Navigation Links
Novel Xeloda(R) Dosing Schedule May Offer Well-Tolerated Alternative for Treatment of Advanced Breast Cancer
Date:4/18/2008

r parts of the body, has an especially poor prognosis, with a five-year survival rate of 27 percent. Currently, there are two and a half million breast cancer survivors in the United States. According to the ACS, breast cancer death rates are going down; the decline may be the result of early detection and treatment.

About the Study

Prior to study initiation, the Norton-Simon mathematical model (Norton et al, AACR 2005) -- which explores how the growth characteristics of a cancer affect response to chemotherapy -- was applied to determine that the maximum impact of Xeloda treatment in breast cancer patients occurs after seven days. Based on this finding, the single-center, open-label phase I/II trial was designed to determine the maximum tolerated dose (MTD) of Xeloda administered orally for seven days, followed by a seven-day rest (7-on/7-off), in patients with advanced-stage breast cancer. MTD was defined as the highest dose for which the incidence of dose-limiting toxicity (DLT) is less than 33 percent. DLT was defined as grade 3/4 hematologic toxicity lasting greater than two weeks despite growth factor support, or any grade 3/4 nonhematologic toxicity.

The Phase I study dose escalation scheme was a standard "3+3" design, using flat dosing that begins at 1,500 mg twice daily and increases by 500 mg/dose level until the MTD is reached. All patients in a cohort were observed for 28 days before enrollment to the next level is permitted to monitor for delayed toxicity.

The study showed that the dose dense regimen was well-tolerated in patients with advanced breast cancer, allowing safe delivery of higher daily doses than routinely used in practice. Of the 21 patients recruited for the trial, 18 were treated with Xeloda and reached a maximum tolerated dose of 2,000 mg twice daily. There were no grade 4/5 toxicities and grade 3 toxicities (which included one dose-limiting incident of hand-foot syndrome at 2,000 mg twice daily and two at 2,0
'/>"/>

SOURCE Roche
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 21, 2015 EUSA Pharma (EUSA), ... today announced the appointment of Lee Morley ... a Non-Executive Director.  Bryan Morton, who established EUSA Pharma ...   Lee Morley joins from ... Head of Commercial for Europe ...
(Date:4/20/2015)... WASHINGTON , April 21, 2015  Following is ... Bureau: LIFESAVING MEDICINE ... world,s most important medicines — insulin —became available for ... of millions of people suffering from diabetes. Insulin is ... in the processing of carbohydrates in the human body. ...
(Date:4/20/2015)... April 20, 2015 Research published today in ... Sciences (PNAS) demonstrates that technology invented by ... Casey Eye Institute can improve the clinical ... coherence tomography (OCT) angiography could largely replace current ... OHSU researchers found that OCT angiography ...
Breaking Medicine Technology:EUSA Pharma Appoints Lee Morley as Chief Executive and Industry Veteran Göran Ando to Board of Directors 2EUSA Pharma Appoints Lee Morley as Chief Executive and Industry Veteran Göran Ando to Board of Directors 3U.S. Census Bureau Daily Feature for April 21 2Study shows new technology may improve management of leading causes of blindness 2Study shows new technology may improve management of leading causes of blindness 3Study shows new technology may improve management of leading causes of blindness 4Study shows new technology may improve management of leading causes of blindness 5
... WAYNE, Pa., Oct. 23 Escalon Medical Corp. (Nasdaq: ... Solutions subsidiary released its Web-Based AXIS(TM) Image Management System. ... images from different sources into a single searchable database ... over time across multiple imaging modalities, and improve practice ...
... , BOSTON, Oct. 23 Solos Endoscopy, Inc. (Pink ... has received additional purchase orders for its MammoView(TM) line ... (NCI), as well as the U.S. National Institute of ... of Health and Human Services. Solos Endoscopy,s MammoView(TM) line ...
Cached Medicine Technology:Escalon(R) Subsidiary Escalon Digital Solutions Announces Release of Web-Based AXIS(TM) Image Management System 2Escalon(R) Subsidiary Escalon Digital Solutions Announces Release of Web-Based AXIS(TM) Image Management System 3Solos Endoscopy, Inc. Receives Additional Purchase Orders from National Cancer Institute and National Institute of Health for its MammoView(TM) Product Line 2
(Date:4/21/2015)... April 21, 2015 Carinsuranceshoppingsource.com has ... analyzing comprehensive auto insurance plans . , ... provides coverage for numerous situations. The coverage limit can ... Comprehensive auto insurance will protect a car against fire ... , Comparing quotes is no longer difficult and it ...
(Date:4/21/2015)... 2015 As a provider of holistic, ... that their rehabilitation strategy, which involves various treatment modalities, ... In an effort to offer hope and encouragement to ... lives, Best Drug Rehabilitation has featured a series of ... successful graduates of their recovery program. , One ...
(Date:4/21/2015)... April 21, 2015 April 21, 2015 ... by iData Research ( http://www.idataresearch.com ), growth within the ... new technologies and improvements in existing technologies. The most ... of motion preservation technology. Many companies are developing new ... in the markets for more traditional spinal fixation products. ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 Le Petit Retreat ... opened its doors today in the leafy, historic Larchmont neighborhood, ... look and a new theme of “Disconnect to Reconnect.” ... owner of the award-winning day spa, announces the new name ... special Mother’s Day offerings that help celebrate connections with Moms ...
(Date:4/21/2015)... has released a new blog post explaining how to ... , Eco-friendly cars can be important for the ... insurance agencies may even offer generous discounts for hybrid ... should consider the costs of auto insurance premiums. ... more to insure. Eco-friendly vehicles however, may be cheaper ...
Breaking Medicine News(10 mins):Health News:Comprehensive Auto Insurance Is An Important But Complex Policy 2Health News:Best Drug Rehabilitation Graduate Discusses Making Amends and Rebuilding Relationships 2Health News:Increasing Competition Driven by Technological Shifts in U.S. Spinal Implant Market; DePuy Synthes Continues to Challenge Medtronic’s Lead 2Health News:Increasing Competition Driven by Technological Shifts in U.S. Spinal Implant Market; DePuy Synthes Continues to Challenge Medtronic’s Lead 3Health News:Larchmont Sanctuary Spa Revealed as New Name For Neighborhood Spa; New Owner, New Eco Offerings & New Theme: “Disconnect to Reconnect” 2Health News:Larchmont Sanctuary Spa Revealed as New Name For Neighborhood Spa; New Owner, New Eco Offerings & New Theme: “Disconnect to Reconnect” 3Health News:Auto Insurance Quotes For Eco-Friendly Vehicles 2
... government has reneged on its pledge to provide more flexible ... Postgraduate Medical Journal. , Nearly 70% of medical students are ... women. , But despite its pledges in 2000, made in ... - and the policy commitment made by the pay negotiating ...
... on why some people suffer from recurrent episodes of ... by a drop in blood pressure, fainting episodes, difficulty ... these individuals, researchers have found mast cells (a type ... a mutated cell surface receptor that disturbs normal processes ...
... November 09, 2007 New research explains why ... despite similar surgical and post-operative treatment. The findings show ... times be explained by the different biological properties of ... cell tumors, and the exploration of specific tumor-targeted therapy, ...
... Promotes Environmental Protection Awareness, NORTH CHICAGO, Ill., Nov. ... Abbott (NYSE: ABT ) has donated a "Cool ... Chicago to the Lake,County Forest Preserves (LCFP) as a ... Chicago, Ill. The "Cool Globes" program, which Abbott ...
... NutraCea (OTC Bulletin Board:,NTRZ), a health science ... bran,(SRB), announced today that it will release its ... the market closes. Management will host the ... EST,to review NutraCea,s 2007 third quarter financial results ...
... The Menninger Clinic, the,international specialty psychiatric hospital in ... Epicenter -- that include The,Clinic,s new campus and ... and advocacy., Menninger will be located within ... South Main Street, near South Post Oak Road ...
Cached Medicine News:Health News:UK government has reneged on pledge for flexible working in NHS 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 3Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 2Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 3Health News:NutraCea to Host Third Quarter 2007 Financial Results Conference Call November 14 2Health News:The Menninger Clinic Unveils Plans for Mental Health Epicenter; Exceeds Halfway Point in $125 Million Capital Campaign 2Health News:The Menninger Clinic Unveils Plans for Mental Health Epicenter; Exceeds Halfway Point in $125 Million Capital Campaign 3
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
... AEM Laparoscopic Instruments incorporate a layered design ... shielded and monitored to prevent stray electrosurgical ... caused by insulation failure or capacitive coupling; ... shield built into all AEM Instruments provides ...
... The AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... The 5mm AEM Laparoscopic Instruments incorporate ... AEM Instruments are shielded and monitored to ... of the instrument caused by insulation failure ... risk. The protective shield built into all ...
Medicine Products: