Navigation Links
Novo Nordisk New Data From a Phase 3 Study Confirms Clinical Benefits of Once-Daily Liraglutide in the Management of Type 2 Diabetes
Date:9/8/2008

Paradoxically, many of the common treatment regimens for type 2 diabetes actually cause weight gain.

Treatment with liraglutide in LEAD(TM) 4 also led to a statistically significant decrease in blood pressure as seen in three of the other LEAD(TM) studies: reductions of 6.71 mmHg and 5.65 mmHg with liraglutide 1.2 mg and 1.8 mg, respectively, were observed compared to a decrease of 1.11 mmHg in the comparator group.

Beta cell function, as assessed by multiple parameters (HOMA, C-peptide and proinsulin to insulin ratio), was also significantly improved in subjects who received liraglutide versus the comparator group. Beta cell function is an important measure of disease progression in type 2 diabetes.

LEAD(TM) 4 is the last of the five phase 3a LEAD(TM) (Liraglutide Effect and Action in Diabetes) studies to be presented.

"The complete LEAD(TM) clinical trials program provides convincing evidence that liraglutide represents an effective new treatment approach for type 2 diabetes," said Dr. Bernard Zinman, Professor of Medicine, University of Toronto and Director of the Diabetes Centre Mount Sinai Hospital, Toronto, Canada. "In this clinical trial program, liraglutide offers effective glucose lowering as monotherapy or as an add on to other oral antidiabetic therapies while also consistently lowering weight and blood pressure and enhancing beta-cell function."

About the study

The LEAD(TM) 4 study was a 26-week randomized trial that compared the efficacy and safety of two different doses of liraglutide (1.2 mg and 1.8 mg, QD) to placebo, all added to metformin 2 g (1 g, BID) and rosiglitazone 8 mg (4 mg, BID). The trial included 533 subjects with a mean age of 55.1 years, mean body mass index of 33.5 kg/m2, and mean HbA1c of 8.3. All subjects were previously treated with one or more OADs and received run-in rosiglitazone and metformin therapy before being randomized to liraglutide or placebo.


'/>"/>

SOURCE Novo Nordisk
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Insulin Analogues From Novo Nordisk, Eli Lilly and Sanofi-Aventis Will Drive Growth in the Type 1 Diabetes Drug Market
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
4. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
5. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
6. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
7. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
8. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
9. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
10. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
11. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... , Sept. 22, 2014 Auxilium ... specialty biopharmaceutical company, today announced that its Board ... non-binding and conditional proposal from Endo International plc ... and legal advisors, has unanimously determined it is ... its existing merger agreement with QLT Inc. ("QLT") ...
(Date:9/20/2014)... /CNW/ - The issue: Mylan Pharmaceuticals ULC Canada, in consultation ... Mylan-Nitro Spray 0.4 mg/metered dose due to the product missing ... A missing "dip tube" could pose a ... This defect may lead patients to believe they are receiving ... it. Not receiving nitroglycerin could place them at risk for ...
(Date:9/19/2014)... 19, 2014 A pharmaceutical executive in the ... three issues he wanted the research and consulting firm ... personnel (especially for secondary research) to maximize efficiency and ... increased workload , Automation of market research processes ... , How to implement and manage those automated systems ...
Breaking Medicine Technology:Auxilium Provides Transaction Update 2Auxilium Provides Transaction Update 3Auxilium Provides Transaction Update 4Auxilium Provides Transaction Update 5Auxilium Provides Transaction Update 6Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2
... The complex cases performed,during this month,s ... Das, an interventional cardiologist at Presbyterian,Hospital of ... vascular,disease, a looming health concern as the ... heart disease. The country,s obesity epidemic will ...
... Calif., Oct. 26 Accuray,Incorporated (Nasdaq: ARAY ... radiosurgery,announced today that the company is partnering with ... in Houston, Texas to launch a prospective,clinical study ... Patients in the study will be randomly assigned ...
Cached Medicine Technology:Cardiologists Tackle 'Next Frontier' in Cardiovascular Disease 2M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 2M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 3M. D. Anderson Cancer Center to Lead Study of Surgery vs. CyberKnife(R) Radiosurgery for Operable Lung Cancer Patients 4
(Date:9/22/2014)... Pain does not need to rule your life ... reader-friendly book designed to guide the individual who suffers with ... book is written to help the reader who is struggling ... regain a pain-free life — a daily “go-to” guide on ... pain has become an epidemic, with over 100 million Americans ...
(Date:9/22/2014)... YORK (September 22, 2014) Montefiore Medical Center, Albert Einstein ... Women,s Hospital have received a $300,000 grant from The ... the impact of health Information Technology (IT) on patient ... electronic orders, an important clinical patient safety issue impacted ... will be the first time IT leaders have data ...
(Date:9/22/2014)... of flavonoid found in hops and beer, has been ... in young mice, but not in older animals. , ... Research by scientists from the Linus Pauling Institute ... It,s another step toward understanding, and ultimately reducing the ... mammalian species, including humans. , Flavonoids are compounds found ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Medical ... for a three-day conference to discuss brain-related diseases ... injury from concussions and neurodegenerative disorders. , ... director affiliated with a Silverado memory care community ... dedicated expertise in memory care, hosts the annual ...
(Date:9/22/2014)... North Carolina at Chapel Hill researchers represents an important ... are experiencing the earliest stages of psychosis. , Psychosis ... severe mental disorders such as schizophrenia. Schizophrenia emerges in ... in every 100 people. In severe cases, the impact ... and the burden on family members can be almost ...
Breaking Medicine News(10 mins):Health News:Naturopathic Doctor Inspires and Guides Those Who Suffer with Chronic Pain, Pointing the Way Back to Pain-free Living 2Health News:AHRQ grant awarded to study the impact of health IT on patient safety at Montefiore and Einstein and Brigham and Women's Hospital 2Health News:Compound from hops aids cognitive function in young animals 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 2Health News:Nation’s Leading Brain Health Experts Gather for Annual Silverado Medical Director Conference 3Health News:Blood test may help determine who is at risk for psychosis 2
... -CTA Acceptance in the Netherlands Triggers Milestone Payment ... Radius Health ("Radius"),announced today that the Dutch regulatory ... RAD1901, Radius, novel,tissue-selective SERM (selective estrogen receptor modulator) ... to begin a Phase I,clinical trial of RAD1901 ...
... Thanks to Nutrition on the Go, an,innovative new program ... more than 1,700 restaurants nationwide is available in,a flash through ... and menu item., Not cell phone savvy? No worries. ... menu item you need help with, then send that info ...
... LANCASTER, Pa., Jan. 30 Members of Highmark,s,FreedomBlue ... care options. Effective immediately, both routine and emergency,medical ... and Lancaster,Regional hospitals., "We,re pleased to partner ... and high-quality health care to people with Medicare ...
... CHESTER, N.J. and SLOUGH, England, Jan. 30 ... the,successful completion of its acquisition of Adams Respiratory ... cash tender offer followed by a,short- form merger ... and into Adams. As a result of this ...
... (OTC Bulletin,Board: NTRZ) announced today that it has filed ... U.S. Securities and Exchange,Commission (SEC). If and when declared ... offer and sell under the universal shelf registration,statement up ... preferred,stock, depositary shares and/or warrants to purchase any of ...
... Jan. 30 EMH Regional Healthcare System has,selected ... increasing bad debt and streamline administration of its ... is a 434-bed, non-profit hospital,system with campuses in ... the,EMH Regional Healthcare System has served the needs ...
Cached Medicine News:Health News:Radius Announces Launch of RAD1901 Clinical Program for the Treatment of Hot Flashes 2Health News:Radius Announces Launch of RAD1901 Clinical Program for the Treatment of Hot Flashes 3Health News:Ring Up Instant Nutrition Info via Text Message to DIET1 (34381) 2Health News:Heart of Lancaster and Lancaster Regional Join Highmark Blue Shield Medicare Advantage Network 2Health News:Reckitt Benckiser Completes Acquisition of Adams Respiratory Therapeutics, Inc. 2Health News:NutraCea Files Universal Shelf Registration Statement 2Health News:EMH Regional Medical Center Selects TransUnion's Healthcare Revenue Cycle Platform to Help Reduce Its Bad Debt 2Health News:EMH Regional Medical Center Selects TransUnion's Healthcare Revenue Cycle Platform to Help Reduce Its Bad Debt 3
... 150 watt halogen light ... , ,SOLOS Endoscopy shares ... patient with the highest quality ... research and development of advanced ...
... first for Linvatec! The EnVision Autoclavable ... and proprietary technology to ensure true ... Shockflex prism system gives our customers ... their investment. With an integrated multi-specialty ...
... surgery is founded on superior medical video ... 3-Chip cameras, 1-Chip cameras, Light sources, Couplers ... demanding needs., ,Superior resolution and color ... 3-Chip cameras, and are the benchmark by ...
... System provides easy-to-use features, auto iris, white ... camera head construction is based on Solos ... 1-Chip Camera System, Domestic (GS 9960-NTSC) includes: ... with power cord and video cables , ...
Medicine Products: