Navigation Links
Number of Patients With Dementia on the Rise

ANN ARBOR, Mich., July 6 /PRNewswire-USNewswire/ -- At 81, Alberta Sabin's mind is not as sharp as it used to be, and she knows it.

She frequently misplaces common items, forgets names and appointments, some of the most frustrating aspects of memory loss, she says.

"I had been looking for my cell phone for three days and would you believe I found it laying on the counter in plain sight?," Sabin says. "There it was and I thought why didn't I see it before?"

It is that frustration that motivated Sabin to participate in U-M sponsored research designed to better diagnose and treat dementia before it escalates.

Sabin is one of millions of Americans who experience memory loss and may eventually be diagnosed with dementia.

"This is an explosive disease," says Sid Gilman, M.D., director of the Alzheimer's Disease Research Center at University of Michigan Health System, who conducts research with Sabin and others in her community. "It's a horrible disease that robs people of their humanity. They forget their families and friends."

Roughly 50 percent of people who reach 85 will become demented, according to studies conducted by investigators at Rush Medical Center in Chicago.

By age 100, the number spikes to 60 percent. Of those who develop dementia, roughly 60 percent will prove to have Alzheimer's disease. It's predicted that the current number of patients with Alzheimer's disease in the United States is roughly 5 million. By the year 2050, it will grow to about 30 million, presenting a significant financial burden to the healthcare system.

Gilman and other researchers at the Michigan Alzheimer's Disease Research Center (MADRC), have a keen interest in patients like Sabin. The center first received grant support from the National Institutes of Health in 1989 and has continued to receive funding since.

Researchers at the MADRC have so far studied 80 patients in a project that has been going on for four years on the diagnosis of Alzheimer's at the earliest sign of cognitive dysfunction. Researchers would ultimately like to evaluate 120.

One of the goals of the research is to determine the best tool for the early diagnosis of Alzheimer's disease: PET scans or clinical evaluations. In addition to Alzheimer's disease, there are other possible diagnoses with early onset cognitive impairment, including multiple strokes, frontotemporal dementia, corticobasal degeneration, and the cognitive disorder associated with Parkinson's disease, which is termed dementia with Lewy bodies.

"The earliest possible treatment for Alzheimer's disease would be to the patient's greatest advantage," Gilman says.

PET, or positron emission tomography, is an imaging study that allows doctors to evaluate the use of certain substances by the brain. Normally, the brain uses glucose as a fuel. Using PET scans, doctors can image the amount of glucose used by the brain to determine whether there's a difference in brain use by the frontal lobe, temporal lobe or the parietal lobe.

PET gives the ability to make predictions as to those individuals who will go on from mild impairment of memory to developing Alzheimer's disease. These patients may then qualify to participate in clinical trials for medications that treat Alzheimer's. Studies with glucose are being supplemented by PET scans that can image beta-amyloid, one of the abnormal proteins in the brain in Alzheimer's disease.

Sabin, whose mother and grandmother had dementia, is participating in U-M research that will help researchers diagnose and treat the illness earlier in life.

"I have trouble remembering names and the most frustrating is when they are names of people I know really well, I just can't bring the name to the surface," Sabin says.

"I felt I needed to do this because with my family history," Sabin says. "I felt studies I was participating in would help other people so that they won't have to go through what I did with my own relatives."

For more information, please visit:

Michigan Alzheimer's Disease Research Center (MADRC)

SOURCE University of Michigan Health System
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. New Report Shows Record Number of Medicines in Development to Treat Leading Causes of Cancer
2. New Analysis Estimates Numbers of Older U.S. Adults Who May Benefit From Statin Therapy
3. Stem Cell Treatment Leader Tiantan Puhua Adds Experienced International Medical Staff for Expanding Numbers of Patients
4. Retigabine Significantly Reduces the Number of Seizures in Adults With Inadequately Controlled Partial-Onset Epilepsy
5. PAREXEL Data Reveal A Record High Number of Clinical Trials Initiated
6. DaVita Clinical Research Completes Record Number of Renal Trials in 2007
7. Increases in West Nile Virus Replikin Concentrations Precede Increases in the Number of Human Cases
8. Nektar Terminates All Negotiations With Potential Partners for Inhaled Insulin; Increased Number of Lung Cancer Cases Observed in Ongoing Clinical Studies of Inhaled Insulin Patients
9. Test for Life Campaign Screens Record Number of DC Residents for HIV/AIDS
10. Recent Findings from the Framingham Offspring Study Show Low Numbers of LDL Particles (LDL-P) by NMR are Associated With Fewer Heart Disease Related Events than Equivalently Low Levels of LDL Cholesterol (LDL-C).(1)
11. AHF Seeks White House Clarification After Press Room Flap Over CDCs HIV Numbers
Post Your Comments:
(Date:10/9/2015)... , October 9, 2015 ... die sich einer Kolonoskopie im Rahmen eines ... unterziehen. Die NOCT-Studie bewertete auch die Compliance, ... --> ® ) an erwachsenen Patienten ... eines Screenings, einer beobachtenden oder einer diagnostischen ...
(Date:10/9/2015)... , October 9, 2015 ... (OTCQB: CNBX) has announced its execution of an Intellectual Property ... Liabilities Agreement with Cannabics, Inc. a Delaware Corporation, related party, ... --> --> These ... of the Company, whereby the Research and Development components ...
(Date:10/9/2015)... India , October 9, 2015 ... --> The report ... market and overall status of the ... of guidance and direction for companies ... . ...
Breaking Medicine Technology:
... PRO-DEX, INC. (Nasdaq: PDEX ) invites investors and ... fiscal 2012 first quarter financial results. (Logo:   ... be broadcast live over the internet on Wednesday, November 9, ... and may be accessed by visiting the Company,s website at ...
... VIEW, Calif., Nov. 3, 2011 VIVUS, Inc. (NASDAQ: ... were published in Obesity, the peer-reviewed journal of The ... the investigational drug Qnexa in 1,267 severely obese (BMI >/= 35 ... addition to average weight loss of 14.4% of initial body weight ...
Cached Medicine Technology:
(Date:10/9/2015)... ... October 09, 2015 , ... Each ... internships at the pre-eminent organization in global health: the World Health Organization (WHO). ... health disparities. These internships are a mechanism for WHO to help build public ...
(Date:10/9/2015)... ... October 09, 2015 , ... "My spouse and I rely on ... leaned against something," said an inventor from Buffalo, N.Y. "This is not only frustrating ... , The CANE REST enables a user to keep a cane upright while it’s ...
(Date:10/9/2015)... ... October 09, 2015 , ... Head Over Heels Athletic Arts ... developmental camp at the Karolyi Ranch in Huntsville, Texas on October 17-21. , ... Heels girls team head coach and executive director, said. “It's a stepping stone into ...
(Date:10/9/2015)... ... October 09, 2015 , ... Confidence Plus Insurance has ... community improvement initiative that involves working with a series of local charities throughout ... Confidence Plus Insurance is the Gleason Park Electric Violin Ensemble (GPEVE). , GPEVE ...
(Date:10/9/2015)... ... October 09, 2015 , ... ... of Innovations with Ed Begley Jr., airing 1st QT 2016 via the Discovery ... audiences on MMJ Phytotech Limited (MMJ) – a global leader in the field ...
Breaking Medicine News(10 mins):
... aiding certain patients with the blood cancer , , WEDNESDAY, ... of the once-banned drug thalidomide for patients with myeloma ... as it is to science: Don,t judge results too ... therapy regimens increased the odds of a complete remission, ...
... Counseling for All Combat Veterans, WASHINGTON, July 9 ... in 39 additional,communities across the country where the Department ... 2009., "Community-based Vet Centers -- already in all ... health program," said Dr. James B. Peake,Secretary of Veterans ...
... conditions cause significant decrease in body,s ability to repair ... News) -- Diabetes and being over- or underweight can ... the conclusion of two reports to be presented July ... of Human Reproduction & Embryology, in Barcelona, Spain. , ...
... Inc.,(NYSE and SWX: ZMH) announced today its second quarter ... over the Internet on,Thursday, July 24, 2008, at 8:00 ... will be made available at 7:00 a.m. the,morning of ... be accessed via Zimmer,s Investor Relations,website at ...
... the elderly and people without health insurance especially vulnerable, ... Every summer, an estimated 6,200 Americans are hospitalized for ... who were hospitalized died, according to the latest ... Healthcare Research and Quality. , Severe heat exposure, ...
... neighborhoods to advance benefits of selecting Michigan ... July 9 The Associated Food &,Petroleum Dealers (AFPD) ... to make fresh, local produce more readily,available to Metro ... program called "Buy Local, Eat Fresh.", "We have ...
Cached Medicine News:
... effective technology in anesthesia., ,Whether you ... ventilation, the operating theater or as a ... monitoring, the Aliseo product family allows you ... ,With three product models, you have the ...
... performance and value., ,The Aestiva/5 7100 ... the Aestiva/5 anesthesia system (open architecture, integrated ... newest anesthesia ventilation platform - the 7100 ... engineered to allow for ventilation of a ...
... ,The Aestiva/5 offers exceptional capabilities and flexibility, ... therapy., ,The Aestiva/5 with SmartVent offers ... ventilator, saving you the cost of bringing ... Its flexible ergonomic design and intuitive operations ...
... to quality patient care., ,S/5 Anesthesia ... to anesthesia delivery. As part of the ... features, electronically controlled gas delivery and agent ... to create a truly integrated system. The ...
Medicine Products: