate's Inscrybe Healthcare to Improve Care Order Processing 3Home Care of the Carolinas and Alliance Medical, Inc. Select Authentidate's Inscrybe Healthcare to Improve Care Order Processing 4Enteral Feeding Device Market To Generate More Than $700 Million in the US & Europe by 2014 2Enteral Feeding Device Market To Generate More Than $700 Million in the US & Europe by 2014 3First CyberKnife in Belgium to be Installed at Leading University Hospital 2First CyberKnife in Belgium to be Installed at Leading University Hospital 3Give Life for the Fourth of July 49555 1Give Life for the Fourth of July 49555 2Give Life for the Fourth of July 49555 3Researchers uncover approach for possibly eradicating HIV infection 49554 1Researchers uncover approach for possibly eradicating HIV infection 49554 2The battle for CRTC2 3A How obesity increases the risk for diabetes 8937 1The battle for CRTC2 3A How obesity increases the risk for diabetes 8937 2The battle for CRTC2 3A How obesity increases the risk for diabetes 8937 3
... Medcompare.com ,According to a November, 2005 joint press ... the World Health Organization, the number of people living with ... in 2005, with over 3 million deaths caused by AIDS. ... shows that over one million people in the United States ...
... Beth Wegerbauer Contributing Editor ,According to the American ... 2002 was estimated to be $132 billion, or one out ... States. A chronic disease with no cure, diabetes is a ... marked by high levels of blood glucose resulting from defects ...
Other Medicine Technology:Rapid HIV Testing Increases Possibility of Treatment 2Rapid HIV Testing Increases Possibility of Treatment 3Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control 2Diagnosing Diabetes: Immediate HbA1c Results Improve Glycemic Control 3
(Date:12/14/2009)... Calif., Dec. 14 Tough Enough To Wear ... breast cancer, celebrated its fifth anniversary at the ... the Wrangler National Finals Rodeo (Wrangler NFR) in ... with rough-and-tumble rodeo cowboys, the support of the ... the sold-out crowd sported pink shirts, hats, bracelets ...
(Date:12/14/2009)... Lee Kurisko practiced in Canada for 13 years under government controlled ... in a free-market economy. In speaking engagements and in his new ... America of the fragility of such a system and its threat ... ... 2009 -- Lee Kurisko , a diagnostic radiologist from Minnesota, ...
(Date:12/14/2009)... Ohio, Dec. 14 Skilled nursing facilities (SNFs) ... services in order to deal with a 92 percent ... fee) from $6.25 to $12.01 per bed per day, ... the average facility will pay an additional $17,520 to ... a total tax of $438,365 yearly. ,, Nearly 96 ...
(Date:12/14/2009)... Ellis Healthcare REIT II, Inc. announced today that its board ... record as of the close of business on each day ... on Feb. 28, 2010. The distributions will be calculated ... be equal to an annualized distribution rate of 6.5 percent, ... distributions will be aggregated and paid in cash monthly in ...
(Date:12/14/2009)... BOSTON, Dec. 14 When Kurth Krause, ... crew instructions for landing on the moon, he,was ... about anything.,Years later, Kurth realized there was one ... a kidney transplant and even though dialysis machines,would ... without a transplant. Kurth,wrote: "My wife is 69 ...
Breaking Medicine News(10 mins):Health News:Tough Enough To Wear Pink(TM) Celebrates Fifth Anniversary 2Health News:Tough Enough To Wear Pink(TM) Celebrates Fifth Anniversary 3Health News:Tough Enough To Wear Pink(TM) Celebrates Fifth Anniversary 4Health News:Canadian Doctor Warns Against Government-Run, Socialized Medicine and its Threat to Health Care and Freedom in America 2Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 2Health News:Survey Shows Tax Increase Forcing Ohio Skilled Nursing Facilities to Make Cuts 3Health News:Grubb & Ellis Healthcare REIT II Declares Initial Distribution 2Health News:Grubb & Ellis Healthcare REIT II Declares Initial Distribution 3Health News:69-Year-Old Grandmother Needing A Lifesaving Kidney Transplant Finds a Miracle on the Internet: a 25-Year-Old Living Altruistic Organ Donor Stranger 2Health News:69-Year-Old Grandmother Needing A Lifesaving Kidney Transplant Finds a Miracle on the Internet: a 25-Year-Old Living Altruistic Organ Donor Stranger 3
... 2 Global Med Technologies(R), Inc.,("Global Med" ... an international,e-Health, medical information technology company, today ... licensed its EdgeTrack Transfusion,Software, marketed as "Hemo ... -,Hopitaux de Paris ("AP-HP") hospitals, representing 23,000 ...
... Results from Phase II Trial of DU-176b in Atrial Fibrillation Included ... N.J., Dec. 2 Daiichi Sankyo, Inc. (TSE: 4568), today announced ... be presented at the 50th Annual Meeting of the American Society ... in San Francisco. The data accepted for the ASH meeting ...
... Companion uses location-based technology to help consumers stay one step ahead ... ... December 2, 2008 -- Matrixx Initiatives, Inc., makers of Zicam® Cold ... Companion mobile application for the T-Mobile G1™, the world,s first Android-powered ...
... to seniors , , DETROIT, ... acupuncture and chiropractic services to its Flexible Health Options Benefit ... list of services to promote wellness encourages Medicare beneficiaries to ... in their wallets. , , ...
... occupants can help keep driving safe, research shows , , TUESDAY, ... phone are more distracted and more prone to error than ... them in the car, a new report finds. , "We ... when you have a person sitting next to you who ...
... 2 MEDai, Inc., headquartered in,Orlando, FL, a ... module,to its existing suite of predictive modeling solutions. ... to evidence-based medicine,guidelines and alerts stakeholders when there ... module Risk Navigator Guidelines(TM) provides,real-time decision support at ...
Other Medicine News:Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 2Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 3Health News:Global Med Technologies(R)' European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals 4Health News:Daiichi Sankyo, Inc. Announces Three Studies of Oral Factor Xa Inhibitor DU-176b Accepted for the 50th Annual Meeting of the American Society of Hematology 2Health News:Daiichi Sankyo, Inc. Announces Three Studies of Oral Factor Xa Inhibitor DU-176b Accepted for the 50th Annual Meeting of the American Society of Hematology 3Health News:Zicam Launches "Cold & Flu Companion" Mobile Application 2Health News:Zicam Launches "Cold & Flu Companion" Mobile Application 3Health News:HAP Expands Medicare Advantage Options to Include Acupuncture and Chiropractic Services 2Health News:HAP Expands Medicare Advantage Options to Include Acupuncture and Chiropractic Services 3Health News:Car Cell Phone Use More Hazardous Than Chat With Passengers 2Health News:Car Cell Phone Use More Hazardous Than Chat With Passengers 3Health News:MEDai Evidence-Based Guideline Reporting Provides Decision Support at Point of Care 2
... a complete system of surgical instruments and ... fusion surgery. The system was designed in ... research and engineering with advanced materials, techniques ... different, and because the anatomy of the ...
... treating upper extremity fractures with intramedullary ... studies. , ,Intramedullary nailing using the ... the benefits of anatomic alignment, rigid ... and early rehabilitation of the injured ...
... innovative new system to help you meet ... The system's one-piece design creates a broad ... postoperative radiographic assessment. The slotted superior and ... central column and are flared outward for ...
... LV lead is designed to ensure ... procedure times, delivering a complete package ... QuickSite LV lead is a highly ... including such features as S-shaped fixation, ...
Medicine Products: