Navigation Links
Nplate(R) Data From MDS Studies Presented at ASH
Date:12/6/2009

NEW ORLEANS, Dec. 6 /PRNewswire-FirstCall/ -- Amgen Inc. (Nasdaq: AMGN) today announced results from three studies on the safety and efficacy of Nplate® (romiplostim) in adult patients with myelodysplastic syndromes (MDS). MDS is a pre-leukemic condition in which early blood forming cells in the bone marrow are unable to mature normally, thereby limiting their ability to produce normal mature blood elements, which can lead to low platelet counts. The results of the studies were presented at the 2009 American Society of Hematology (ASH) Annual Meeting and Exposition (ASH Abstracts #1769, #1770 and #2765).

Interim Results from Long-Term Open-Label Extension Study of Nplate in MDS (Abstract #2765)

The ongoing, open-label extension study was designed to evaluate the safety and efficacy of Nplate in lower risk MDS patients. The primary endpoints of the interim study for presentation at ASH evaluated adverse event rates with long-term use of Nplate and incidence of antibody development to Nplate and/or thrombopoietin (TPO). Secondary endpoints evaluated the incidence of bleeding events and platelet response during the study period.

Nplate was generally well-tolerated, with the majority of patients (n=28) achieving a platelet response (61 percent) for eight or more consecutive weeks. The primary endpoint evaluating adverse event rates was met, with most patients experiencing adverse events that were mild to moderate with the most common being epistaxis (36 percent), arthralgia (29 percent), anemia (21 percent) and cough (21 percent). The co-primary endpoint was also met, as no neutralizing antibodies to Nplate or TPO were observed, nor progression to acute myeloid leukemia (AML). In addition, no cases of bone marrow fibrosis were reported.

Results for the secondary endpoint showed that 64 perc
'/>"/>

SOURCE Amgen Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Nplate(R) Approved in the European Union for the Treatment of Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
2. Reportlinker Adds Direct to Consumer (DTC) Advertising in Pharmaceuticals - Current and Future Market Outlook, Regulatory Landscape and Case Studies
3. Wound Management Technologies (OTCBB: WNDM) Reports Revenue Increase of 33.5%; Posts Evidence-Based Studies for CellerateRx; and Business Update
4. Boston Scientifics Urology/Gynecology Products Featured in Studies at Global Congress
5. Additional Data from the Qnexa Phase 3 Studies Presented at The Obesity Society 27th Annual Scientific Meeting
6. Reportlinker Adds Driving Successful Pharma Brands: Case Studies of Real Product Launches
7. Reportlinker Adds Outsourcing Preclinical Studies to China
8. New Studies Demonstrate Benefits of Minimally Invasive Hysterectomy and Colectomy When Compared to Open Surgery
9. New Clinical Studies Demonstrate the Accuracy of Masimo Noninvasive and Continuous Hemoglobin Monitoring Technology
10. AFFiRiS AG - Encouraging Results From Phase I Studies of two Alzheimers Candidate Vaccines Trigger a EUR 10 Million Milestone Payment
11. PEAK Surgical Announces Results of First PRECISE Studies at American College of Surgeons Clinical Congress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... July 1, 2015 Rock Creek Pharmaceuticals, Inc., ... on chronic inflammatory disease and neurologic disorders, announced today ... with anatabine citrate, the Company,s lead compound. Results from ... anatabine citrate can significantly inhibit the activation of inflammatory ... is developing this compound in a Phase 1 clinical ...
(Date:7/1/2015)... SAN FRANCISCO , July 1, 2015 ... a new study Stationary Oxygen Concentrators Market ... markets are poised to achieve continuing growth as the ... develop COPD and other respiratory conditions where oxygen is ... a dramatic manner. Portable devices have become affordable and ...
(Date:7/1/2015)... DIEGO , July 1, 2015 OncoSec Medical ... intratumoral cancer immunotherapies, today announced that CEO and President ... celebration of the Company,s listing to The Nasdaq Stock Market ... Nasdaq MarketSite in New York City . ... employees, investors, and stakeholders, we are honored to open the ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 2Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 3Rock Creek Pharmaceuticals Reports Human Proof of Principle Study of Lead Compound Demonstrating Inhibition of Inflammatory Markers In White Blood Cells 4Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 3Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 4OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 2OncoSec Medical to Ring The Nasdaq Stock Market Opening Bell 3
... releases of Elekta,s XiO® treatment planning system and Focal ... and deliver radiation therapy plans more efficiently. ... Therapy (IMRT) segmentation algorithm, fluence map smoothing and DICOM ... for contouring, enabling clinicians to contour anatomy faster and ...
... the vaccines division of Sanofi (EURONEXT: SAN and NYSE: ... 2011-2012 Fluzone® Influenza Virus Vaccine in the U.S. This shipment ... influenza vaccine the company plans to deliver to the U.S. ... producer of influenza vaccine in the U.S., supplying more than ...
Cached Medicine Technology:Latest Releases of Elekta's XiO Planning and Focal Contouring Systems Designed to Increase Efficiency in Planning Therapy for Patients with Cancer 2Sanofi Pasteur Starts Shipping Influenza Vaccine for the 2011-2012 Season 2Sanofi Pasteur Starts Shipping Influenza Vaccine for the 2011-2012 Season 3Sanofi Pasteur Starts Shipping Influenza Vaccine for the 2011-2012 Season 4Sanofi Pasteur Starts Shipping Influenza Vaccine for the 2011-2012 Season 5Sanofi Pasteur Starts Shipping Influenza Vaccine for the 2011-2012 Season 6
(Date:7/1/2015)... ... ... Renowned rhinoplasty surgeon and Symposium Chairman, Dr. Rod J. ... Set for March 6th - 8th, the 2016 meeting will be held at the ... fundamentals of nasal surgery through the most modern advancements and updates in rhinoplasty and ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... Did you ... June is Men’s Health Month, and we at Advanced Fertility Center of Texas (AFCT) ... in men. , While infertility is often considered to be a “woman’s issue,” ...
(Date:7/1/2015)... , ... July 01, 2015 , ... Convoy of ... community celebration in the Twin Cities on Saturday, August 1, at Spring Lake Park ... community will provide more than $1 million worth of goods and services including free ...
(Date:7/1/2015)... ... ... Scoliosis is a disorder in which the normally straight vertical line of the spine curves ... of the population, or an estimated 6 to 9 million people. While it is found ... 10 and 15. Most types of scoliosis are more common in girls than in boys. ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... compensation law has just published a top ten list they hope will guide ... Click here to read it now. , More than 450 ...
Breaking Medicine News(10 mins):Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 2Health News:Dr. Rod J. Rohrich Announces Dates for 2016 Dallas Rhinoplasty Symposium 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 2Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 3Health News:Male Fertility: Improve Testosterone and Fertility With Natural Approaches 4Health News:Convoy of Hope Hosts Community Event in the Twin Cities 2Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 2Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 3Health News:Scoliosis: A Guide for Parents from Orthopedic Surgeon Dr. Fabien Bitan 4Health News:New Report Identifies Top 10 Mesothelioma Research Priorities, According to Surviving Mesothelioma 2
... , TUESDAY, Nov. 22 (HealthDay News) -- The U.S. Justice ... $950 million to resolve investigations into its marketing of the ... 2004 after studies revealed the drug increased users, risks of ... million in criminal fines and $628.4 million as a civil ...
... that improvements are possible," says Hyland at the University of ... 234 million major surgical procedures are conducted worldwide each year. ... a major surgical procedure each year. Although surgery saves ... WHO, serious complications occur in three to 17 per cent ...
... and epilepsy could also prevent heart attacks, according to researchers ... who have been using it to stimulate the body,s own ... caused by the formation of a blood clot in one ... and nutrients. The clot reduces the supply of oxygen, which ...
... malignant form of brain tumor. In many cases, neurosurgeons are ... risk of destroying too much brain tissue in the process. ... extensions by which the tumor spreads into surrounding healthy tissue. ... that have remained in the head, almost all glioblastoma patients ...
... , TUESDAY, Nov. 22 (HealthDay News) -- ,Taking slightly ... the brand name Tylenol) over time can lead to an ... a new study. These "staggered overdoses" can occur when ... acetaminophen than they should, explained Dr. Kenneth Simpson, author of ...
... Elderly black patients who require surgery for an intestinal condition ... hospital than white patients, a new study has found. ... patients had the same health insurance as white patients, the ... in the lining of the intestine become infected or inflamed. ...
Cached Medicine News:Health News:Merck to Pay $950M to Settle Probe of Vioxx Marketing 2Health News:Merck to Pay $950M to Settle Probe of Vioxx Marketing 3Health News:Creating safer surgery to save more lives 2Health News:Creating safer surgery to save more lives 3Health News:Substance in cancer medicine could prevent heart attacks 2Health News:Enhanced treatment of brain tumors 2Health News:Too Much Acetaminophen Over Time May Damage Liver 2Health News:More Blacks Die in Hospital After Diverticulitis Surgery 2
... Cardiac troponin I (cTnI) has been useful ... to Emergency Departments (ED) with chest pain. ... diagnosed when blood levels of sensitive and ... MB isoenzyme of creatine kinase (CK-MB), and ...
... Aio! 2nd generation cardiac troponin ... sensitive immunoassay providing quantitative results ... less than 18 minutes. The ... unique combination of antibodies that ...
... high-throughput immunoassay system built around the many ... the important addition of Logic Driven Incubation ... designed for optimal performance with the fastest ... assays such as the cardiac biomarkers and ...
The Acute Care myoglobin method is an in vitro diagnostic test for the measurement of myoglobin in heparinized whole blood /plasma. Myoglobin measurements can be used as an aid in diagnosing myocardi...
Medicine Products: