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Novexel to Present Four Posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases in Helsinki
Date:5/17/2009

PARIS, May 18 /PRNewswire/ -- Novexel, a speciality pharmaceutical company focused on the discovery and development of novel antibiotics designed to overcome the significant global problem of microbial resistance, announces that its two most advanced pipeline products NXL104 and NXL103 are the subject of four posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). The ECCMID conference is taking place in Helsinki between 16th and 19th May 2009.

NXL104, Novexel's broad spectrum class A and C beta-lactamase inhibitor, is the subject of one poster. Novexel is currently conducting two Phase II clinical trials in patients with complicated urinary tract infections and complicated intra-abdominal infections with NXL104 in combination with ceftazidime. The poster provides in vitro data showing that a ceftazidime/NXL104 combination is rapidly bactericidal against a range of beta-lactamase-producing strains of Enterobacteriaceae, including E. coli, and Klebsiella. Data presented also showed that one of the most important factors affecting the pharmacodynamics of the combination is maintaining a critical concentration of the inhibitor (NXL104) to suppress beta-lactamase activity. (Poster P 1463).

NXL103, a novel oral streptogramin antibiotic, is the subject of three posters at the ECCMID conference. Novexel has recently completed a successful Phase II study with NXL103 in patients with community acquired pneumonia. The first of the three posters provides in vitro data showing that NXL103 was active against methicillin resistant Staphylococcus aureus (MRSA) and organisms responsible for lower respiratory tract infections, including Streptococcus pneumoniae and Haemophilus influenzae , (Poster P 1393). The second poster contains in vivo data demonstrating that, following oral administration, NXL103 was able to kill intracellular drug-resistant and non-drug-resistant strains o
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