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Novel Compound Shows Promise for Treatment of Alcoholism
Date:9/11/2008
BIRMINGHAM, Ala., Sept. 11 /PRNewswire-USNewswire/ --- Southern Research Institute and Gallo Research Center today announced that peer-reviewed results from a study testing Naltrexone-derived pyridomorphinan (SoRI-9409) will be published in the December 2008 issue of the journal Biological Psychiatry. The publication is available online today at the journal's website, and suggests that a new compound that causes selective and long-lasting reduction in ethanol consumption might be a promising candidate as a novel treatment for alcoholism.
The article, "A Novel Delta Opioid Receptor Antagonist, SoRI-9409, Produces a Selective and Long-Lasting Decrease in Ethanol Consumption in Heavy-Drinking Rats" by Selena Bartlett, BPharm PhD, Director of Preclinical Development Group at the Gallo Research Center at University of California San Francisco, et al presents the effects of SoRI-9409 on ethanol consumption. These are promising developments for the treatment of alcoholism. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) estimates 15.1 million people are alcohol-abusing or alcohol-dependent individuals. There are currently only three FDA-approved options for the treatment of alcoholism.
The compound, SoRI-9409, was first designed and synthesized in Southern
Research's Drug Discovery research division by Dr. Subramaniam (Sam)
Ananthan under U.S. Government Grant DA008883. "Southern Research has been
particularly interested in ligands that interact with opioid delta receptor
subtype since such ligands hold promise as therapeutic agents for treatment
of drug addictions and other disorders," said Dr. Ananthan, senior
scientist and manager of Computational Chemistry and CNS Discovery
Chemistry at Southern Research Institute. "The present findings by Dr.
Bartlett and her group on the effect of SoRI-9409 on its ability to reduce
alcohol intake not only provides us with a new drug lead, but also serves
as the impetus for further research aimed at
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| SOURCE Southern Research Institute Copyright©2008 PR Newswire. All rights reserved |
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