Navigation Links
NovelMed Awarded NIH Fast Track SBIR Grant for $1.43 Million to Advance Development of its Anti-Complement Antibody for Orphan Disease
Date:9/9/2013

CLEVELAND, Sept. 9, 2013 /PRNewswire-USNewswire/ -- NovelMed Therapeutics (www.novelmed.com) announced the receipt of a combined $1.43 million SBIR Grant from the NIH. The first installment of the award (for $542,572) will be used to evaluate NovelMed's lead candidate's therapeutic superiority for treating Paroxysmal Nocturnal Hemoglobinuria (PNH).  Subsequent funding, to be released on demonstration of superiority, will be used for later stage development.  The NIH award represents a major step toward commercialization of the Company's orphan disease therapy platform.

(Logo: http://photos.prnewswire.com/prnh/20130909/DC73243LOGO )

The grant follows strong evidence from recent studies that its lead candidate will block intra- and extra-vascular hemolysis, both of which must be controlled in order to gain advantages over eculizumab. These studies indicate that NovelMed's lead candidate could have a superior efficacy, safety and dosage profile relative to eculizumab.  The project will compare the two therapies under various experimental conditions.

"As a small business we applaud the support of the NIH in transitioning promising technologies from the laboratory to the clinic. We are honored that the scientific peer-review process at the NIH has repeatedly deemed our developmental concepts worthy of continued support as we advance the development of life-changing products," stated Rekha Bansal, Ph.D., Founder and Chief Executive Officer of NovelMed.

About PNH

PNH is a rare and life-threatening blood disorder where the immune system attacks red blood cells resulting in significant disease outcomes including red blood cell destruction and long-term anemia. Current treatment options are limited and only control cell destruction via the intravascular pathway. Despite staggering success of the current complement inhibitor being marketed, some patients continue to remain anemic due to the second newly-discovered pathway for red blood cell destruction also known as "extravascular hemolysis". NovelMed's leading drug candidate prevents red blood cell destruction via both pathways and therefore is expected to provide significant benefit in the total control of anemia.

About NovelMed

NovelMed Therapeutics, Inc., a privately-held biotech located in Cleveland, Ohio, is developing transformative treatments for orphan and non-orphan disease conditions.  The company has developed a portfolio of antibodies targeted for the treatments of complement-mediated inflammatory and hemolytic disorders including paroxysmal nocturnal Hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), age-related macular degeneration (Dry & Wet AMD), arthritis (RA & OA), and cardiovascular diseases.  NovelMed's drug candidates are differentiated by their unique mechanism(s) of action that are expected to deliver therapies with superior efficacy, safety and dosage profiles. The company is currently looking for strategic partners for clinical trials and commercialization of its therapeutic drugs.

Similar drug discovery is being pursued by a few companies including Roche/Genentech and Novartis, which are both pursuing AMD therapies, and Alexion which is currently marketing Soliris (eculizumab), an FDA approved antibody-based therapy.

Disclaimer

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Research reported in this press release was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number R44HL115909.  


'/>"/>
SOURCE NovelMed
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Pharmaceutical Industry Service Company Awarded The UKs Most Prestigious Business Accolade in Recognition of Outstanding Achievement in International Trade
2. QBC Diagnostics Awarded GSA Contract
3. Ampio Awarded US and Canadian Patents that will Bolster the Commercialization of Optina™ for the treatment of Diabetic Macular Edema (DME)
4. Northwest Bio Awarded $5.5 Million German Government Grant
5. Nonin Medical Awarded Novation Contract for Clinically Proven Pulse Oximeters
6. Elsevier / Gold Standards Kay Morgan Awarded NCPCP Highest Honor
7. Avaxia Biologics is Awarded U.S. Patent for Method to Treat Radiation Damage to the Digestive Tract and Mucositis Caused by Radiation
8. New Chronic Wound Therapy Awarded at Texas Largest Life Science Event
9. SurgiCount Medical Awarded Contract From HealthTrust Purchasing Group for the Safety-Sponge® System
10. Sorrento Therapeutics Awarded Third Phase I STTR Grant
11. Texas A&M System Awarded National Center for Innovation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... 2, 2016 Orthopedic Implants (Including Spinal ... Expected to Gain a Significant Market Share Owing to a ... ... According to a new report by ... Sterile Packaging: Clamshell Product Type Segment Projected to Witness a ...
(Date:12/2/2016)... On Thursday, the NASDAQ Composite and ... the Dow Jones Industrial Average managed to stay in green. ... which prompted Stock-callers this morning to look at the performances ... NUVA ), Smith & Nephew PLC (NYSE: SNN ... Cesca Therapeutics Inc. (NASDAQ: KOOL ). You can ...
(Date:12/2/2016)... 2016 The concept of rare diseases and the ... this sector has been taking shape in Europe ... aspects and initiatives related to orphan medicinal products have been ... of member states individually. Many member states in the EU ... of orphan medicinal products, the result of which took the ...
Breaking Medicine Technology:
(Date:12/2/2016)... ... , ... Yisrayl Hawkins, at The House of Yahweh in Abilene, Texas, has ... Prophecy. Yisrayl says this generation, known as the Last Generation, started in 1934 A.Y. ... line up exactly with Bible Prophecy – a protected way for those who will ...
(Date:12/2/2016)... ... December 02, 2016 , ... On November 24th, 2016, Thanksgiving ... eight different sites throughout Miami-Dade and Broward counties. This is the largest meal ... on Thanksgiving morning by putting together individual meals via assembly lines and passing ...
(Date:12/2/2016)... ... December 02, 2016 , ... ‘Tis the season for giving! Today, 20 ... the National Family Partnership and the Drug Enforcement Administration as part of the National ... the 10 winning schools who decorated their campuses with this year’s Red Ribbon Week ...
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the ... while brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that there ... this handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... mental health treatment has announced the opening of a new residential mental health ... girls with mental health issues such as severe anxiety, depression, bi-polar disorder, and ...
Breaking Medicine News(10 mins):