Navigation Links
Novel Apolipoprotein A-I Therapy, CSL112, May Represent New Option for Reducing Recurrent Heart Attack Risk, Early CSL Studies Show
Date:11/5/2012

e course after the first and last infusions.

An overall elevation in cholesterol efflux capacity, PreBeta1-HDL, and HDL in serum or plasma was observed among all dosing regimens. PreBeta1-HDL was increased 20-fold among dosing regimens. Cholesterol efflux capacity and PreBeta1-HDL peaked immediately following infusion and returned to near baseline at 24 hours. HDL level increased following PreBeta1-HDL, peaked at 24 to 48 hours, and sustained elevation 72 hours after infusion.

Safety and PK profiles were separately evaluated in the 36 healthy patients receiving the three dosing regimens of CSL112.  No treatment-emergent serious adverse events (AE) were reported, no abnormalities were observed in serum biochemistry, hematology and urine parameters, and no significant changes were seen in platelet function, vital signs or ECG associated with CSL112 treatment. The most common AE reported was vessel puncture site hematoma (18 of 36), which was reported by similar proportions of patients receiving either CSL112 or placebo.

"Development of products that increase cholesterol efflux from the artery wall represents an emerging area in atherosclerosis discovery," said Dr. Samuel Wright, PhD, Global Strategic Director for Cardiovascular Therapeutics at CSL Limited and study co-author. "Prior approaches have centered on addressing only HDL cholesterol levels. CSL112 holds promise as a new therapy that may be used in addition to other treatments, such as anti-platelet agents, to provide early event reduction."

Additional CSL112 Research
Data from a randomized single ascending dose study of 57 healthy subjects were also presented at the AHA 2012 Scientific Sessions and demonstrated that a single infusion of CSL112 at dose levels of 5 to 135 mg/kg immediately caused dose-proportional elevation in apoA-I and changes to key biomarkers of the early steps in reverse cholesterol transport. These changes from baseline occurred in a dose- a
'/>"/>

SOURCE CSL Limited
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Novelos Therapeutics Closes $2 Million Private Placement
2. RayBiotech, Inc. and Abeome Corporation Announce an Agreement Related to Novel Research Products for Ovarian Cancer
3. Global eClinical Trial Solutions Market to 2018 - Growing Complexity of Clinical Trials and Increased Focus on Accuracy and Efficiency Drive Trial Sponsors to Adopt Novel Technologies: MarketResearchReports.Biz
4. Novelos Therapeutics Announces Enrollment of First Patient in Solid Tumor Imaging Trial with I-124-CLR1404 (LIGHT) Cancer-targeted PET Imaging Agent at UW Carbone Cancer Center
5. Constellation Pharmaceuticals and The Leukemia & Lymphoma Society Partner to Develop Novel BET Inhibitor for the Treatment of Hematologic Malignancies
6. Frost & Sullivan Lauds IncellDx for Developing a Novel, Non-invasive Method for Cervical Cancer Testing
7. Novelos Therapeutics Successfully Completes Second Cohort In Phase 1b Solid Tumor Trial With I-131-CLR1404 (HOT) Cancer-Targeted Molecular Radiotherapeutic
8. MedImmune and WuXi AppTec Announce Joint Venture to Develop Novel Biologic for Chinese Market
9. Novelos Therapeutics And Academic Collaborators Present Three Posters At 2012 World Molecular Imaging Congress
10. Strategic Agreement Launches Novel Drug Development Model
11. Kalidex Introduces Novel Fluoroquinolone, KPI-10, at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... N.J. , Jan. 23, 2015  CytoSorbents Corporation ... commercializing its CytoSorb® extracorporeal cytokine adsorber to reduce ... announced the receipt of $385,642, net of transaction ... of the Technology Business Tax Certificate Transfer Program ...
(Date:1/23/2015)... Jan. 23, 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... in the development and sale of patented biopharmaceutical medicine, ... pharmaceutical ingredients (API) today announced the business and development ... 1. Following the September 2014 JCM application ...
(Date:1/22/2015)... Jan. 22, 2015  ResMed Inc. (NYSE: RMD ) ... Revenue for the quarter was $423.0 million, a 10 percent ... 14 percent increase on a constant currency basis). Net income ... the quarter ended December 31, 2013. Diluted earnings per share ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11
... ... ... ... ...
... ... ... ... ...
Cached Medicine Technology:Watson Signs Agreement to Divest Equity Interest in ScinoPharm 2Watson Signs Agreement to Divest Equity Interest in ScinoPharm 3Watson Signs Agreement to Divest Equity Interest in ScinoPharm 4Watson Signs Agreement to Divest Equity Interest in ScinoPharm 5HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 2HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 3HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 4HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 5HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 6HIMSS Honors Memorial Healthcare System for Using TheraDoc(TM) Decision Support Technology to Achieve 97 Percent Compliance With Pediatric Asthma Quality Measures 7
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put together ... by up to 30lbs in less than 12 weeks without ... Stevenson, prompting an investigative review. , “Our Incredible Bulk ... formula that allows the body to pack on a massive ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 The ... ) in the U.S. District Court, Southern District of West ... Bard, Inc. in that proceeding’s first bellwether trial. In an ... for a new trial after finding that C.R. Bard had ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
(Date:1/22/2015)... New York, NY (PRWEB) January 22, 2015 ... American College of Sports Medicine flagship journal Medicine ... supplementation with L-Citrulline before exercise may help reduce ... strenuous exercise. 1 , Participants in the ...
(Date:1/22/2015)... Four years since the release of their debut recording ... marriage of Avasa & Matthew Love – the duo are pleased ... release through White Swan Records on February 24, 2015. , THE ... path available to all of us to walk out of the ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 2Health News:THE ROAD by Avasa & Matthew Love -- A New Album 3Health News:THE ROAD by Avasa & Matthew Love -- A New Album 4
... ... 10%, there are many Americans struggling to find steady employment in a highly competitive market. ... cosmetic treatments to provide a more youthful, refreshed appearance. Non-surgical med spa treatments can offer ... ...
... ... a qualified medical professional. Award-winning Board Certified New York City Plastic Surgeon, Dr. Keith Berman offers ... ... to achieve the ultimate healthy and fit body is a constant goal and with hundreds of ...
... stem cells from generating new tumors , THURSDAY, May 6 ... the fight against breast cancer. , At least in mice, ... kill breast cancer stem cells, which help tumors grow, according ... if the compound would work in people. And the amount ...
... and effective alternative to the conventional treatment of hamstring ... the ARRS 2010 Annual Meeting in San Diego, CA. ... Hamstring tendonitis refers to inflammation (pain, swelling, warmth, ... hamstring tendons. It is relatively common in a multitude ...
... ... Association (AWWA) joins water professionals across North America in encouraging everyone to play a role ... ... Week continues, American Water Works Association (AWWA) joins water professionals across North America ...
... ... Nurses Week, May 6-12, , ... (PRWEB) May 6, 2010 -- HealthCareerWeb.com, a division of Dominion Enterprises, is ... during National Nurses Week, May 6th through May 12th. Nurses and/or those who appreciate ...
Cached Medicine News:Health News:Med Spa Treatments Become More Popular as Unemployment Rates Climb 2Health News:Med Spa Treatments Become More Popular as Unemployment Rates Climb 3Health News:Dr. Keith Berman's Beach Body Secrets: 7 Simple Tips for Weight Loss Success 2Health News:Dr. Keith Berman's Beach Body Secrets: 7 Simple Tips for Weight Loss Success 3Health News:Broccoli May Help Battle Breast Cancer 2Health News:Water Community Stresses Importance of Security During Drinking Water Week 2Health News:HealthCareerWeb.com "Appreciates Nurses A Latte" 2
Small bulbous tip with flat sides. Flat serrated handle with polished finish. Overall length: 5.1 inches....
7 mm flattened hook. Flat serrated handle with polished finish. Overall length: 4.9 inches....
Titanium. Small "H" shaped push-pull tip. Shaft angled 45 degrees, 9 mm from tip. Round knurled handle with dull finish. Overall length: 4.8 inches. Most popular size or model....
Right angled 5 mm blunt hook. Overall length: 9.9 inches....
Medicine Products: