Navigation Links
Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells
Date:2/5/2008

hemolysis. There were no differences among the treatment groups in the overall frequency of painful crises, though crises experiences were infrequent in this study.

Senicapoc was safe and well tolerated in the study. Ten patients, five of whom were in the placebo group, discontinued the study early. Three patients dropped out due to adverse events: one in the low-dose group for weakness and shortness of breath, and two in the high-dose group for pain crises and acute chest syndrome. The most common serious adverse effect (SAE) was pain crisis, followed by pneumonia and acute chest syndrome, with a similar incidence across the active and placebo arms. None of the SAEs were thought attributable to senicapoc.

"The results we saw in this study provide further evidence that blocking the Gardos channel reduces dehydration of the sickle erythrocytes and thus supports the hypothesis that this type of approach may lead to an amelioration of the anemic state in patients with sickle cell anemia," said Dr. Ataga. "As noted in the paper, a Phase III study of senicapoc in SCD patients was recently terminated due to the low probability of achieving a reduction in crisis rate, the primary endpoint of that study. Clearly, further work is necessary to understand how the reduction in RBC dehydration and hemolysis demonstrated from the results of this Phase II study impacts the complex pathophysiology of sickle cell disease."

The American Society of Hematology (http://www.hematology.org) is the world's largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology.


'/>"/>
SOURCE American Society of Hematology
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima(TM)
2. First Patient Enrolled in Cogentus Pharmaceuticals Pivotal Phase 3 Trial of Novel Combination Medicine
3. Maxygen Announces Positive Progress in Phase IIa Clinical Trial of Novel PEG-GCSF
4. Celldex Therapeutics Receives Fast-Track Designation for CDX-110, a Novel EGFRvIII Vaccine for Glioblastoma
5. Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers
6. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
7. SuperGen Reports Initiation of Multi-arm Phase 1b Trial of Novel Tyrosine Kinase Inhibitor
8. PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium
9. Chroma Announces Positive Phase I Efficacy Data for Novel Cancer Therapy CHR-2797
10. Exelixis Presents Encouraging Phase 1 Data For XL019, A Novel Selective Inhibitor of JAK2
11. Preclinical Studies Show Promise for Novel Antibody Therapy to Treat Acute Myeloid Leukemia (AML)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Report Details  New ... companies  What does the future hold for ... Visiongain,s brand new report shows you potential revenues to ... Our 242-page report provides 185 tables, charts, and ... and the future market prospects. Our new study lets ...
(Date:3/27/2015)... , March 27, 2015   Hospira, Inc. ... in biosimilars and the world,s leading provider of ... that support an evaluation of biosimilarity of its ... and Drug Administration (FDA) conditionally approved name of ... (epoetin alfa). These study data were presented at ...
(Date:3/27/2015)... March 27, 2015 Concord Medical Services ... CCM ), a leading specialty hospital management ... of radiotherapy and diagnostic imaging centers in ... of a purchase agreement under which Concord Medical ... of the Company, agreed to acquire the Fortis ...
Breaking Medicine Technology:Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 2Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 3Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 4Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 5Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 6Pharma Leader Series: Top 25 Ophthalmic Drug Manufacturers 2015-2025 7Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 2Hospira Clinical Data Shows Proposed Biosimilar, Epoetin Hospira, Demonstrates Pharmacokinetic And Pharmacodynamic Equivalence Compared To Amgen's Epogen 3Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 2Concord Medical Announces Acquisition of Fortis Surgical Hospital in Singapore 3
... Global Health Solutions Corporation (OTCBB: RHSC) and Montana ... have signed a commercial agreement with Telemedicine Africa to ... solutions to the medically underserved population of Africa through ... Telemedicine Africa aim to deliver RHealth Advisor mobile web ...
... NEW YORK, Oct. 19, 2011 The New York eHealth ... awards for individuals who have made tremendous contributions to the ... be presented on the first night of the NYeC Digital ... look forward to bringing together the many people leading the ...
Cached Medicine Technology:Robertson Global Health Solutions Announces Commercial Venture with Telemedicine Africa 2Robertson Global Health Solutions Announces Commercial Venture with Telemedicine Africa 3Robertson Global Health Solutions Announces Commercial Venture with Telemedicine Africa 4New York eHealth Collaborative Announces Winners for its Digital Health Conference Gala Awards 2
(Date:3/27/2015)... 2015 The federal court overseeing thousands ... statin medication increases the risk that a patient will ... to Dismiss four individual cases that had been filed ... issued in the U.S. District Court, District of South ... dismissals were warranted because the plaintiffs in those claims ...
(Date:3/27/2015)... On February 21, 2015, Choices ... Stardust Penthouse on the rooftop of the luxurious ... sustainable product TV and film placement producer, was ... which featured some of the world’s top providers ... services. , “We were honored to have a ...
(Date:3/27/2015)... According to a recently published report series ... screw market in Europe is in decline due to ... segment. Price decreases are being seen across the entire ... the total European trauma device market, continued pricing pressure ... year after year. , “Such price drops are ...
(Date:3/27/2015)... According to Health Day , on ... Abstinence Syndrome (NAS) are causing alarm for Florida officials. ... process for a month of their lives- and can ... vomiting. The condition is precipitated by drug use during ... (and employing medically assisted drug treatment) will also inflict ...
(Date:3/27/2015)... March 27, 2015 When struck with ... hard to know where to begin. The latest ... trucking accident attorney, offers accident victims a clear and ... assistance to ensure their personal injury claim is seen ... describing the first actions that should be taken immediately ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:Choices Recovery Releases 'Salute to the Oscars' EcoLuxe Lounge Compilation Video 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 2Health News:Titanium Trauma Treatment Devices in Europe Becoming More Affordable, Decreasing Market Value: Group Purchasing Further Eroding Selling Prices 3Health News:In Florida Only 10% of Pregnant Mothers Are Referred to Drug Rehab Despite Testing Positive for Narcotics 2Health News:Dax Jones Updated eBook on Trucking Accidents Offers Helpful Information to Crash Victims 2
... wellbeing in rich countries might depend more on reductions in ... study published today on bmj.com . , Poorer ... But a recent UNICEF report detailing 40 indicators of ... fared worse than in any of the other rich countries. ...
... (NYSE: WPI ), a leading specialty pharmaceutical,company, ... 48, as Senior,Vice President and Chief Financial Officer. ... 20 years of executive,pharmaceutical experience in finance, operations, ... Chief Financial Officer for Watson,Mr. Durand will be ...
... of families with deployed Service members ... ... to the Oregon National Guard,s Emergency Relief fund, which,will support the needs of ... "TriWest made the contribution with the hope that we can make a,difference in ...
... Use of ABILIFY in Patients Ages 10 to 17 ... ... PRINCETON, N.J., Nov. 15 ,Otsuka Pharmaceutical Co., Ltd. and Bristol-Myers Squibb Company ... for filing and granted a Priority Review to the supplemental New,Drug Application ...
... alternative for patients with erosive gastroesophageal reflux disease ... (GERD) who cannot swallow ... of Wyeth (NYSE: WYE ), announced today that the,U.S. ... Delayed-Release Oral Suspension, a new addition,to the Protonix family of ...
... Memphis PGA Tour Stop ... Jude, MEMPHIS, Tenn., Nov. 15 Stanford Financial Group CFO,James ... joined Tony,Thomas from St. Jude and Laurie Tucker, Senior Vice President ... from the,inaugural Stanford St. Jude Championship. The donation from the 2007 ...
Cached Medicine News:Health News:Low standards of child well-being linked to greater income inequality 2Health News:Watson Names Mark Durand Chief Financial Officer 2Health News:TriWest Contributes $30,000 to Oregon National Guard Fund 2Health News:ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration 2Health News:ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration 3Health News:ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration 4Health News:ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration 5Health News:ABILIFY(R) (aripiprazole) Supplemental New Drug Application for the Treatment of Pediatric Patients with Bipolar I Disorder Accepted for Priority Review by the U.S. Food and Drug Administration 6Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 2Health News:Wyeth Receives FDA Approval of Protonix for Delayed-Release Oral Suspension 3Health News:Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Children's Research Hospital(R) 2Health News:Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Children's Research Hospital(R) 3Health News:Stanford St. Jude Championship Presents $1.76 Million Donation To St. Jude Children's Research Hospital(R) 4
Softwear Saline with unique comfort rinsing formula....
Sensitive Eyes sterile saline spray is the preservative-free aerosol saline solution for people with eyes sensitive to preservatives. Used for rinsing soft contact lenses after cleaning or thermal or...
Ultrazyme enzymatic cleaner works in a single step, taking as little as 15 minutes for cleaning....
... specialty Eraser instruments have been designed ... the right tool for situations requiring ... series of 25 gauge intraocular, bipolar, ... treatment of target tissues for fine-tip ...
Medicine Products: