Navigation Links
Novartis highlights research on investigational, personalized T cell therapy CTL019 in patients with forms of acute and chronic leukemia
Date:12/7/2013

EAST HANOVER, N.J., Dec. 7, 2013 /PRNewswire/ -- Novartis is highlighting new research from members of the faculty at the University of Pennsylvania's Perelman School of Medicine (Penn) on the investigational chimeric antigen receptor (CAR) therapy, CTL019. Several studies being presented at the American Society of Hematology (ASH) annual meeting add to the scientific understanding of CTL019 in the treatment of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) and build on earlier research findings1,2,3,4.

"These data reflect a significant advance in our understanding of the novel, investigational CAR therapy, CTL019, which shows potential for advancing the treatment of patients with ALL and CLL," said Herve Hoppenot, President, Novartis Oncology. "We are committed, through our collaboration with Penn, to expand the clinical trials of CTL019 to include as many patients as soon as possible."

Highlights of the presentations include findings that 19 of 22 pediatric patients with ALL (86%) experienced complete remissions. The first pediatric patient treated with the protocol remains in remission 20 months later. Five pediatric patients have relapsed, including one whose tests revealed new tumor cells that do not express the CD19 protein targeted by the reprogrammed cells. Additionally, all five of the first adult ALL patients treated to date have experienced complete remissions, the longest of which continues six months after treatment. One adult patient subsequently underwent a bone marrow transplant and remains in remission. Another adult patient relapsed after three months with disease that also tested negative for the CD19 protein (abstract #67)1.

In studies of adult patients with CLL, 15 of 32 adult patients (47%) responded to the therapy, with seven of those experiencing a complete remission of their diseas
'/>"/>

SOURCE Novartis
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. 2013 ISPE Facility of the Year Awards Program Names Novartiss United States Flu Cell Culture Facility as Overall Winner
2. Novartis Group calls on FDA to maintain the well-established naming policy for all biologics to help ensure patient safety
3. Novartis begins shipment of seasonal influenza vaccines to US market
4. Novartiss Serelaxin Has the Potential to Fulfill the Most Pertinent Unmet Needs in Acute Heart Failure by Reducing the Rate of Patient Mortality and the Rate of Worsening Renal Function
5. Novartis Breakthrough Therapy LDK378 shows a marked clinical response in patients with ALK+ non-small cell lung cancer
6. Novartis Pharmaceuticals Corporation disputes allegations in two US Government lawsuits and looks forward to a fair discussion of the facts
7. Novartis signs on to support Malaria No Mores Power of One campaign to stride towards a future without malaria
8. Novartis Reports Omalizumab Significantly Improved Chronic Idiopathic Urticaria Symptoms in Patients Who Failed Standard Therapy
9. Novartis Pharma Logistics, Inc. voluntarily recalling in Jamaica select lots of certain over-the-counter products due to bottle closure defect
10. Novartis Pharma Logistics, Inc. voluntarily recalling in Trinidad & Tobago select lots of certain over-the-counter products due to bottle closure defect
11. Novartis Pharma Logistics, Inc. voluntarily recalling in Curacao select lots of certain over-the-counter products due to bottle closure defect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... MADRID , October 30, 2014 ... build tolerance for cow milk   Cow milk protein allergy ... infants and early childhood. Until now, it has been ... Recently, it has been shown that it is possible ... in a significant number of children during the first ...
(Date:10/30/2014)... , Oct. 29, 2014 The ... basis of test type, technology, product, and geography. ... the highest growth rate in the newborn screening ... high growth is attributed to various nations opting ... a fundamental instrument used for expanded newborn screening. ...
(Date:10/30/2014)... 2014 Hospital stretchers are apparatus used ... another, inside or outside of medical infrastructure premises. ... also used for several specialized functions such as ... platforms. The hospital stretchers market report ... market potential of hospital stretchers globally. The hospital ...
Breaking Medicine Technology:Experts Present Latest Research at Allergy Day 2Experts Present Latest Research at Allergy Day 3NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 2NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 3Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Hospital Stretchers Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 3
... MORRISVILLE, N.C., Aug. 31 TeleTracking Technologies, ... includes temperature measurement that is NIST traceable and ... temperature sensors certified to be waterproof and dustproof ... even in potentially damaging environmental conditions to extend ...
... 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT... -- DALLAS, Texas, August 31, 2010 ... ... --> ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the first ...
Cached Medicine Technology:NIST-traceable Temperature Tracking Provides Visual Alert RadarFind Sensor Now Waterproof Certified 2NIST-traceable Temperature Tracking Provides Visual Alert RadarFind Sensor Now Waterproof Certified 3The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 2The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 3The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 4The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 5The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 6The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 7The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 8The Top 10 Cardiovascular Device Companies: Market Trends, Growth Strategies, and SWOT Analyses Now Available at ReportsandReports 9
(Date:10/30/2014)... Steven Reinberg HealthDay Reporter , ... to men with prostate cancer who also have certain heart ... cause, a new study suggests. , , The therapy in question ... cancer to reduce levels of male hormones to prevent the ... the current research, this hormone therapy was linked to triple ...
(Date:10/30/2014)... Horse Sense & Sensitivity ... special needs individuals in the Jacksonville area, will be ... from 10-2:00 p.m. at Bailey's Farm (2202 Bishop Estates ... public and is designed to raise awareness and funds ... HSS Round-Up is free. Ticket purchases will be required ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 The annual ... (NAMS) came to a close on Saturday, October 18th, ... the Society’s inception in 1989. NAMS is North America’s ... quality of life of all women during midlife and ... With over 2,000 physicians and thought leaders from fields ...
(Date:10/30/2014)... HealthDay Reporter WEDNESDAY, Oct. ... chemical during pregnancy may have effects on genital development in ... baby boys born to moms with greater exposure to a ... -- the space between the genitals and anus. Anogenital distance ... of exposure to androgens ("male" hormones) during pregnancy. The ...
(Date:10/30/2014)... 29, 2014 (HealthDay News) -- A new vaccine that ... disease was approved by the U.S. Food and Drug ... people between the ages of 10 and 25 from ... serogroup B bacteria. The bacteria can infect the ... cord and brain. It is a leading cause of ...
Breaking Medicine News(10 mins):Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Horse Sense & Sensitivity, Jacksonville Non-profit, To Hold 2nd Annual Round-Up 2Health News:Highlights from The North American Menopause Society 25th Annual Meeting 2Health News:Highlights from The North American Menopause Society 25th Annual Meeting 3Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 3Health News:FDA Approves New Vaccine to Protect Against Meningitis 2
... SOMERSET, N.J., Jan. 9 TeamStaff, Inc.,(Nasdaq: ... administrative,staffing services, today announced that on January 4, ... Nasdaq Stock Market ("Nasdaq"),indicating that TeamStaff,s common stock ... The Nasdaq,s determination was based on its July ...
... combat mortality , , WEDNESDAY, Jan. 9 (HealthDay News) -- ... question the conventional wisdom of treating with corticosteroids, intensive ... called pentastarch. , The first study compared the ... septic shock and found no improvement in survival rates. ...
... made that New Years resolution to exercise more, but already youre ... You know all the benefits of a healthy lifestyle: In addition ... been linked to reduced depressive symptoms and reduced risk for heart ... TV instead of going for a short jog is just too ...
... ROUGE, La., Jan. 9 The 11th annual ... Forum,entitled "Eliminating Disparities and Improving Access to,Relationship-Centered Care," ... Inn,Select, 4728 Constitution Avenue, Baton Rouge, La., from ... is redesigning patient-care delivery and improving access to,its ...
... Group Inc.,(Nasdaq: GSIG ), a leading manufacturer of ... be presenting at both the,Needham & Company 10th Annual ... the Fifth Annual Sidoti & Company Emerging Growth Conference ... Bowen, Chief Financial Officer, will be speaking at both,events., ...
... Americans increasingly seek a quick fix to physical and ... of a debate about the potential benefits and drawbacks ... panel discussion entitled, The Uses of Medications in Psychoanalysis: ... by internationally renowned psychoanalyst Glen O. Gabbard, M.D., at ...
Cached Medicine News:Health News:TeamStaff Receives Nasdaq Determination Letter 2Health News:TeamStaff Receives Nasdaq Determination Letter 3Health News:Standard Septic Shock Treatments Ineffective 2Health News:Standard Septic Shock Treatments Ineffective 3Health News:Standard Septic Shock Treatments Ineffective 4Health News:Exercising judgment: The psychology of fitness 2Health News:Exercising judgment: The psychology of fitness 3Health News:Exercising judgment: The psychology of fitness 4Health News:Exercising judgment: The psychology of fitness 5Health News:Exercising judgment: The psychology of fitness 6Health News:Exercising judgment: The psychology of fitness 7Health News:Exercising judgment: The psychology of fitness 8Health News:Exercising judgment: The psychology of fitness 9Health News:Exercising judgment: The psychology of fitness 10Health News:LSU Forum Examines Health-Care Disparities and Access to Care 2Health News:GSI to Present at Upcoming Investor Growth Conferences 2Health News:Uses of medications in psychoanalysis 2
Designed to give maximum drying area while taking up minimal bench space....
Used to remove wrinkles from sections and for reorientating embedded tissue....
Compact instrument that quickly dries racks of slides using warm air....
Liquichek Blood Gas Plus CO-Oximeter Control (IL Synthesis Series) is a combination control for use in monitoring the performance of blood gas, ion-selective electrode, biosensor and CO-Oximetry anal...
Medicine Products: