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Novel Apolipoprotein A-I Therapy, CSL112, May Represent New Option for Reducing Recurrent Heart Attack Risk, Early CSL Studies Show
Date:11/5/2012

nd time-dependent manner and were maintained for at least 72 hours after infusion of CSL112 at 40 mg/kg and higher. Notable biomarker changes included elevations in PreBeta1-HDL (maximum=3,600%) and global cholesterol efflux capacity from macrophages (maximum=270%).  

In another study presented at the meeting, CSL112 was observed to have strong anti-inflammatory properties in human blood ex vivo. This property of CSL112 may prove to be beneficial in the reduction of inflammation associated with cardiovascular events.

"We are very encouraged by the early experience with CSL112 in the clinic and are looking forward to completing the mid-stage studies that are now in progress or being planned to start next year," said Chuck Shear, CSL Senior Director and Therapeutic Area Head.

About CSL112
CSL112 is a novel formulation of apolipoprotein A-I (ApoA-I), the chief component of high-density lipoprotein (HDL). It is purified from plasma and reconstituted to form HDL suitable for intravenous infusion. As demonstrated in pre-clinical and Phase 1 studies, CSL112 elevates cholesterol efflux capacity, as well as additional steps in reverse cholesterol transport. CSL112 demonstrates strong anti-inflammatory activity, as well.

About CSL
Headquartered in Melbourne, Australia, CSL Limited is a global biopharmaceutical company that develops, manufactures and markets biotherapies to prevent and treat rare and serious human diseases. CSL owns major facilities in Australia, Germany, Switzerland and the United States, and employs over 11,000 people in more than 25 countries. Visit www.csl.com.au for more information.

Contact

Sheila A. Burke
Director, Communications & Public Relations
Worldwide Commercial Operations
CSL Limited
C: 484-919-2618 (US)
Sheila.Burke at cslbehring.com

Eliot Harrison
MCS Healthcare Public Relations
C: 908-884-5252

SOURCE CSL Limited
Copyright©2012 PR Newswire.
All rights reserved

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