Navigation Links
Nplate(R) Data From MDS Studies Presented at ASH
Date:12/6/2009

NEW ORLEANS, Dec. 6 /PRNewswire-FirstCall/ -- Amgen Inc. (Nasdaq: AMGN) today announced results from three studies on the safety and efficacy of Nplate® (romiplostim) in adult patients with myelodysplastic syndromes (MDS). MDS is a pre-leukemic condition in which early blood forming cells in the bone marrow are unable to mature normally, thereby limiting their ability to produce normal mature blood elements, which can lead to low platelet counts. The results of the studies were presented at the 2009 American Society of Hematology (ASH) Annual Meeting and Exposition (ASH Abstracts #1769, #1770 and #2765).

Interim Results from Long-Term Open-Label Extension Study of Nplate in MDS (Abstract #2765)

The ongoing, open-label extension study was designed to evaluate the safety and efficacy of Nplate in lower risk MDS patients. The primary endpoints of the interim study for presentation at ASH evaluated adverse event rates with long-term use of Nplate and incidence of antibody development to Nplate and/or thrombopoietin (TPO). Secondary endpoints evaluated the incidence of bleeding events and platelet response during the study period.

Nplate was generally well-tolerated, with the majority of patients (n=28) achieving a platelet response (61 percent) for eight or more consecutive weeks. The primary endpoint evaluating adverse event rates was met, with most patients experiencing adverse events that were mild to moderate with the most common being epistaxis (36 percent), arthralgia (29 percent), anemia (21 percent) and cough (21 percent). The co-primary endpoint was also met, as no neutralizing antibodies to Nplate or TPO were observed, nor progression to acute myeloid leukemia (AML). In addition, no cases of bone marrow fibrosis were reported.

Results for the secondary endpoint showed that 64 perc
'/>"/>

SOURCE Amgen Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
2. Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies
3. Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update
4. Boston Scientifics Urology/Gynecology Products Featured in Studies at Global Congress
5. Additional Data from the Qnexa Phase 3 Studies Presented at The Obesity Society 27th Annual Scientific Meeting
6. Reportlinker Adds Driving Successful Pharma Brands: Case Studies of Real Product Launches
7. Reportlinker Adds Outsourcing Preclinical Studies to China
8. New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery
9. New Clinical Studies Demonstrate the Accuracy of Masimo Noninvasive and Continuous Hemoglobin Monitoring Technology
10. AFFiRiS AG - Encouraging Results From Phase I Studies of two Alzheimers Candidate Vaccines Trigger a EUR 10 Million Milestone Payment
11. PEAK Surgical Announces Results of First PRECISE Studies at American College of Surgeons Clinical Congress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... WAYNE, N.J. , Dec. 19, 2014  In the Friday, ... , a 16-page supplement dedicated to Healthcare Information Technology (HIT) features ... innovation in Healthcare IT in partnership with several leading healthcare organizations. ... be distributed across several major metropolitan markets, such as ... Washington DC / Baltimore , Minneapolis ...
(Date:12/19/2014)... LONDON , December 19, 2014 ... authentication services in the World announced the appointment of ... Anthony R. Vonsée, as Chief Channels and Partner Officer. ... Datanomic since 2004 through to its acquisition by Oracle ... Development Director at Geneva and ...
(Date:12/19/2014)... , Dec. 19, 2014  Newport Corporation ... Siddhartha Kadia, Ph.D. has joined the company,s Board ... Executive Officer and a director of Evans Analytical ... testing, evaluation and analytical services to companies in ... Prior to joining Evans Analytical Group, Dr. Kadia ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2
... ANF Group, Inc ., a South Florida based ... 170,000-square-foot Joe DiMaggio Children,s Hospital – the first free ... (Photo: http://photos.prnewswire.com/prnh/20110614/FL18288 ) The hospital,s ... designed to earn Gold Leadership in Energy and Environment ...
... June 14, 2011 CVS/pharmacy provides ... at more than 7,200 convenient locations nationwide. Shoppers have come ... larger-than-ever selection of gifts, goods and everyday needs. From popular ... the hottest gear and thoughtful keepsakes perfect for every dad, ...
Cached Medicine Technology:ANF Group, Inc. Completes New Joe DiMaggio Children's Hospital 2Find the Best in Gadgets, Grilling and Grooming in Just One Stop This Father's Day at CVS/pharmacy 2Find the Best in Gadgets, Grilling and Grooming in Just One Stop This Father's Day at CVS/pharmacy 3
(Date:12/21/2014)... 21, 2014 The number of Mirena ... consolidated litigation underway in New Jersey, Bernstein Liebhard LLP ... 1,375 claims involving the birth control IUD have now ... were filed by women who allege spontaneous migration of ... uterine perforations and other complications they were inadequately warned ...
(Date:12/21/2014)... Tiburon, CA (PRWEB) December 21, 2014 ... and resolved performance issues in hundreds of emergency departments ... patient satisfaction. Its findings have been translated into an ... hospital leaders to correct deficiencies and enhance the patient ... of outsourced emergency physician staffing and management services for ...
(Date:12/21/2014)... (PRWEB) December 21, 2014 CannabisClassifieds.com celebrates marijuana’s ... The only one of its kind, the site has ... local marijuana for 14 years running. It uniquely combines ... to make cannabis readily available to the masses. Assuring ... grasping the golden ring of public approval. , ...
(Date:12/20/2014)... December 21, 2014 BambooIndustry.com is ... Recently, the business has announced its bamboo flooring ... the best material from certified suppliers, and offers ... customers worldwide. In the current promotion, all customers ... off, when they say they know BambooIndustry.com from ...
(Date:12/20/2014)... 20, 2014 Dress company LunaDress has recently ... announced its Christmas Sale, offering big discounts on all of ... has an idea to own a perfect wedding gown. If ... wedding dress, then come to LunaDress. Many different wedding dress ... Visit our website now and enjoy the current special offer, ...
Breaking Medicine News(10 mins):Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 2Health News:Mirena Lawsuits Approach 1,400 in Bergen County Litigation, Bernstein Liebhard LLP Reports 3Health News:NES Health Launches Stipend Program for Emergency Physicians in Training to Financially Assist Emergency Department Doctors While They Learn 2Health News:CannabisClassifieds.com Maintains its “Craigslist for Cannabis” Standing with Website Re-launch 2Health News:Eco-friendy Bamboo Flooring Manufacturer BambooIndustry.com Introduces Its Bamboo Flooring Promotion for 2015 2Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2
... Tenn., July 2 NavigatorMD, Inc., a ... analytics in support of Value-Based Plan Design ... as Director, Business Development and,Sales., Norris ... related insurance,and technology, including market development and ...
... Combination Creates New Opportunities for Expansion of HIFU ... LLC (USHIFU), the,distributor and provider of non-invasive high ... it has completed the acquisition,of Focus Surgery, Inc. ... the Sonablate(R) 500, an image-guided acoustic ablation,device. This ...
... uncovers a genetic mutation that improves response to therapy ... drug that inhibits tumor blood vessel formation slows the ... international study finds. , Of the 93 patients with ... treatment with motesanib diphosphate. Of those 49 patients, 14 ...
... -- Compact, bedside brain-activity monitors detected most seizures ... of Medicine in St. Louis showed. That means ... for electrical seizures until confirmation with conventional EEG ... in the June issue of Pediatrics . ...
... & CEO, American Association of,Homes and Services for ... Therapy,Caps Exceptions Process, WASHINGTON, July 2 ... CEO, American Association of Homes and,Services for the ... Caps,Exceptions Process:, "Medicare beneficiaries are once again ...
... that its President and Chief Executive Officer Sean ... Year(R) 2008 Award in the,Applied Science category in ... region. This award recognizes outstanding entrepreneurs who,are building ... an independent panel of judges and the award ...
Cached Medicine News:Health News:Marshall Norris Joins NavigatorMD as Director of Business Development and Sales 2Health News:USHIFU, LLC Completes Acquisition of Focus Surgery, Inc. 2Health News:New Drug Slows Thyroid Cancer 2Health News:Seizures in newborns can be detected with small, portable brain activity monitors 2Health News:Seizures in newborns can be detected with small, portable brain activity monitors 3Health News:AAHSA Statement: Therapy Caps Ration Care 2Health News:Precision Therapeutics President and CEO Sean McDonald Named Ernst & Young Entrepreneur of the Year(R) 2008 Regional Award Winner 2
FF 450plus IRu Fundus camera with Visupac / System 431. Digital results in all capture modes and unlimited Visupac software....
The most advanced retinal cameras for fluorescein, color and ICG angiography with full digital imaging capability....
All welded construction for strength and durability. Choice of stainless steel or chrome plated models....
All welded construction for strength and durability. Choice of stainless steel or chrome plated models....
Medicine Products: