Navigation Links
Novel Therapeutic Approaches May Transform Treatment and Improve Patient Outcomes in Several Platelet Disorders
Date:12/6/2008

ansfusions were the same in both arms.

Oral Eltrombopag for the Long-Term Treatment of Patients With Chronic Idiopathic Thrombocytopenic Purpura (ITP): Results of a Phase III, Double-Blind, Placebo-Controlled Study

[Abstract #400]

Gregory Cheng, ChineseUniversityof Hong Kong,Hong Kong,China

This double-blind, multicenter, phase III study found that long-term eltrombopag therapy compared with placebo treatment significantly increased platelet counts, decreased bleeding symptoms, allowed for a reduction of baseline ITP therapy, and reduced the use of rescue medications in previously treated patients with chronic ITP. In chronic ITP, low blood platelet counts persist unless treated and can last for an indefinite amount of time.

A total of 197 patients with platelet counts less than 30,000 microliters were stratified by splenectomy status, use of baseline ITP medication, and platelets of less than or equal to 15,000 microliters. They were randomized to receive either eltrombopag at a starting dose of 50 mg once daily (135 patients) or placebo once daily (62 patients). Depending on individual platelet response, the dose of eltrombopag could be titrated within a range from 25 mg once daily to a maximum dose of 75 mg once daily.

The primary endpoint of the study was the odds of achieving platelet counts between 50,000 and 400,000 microliters in patients receiving eltrombopag as compared with placebo. To measure the drug's safety, bleeding symptoms were prospectively evaluated using the WHO Bleeding Scale.

Patients who received eltrombopag were eight times more likely to achieve platelet counts of 50,000 to 400,000 microliters during the six-month treatment period as compared with those in the placebo arm. While baseline median platelet counts were 16,000 microliters in both
'/>"/>

SOURCE American Society of Hematology
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... PLAINFIELD, N.J. , Aug. 20, 2014 PTC Therapeutics, ... will participate at two upcoming investor conferences: - ... Seasons Hotel in Boston on Wednesday, ... Biotech Conference at The Mandarin Oriental Boston on Thursday, September ... present a company update at the Bank of America Merrill ...
(Date:8/20/2014)... YORK , Aug. 20, 2014 ... is available in its catalogue: The ... IVD Industry http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html ... Act" (H.R. 3590) is complex legislation that affects ... of its provisions are beginning to take effect ...
(Date:8/20/2014)... 20, 2014 Reportlinker.com announces that ... in its catalogue: Personal Accident ... and Opportunities to 2017 ... The report provides in depth market analysis, ... accident and health insurance segment, including: • ...
Breaking Medicine Technology:PTC Therapeutics to Participate at Upcoming Investor Conferences 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 2Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 3Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 4Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 5Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 6Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 7Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 8Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 9Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 10Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 11Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 12Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 13Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 14Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 15Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 16Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 17Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 18Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 19Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 20Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 21Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 22Personal Accident and Health Insurance in Canada, Key Trends and Opportunities to 2017 23
... REDWOOD CITY, Calif., March 19, 2012 Ingenuity Systems, ... life science researchers, today announced that the Weill Cornell ... iReport for use in its sequencing core facility.  Variant ... the output of whole genome and exome sequencing experiments ...
... 19, 2012  Johnson & Johnson (NYSE: JNJ) will provide ... parties on Monday, March 26th at approximately 10:30 ... College of Cardiology (ACC) Annual Scientific Sessions in ... of the EINSTEIN-PE study in treating patients with ...
Cached Medicine Technology:Weill Cornell Medical College Selects Ingenuity® Variant Analysis™ and Ingenuity® iReport™ for Sequencing Core Facility 2
(Date:8/21/2014)... TX (PRWEB) August 21, 2014 Sometimes you have ... , In his new book “From Zero to a Hundred: Finding ... officer, shares his story of surviving a broken family, a childhood ... brings affirmation of who you were created to be,” Roy said. ... which is why I know my purpose today of helping others ...
(Date:8/21/2014)... August 21, 2014 CQIIP, Continuous ... Centers for Disease Control and Prevention and the ... their compliance with the immunization standards and are ... CDC's General Recommendations on Immunizations. , ACC chose ... many procedures in place to protect patients, improve ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... aging interventions and addressing the challenges of ... concept, OncoFinder, for signalome-wide pathway analysis. ... robust cross-platform analysis of gene expression data ... research, published in the journal Frontiers in ...
(Date:8/20/2014)... Most people think of donating food around the ... for a variety of reasons—thus making these months some ... need, Dr. Bryne Willey of AlignLife of Springfield ... wanted to heighten awareness of the need in the ... in July food drive to collect non-perishable foods for ...
(Date:8/20/2014)... In less than a week the ... donations to fight muscle related disease. Helping the huge ... and brands through their cause-related marketing heft. With their ... raised nearly $60 million. , But for small self-serve ... franchisees, cause-related marketing remains decidedly local and, although the ...
Breaking Medicine News(10 mins):Health News:Zero to a Hundred: True Story of Escaping Death to Meet Life 2Health News:ACC Health Raises the Bar Again by Completing the CQIIP Certification Program 2Health News:OncoFinder, a new algorithm for minimizing errors in high-throughput transcriptome analysis 2Health News:AlignLife Springfield Office Donates 565 Canned Goods to Springfield Food Pantry 2Health News:On Eve of Big Telethon, Froyo Businesses Participate but Also Go Their Own -- Local Way 2Health News:On Eve of Big Telethon, Froyo Businesses Participate but Also Go Their Own -- Local Way 3
... A Bengali teenager, who won his battle with cancer, is ... story of his recovery from the deadly ailment. ... School in Siliguri, about 600 km from the state capital, ... with the financial support of cricketer Sourav Ganguly and his ...
... a unique feature. In addition to the attendance roster kept ... the students. ,This ingenious book keeps track ... been clipped, clothes are clean, hair is properly cut and ... and before eating. ,Schools have been identified as ...
... and ticking like a well-oiled machine, all you have to ... ,The finding is based on a new research ... and Michael J. Sheridan, Sc.D., of Inova Fairfax Hospital, who ... heart healthy fat, improves risk factors for heart disease with ...
... lead character smokes is not as effective a method as ... the appeal of smoking to , are non-smokers. ... the June issue of the journal Tobacco Control. ... whom were current smokers, aged 12-24 years in Australia, over ...
... through an entire life without contributing a huge amount to ... carbon footprint jumps . Alarmed by the fuel-intensive nature of ... firewood, an environmental group in New Delhi is promoting a ... we must do our last rites in this way," said ...
... out of the sun, especially in the initial stages of ... are more sensitive to high temperatures . ,The ... on the findings of a new study carried out by ... ,In this study, the researchers found that exposure to ...
Cached Medicine News:Health News:Where Children Lead the Sanitation Drive 2Health News:Where Children Lead the Sanitation Drive 3Health News:A Handful of Pistachios a Day Helps to Keep Your Heart Healthy 2Health News:New 'green' Pyre to Cool Planet While Burning India's Dead 2Health News:New 'green' Pyre to Cool Planet While Burning India's Dead 3
Superior imaging through a 410,000 pixel CCD, unseen color replication from a digital signal processor in the scope, and the added benefit of four way tip deflection make the TF410 a superior choice ...
The ACMI™ Operative Laparoscopy System is designed for single- and dual-incision CO2 laser procedures and is used with 45cm laparoscopic instruments....
Stryker autoclavable pediatric laparoscopes provide equivalent brightness and resolution along with the unparalleled durability found in larger laparoscopes....
The Olympus full range of laparoscopes includes a range of diameters and directions of view -12 mm HDTV compatible model as well as a choice of 10 mm, 5 mm full screen and 3 mm....
Medicine Products: