Navigation Links
Novel Approach May Protect Against Heart Attack Injury
Date:7/10/2008

- Drugs Target Gene Pathways to Preserve Heart, Possibly Other Organs -

PHILADELPHIA, July 10 /PRNewswire-USNewswire/ -- Researchers at The Children's Hospital of Philadelphia have manipulated cell activity that occurs during the interruption of blood flow to strongly protect heart tissue in animal studies. The finding has the potential to become an emergency treatment for heart attack patients, particularly since already existing drugs might be pressed into service to produce the protective effects.

"Reduced blood flow, or ischemia, is a major problem in many organs, where it can lead to cell death and tissue damage," said study leader Peter J. Gruber, M.D., Ph.D., a cardiothoracic surgeon at Children's Hospital and a faculty member of the University of Pennsylvania School of Medicine. "We decided to look for a global approach to protecting heart tissue by inhibiting enzymes that govern how cells respond to ischemia."

Gruber's team published their findings online July 7 in the journal of the Federation of American Societies for Experimental Biology (FASEB). The article will appear in the journal's October 2008 print issue.

The researchers made use of drugs called histone deactylase (HDAC) inhibitors that alter the way DNA is packaged within cells, as well as modifying the function of other proteins. Building on previous work by other researchers, who showed that HDAC inhibitors reduce ischemic injury in the brain, they used the same agents in mice with induced heart damage.

"We found significant and dramatic results in the mice," said Gruber. "The HDAC inhibitors reduced the area of tissue injury, even when delivered an hour after the ischemic event occurred." The size of the myocardial infarction--an area of dead tissue caused by obstructed blood flow, as occurs after a heart attack--was reduced by more than half.

In further investigating how the HDAC inhibitors acted, Gruber's team found they blocked gene pathways
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Embryo Viability Studies Support Utility of Novel, Metabolomic Profiling Technology
2. Bad News to Bad Bugs: Northern Antibiotics Develops Novel Polymyxins With Reduced Toxicity
3. DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin
4. Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
5. Fox Chase Cancer Center and VisEn Medical Announce Program to Advance First Clinical Trials of Novel Fluorescence Molecular Imaging Technologies
6. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
7. Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma
8. New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma
9. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
10. Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD
11. deCODE Discovers Novel Genetic Links Between Pigmentation Traits and Risk of Skin Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... , December 15, 2014 Heptares ... company, is pleased to announce the grant of multiple ... relating to its GPCR-focused drug discovery platform. The ... the global patent estate covering Heptares, technologies and products ... of patents recently granted by the US Patent Office ...
(Date:12/13/2014)... 2014  Radiologists can transmit their reports, which ... referring physicians, electronic health records (EHR) systems securely, ... That was the message behind ... at the recent Radiology Society of North America ... reports in this manner also helps referring physicians ...
(Date:12/13/2014)... PLAINSBORO, N.J. and INDIANAPOLIS , ... diabetes care, and Chip Ganassi Racing Teams (CGRT), today announced ... Nordisk as the primary sponsor of the No. 83 Novo ... in the Verizon IndyCar Series. Kimball, ... first and only licensed driver with diabetes in the history ...
Breaking Medicine Technology:Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 2Advanced Data Systems Presents on Interface-Free EHR Communications at RSNA's 2014 Conference: Streamlining Communication of Reports and Images to Referring Physicians 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 2Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 3Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 4Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 5Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 6Novo Nordisk and Chip Ganassi Racing Teams Announce Multi-Year Sponsorship Agreement for Verizon IndyCar Series 7
... SILVER SPRING, Md., Nov. 15, 2011 Nov. ... joint effort by the Food and Drug Administration ... and other health care professional, government, academic, international ... of antibiotics.  (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO) ...
... Medical Simulation Corporation (MSC) is proud to offer innovative, ... funding through the Health Care Innovation Challenge, announced on ... Human Services. Simulation provides a unique, risk-free ... skills in managing patients with diagnoses associated with high ...
Cached Medicine Technology:FDA Consumer Health Information - Video: Get Smart About Antibiotics 2Medical Simulation Corporation Offers Innovative Training Solutions for Healthcare Organizations Applying to the Department of Health and Human Services' Health Care Innovation Challenge 2
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Cardiac Arrest Association, offers heart healthy Valentine,s Day gift ideas ... by the celebration of Valentine,s Day and a great time ... will splurge on jewelry, flowers and other luxuries, why not ... and healthy at heart? "Every two minutes, someone in the ...
... among 1,189 Initiates from around the world who became Fellows of the ... annual Clinical Congress in San Francisco. , ... Chicago (PRWEB) February 3, ... from around the world who became Fellows of the American College of ...
... Ethicon Endo-Surgery (a Johnson & Johnson company), the ... among the first bariatric surgeons in the U.S. ... generation of its distinctive surgical weight loss method: ... is gaining a reputation as being one of ...
... 3 Press Ganey Associates, Inc. and the Harvard ... formally announced continued collaboration through 2009. The two organizations, ... and innovation, are combining their expertise and reach to ... how to adapt to the changing face of health ...
... Michigan Orthopedic ServicesDETROIT, Feb. 2 Huron Capital Partners ... ("MOS") has acquired O&P Professional Care as part of ... The business will be managed under the MOS ... MOS operates a network of 11 patient care ...
... For many cancer patients, chemotherapy can be worse than cancer ... not another -- or the tumor may mutate and stop ... time, ineffective treatment and toxic side effects. , ... one day allow doctors to evaluate a tumor,s response to ...
Cached Medicine News:Health News:The Sudden Cardiac Arrest Association Shoots Straight for the Heart 2Health News:The Sudden Cardiac Arrest Association Shoots Straight for the Heart 3Health News:Dallas Surgeon Among 1,189 Initiated Into American College of Surgeons 2Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 2Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 3Health News:Dallas – Fort Worth Bariatric Surgeon Dr. David Kim One of Few in America Selected to Perform New Weight Loss Surgery Procedure 4Health News:Press Ganey and Harvard's Forces of Change Announce 2nd Annual Collaboration 2Health News:Press Ganey and Harvard's Forces of Change Announce 2nd Annual Collaboration 3Health News:Huron Capital Continues Acquisition Activity 2Health News:UCLA scientists develop crystal ball for personalized cancer treatment 2
... Disc is a Hand Assisted Laparoscopic Surgery ... the surgeons hand may facilitate the procedure, ... has applications in colorectal, urological and general ... extracorporeal extension of pneumoperitoneum and abdominal access ...
... SleepStyle 200 series offers a range ... models. The design delivers therapy to ... features promote results in commercial and ... strongest differentiator in the SleepStyle 200 ...
... 200 series offers a range of ... The design delivers therapy to meet ... promote results in commercial and clinical ... differentiator in the SleepStyle 200 series ...
... S6 Lightweight II CPAP has sound ... that maintains consistent pressure. The backlit ... the settings easy, and the interface ... adjustments is simple. This CPAP device ...
Medicine Products: