Novexel currently has two novel antibacterials in Phase II clinical development. These are the injectable beta-lactamase inhibitor, NXL104 and the oral streptogramin antibiotic, NXL103. NXL104 is being developed in combination with the cephalosporin antibiotic ceftazidime (CAZ-104) and is currently in two Phase II clinical trials in patients with complicated intra-abdominal infections (cIAIs) and patients with complicated urinary tract infections (cUTIs). Under an agreement concluded in January 2008, Novexel granted Forest Laboratories ( FRX) the rights to develop NXL104 in combination with ceftaroline (CEF-104) solely in North America.
NXL103 is currently in a Phase II clinical trial in adults with acute bacterial skin and skin structure infections (ABSSSI). NXL103 has previously delivered positive Phase II results in a trial evaluating it in the treatment of community acquired pneumonia (CAP).
In addition, Novexel has two further programmes in preclinical development, NXL105, a novel anti-Pseudomonal antibiotic and NXL201, a novel echinocandin antifungal agent.
Novexel was created in December 2004 as an independent spin-out of the sanofi-aventis (Euronext Paris: SAN, SNY) anti-infectives unit. Novexel has a team of 54 employees with significant experience in anti-infective research and development, who are located in Paris, France and Philadelphia, USA.
Novexel's investors are Sofinnova, Atlas Venture, Novo A/S, Abingworth, Edmond de Rothschild Investment Partners, Goldman Sachs, NeoMed and Daiwa SMBC Capital Co., Ltd.
 Source: IMS Health, MIDAS, 2006-2008 For further information please contact: Novexel Gordon Waldron, CFO firstname.lastname@example.org Citigate Dewe Rogerson David Dible/Amber Bielecka/Nina Enegren Tel.: +44-(0)207-638-95-71 '/>"/>
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