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Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference
Date:2/17/2009

nsists of disposable, ready-to-use equipment. Current yields are more than 20 times higher than that of traditional egg-based or mammalian cell culture manufacturing. Because the Novavax process involves recombinant technology and does not require a live influenza virus, vaccine can be manufactured within 10 to 12 weeks of identification of a pandemic strain, approximately 50% of the time duration required to manufacture egg-based vaccines. As a key commercialization initiative, Novavax is collaborating with GE Healthcare, a unit of General Electric Company (NYSE: GE), to develop processes using disposable systems as its manufacturing approach. This manufacturing approach permits rapid commissioning at a fraction of the cost of traditional, egg-based manufacturing facilities. Novavax's VLP vaccine, combined with this manufacturing approach may be an effective and affordable component of a pandemic solution for countries that do not currently have in-border pandemic vaccine production.

Support for VLP Seasonal Influenza Vaccine Candidate

Novavax has a seasonal influenza VLP vaccine candidate in Phase II clinical trials as well. As previously announced, this vaccine candidate also induced strong HAI titers against strains that cause annual epidemics of influenza each year (H3N2, H1N1, and B). Seasonal influenza causes over 500,000 deaths worldwide and over 36,000 deaths in the U.S. each year, most of which occur in adults 65 years of age and older, a population in which currently licensed vaccines have only modest efficacy. While current seasonal vaccines consist almost entirely of HA, similar to the pandemic VLP vaccine, Novavax's seasonal influenza VLP contains HA, NA, and M1 with the potential of inducing neutralizing antibody to prevent infection and reduce the severity of influenza illnesses and pneumonia. Further studies
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SOURCE Novavax, Inc.
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