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Novartis Tasigna(R) (nilotinib) Trial Shows Superior Results to Glivec(R) (imatinib) in Newly Diagnosed, Chronic Phase Chronic Myeloid Leukaemia
Date:12/8/2009

> All patients had a minimum of 12 months of treatment or discontinued early; the median follow-up was 14 months. Overall, 84%, 82% and 79% of patients remained in the study on nilotinib 300mg twice-daily, nilotinib 400mg twice-daily and imatinib 400mg once-daily, respectively.(1)

About Ph+ CML

CML is a disease in which the body produces cancerous (leukaemic) white blood cells. 95% of patients with CML have an abnormality known as the Philadelphia chromosome. This chromosome produces a protein called Bcr-Abl, which is responsible for the proliferation of leukaemic white blood cells in Ph+ CML.(3)

CML accounts for more than one in six leukaemias in adults, with around 600 new cases being registered in England and Wales each year.(2) The estimated prevalence of CML in 2003 in England and Wales was 2,660 patients.(2)

About Tasigna (nilotinib)

Nilotinib, a second generation TKI, is a potent and selective inhibitor of the Bcr-Abl protein, which is responsible for the proliferation of leukaemic white blood cells in Ph+ CML.(4,5) Nilotinib is indicated for the treatment of adults with chronic phase and accelerated phase Ph+ CML with resistance or intolerance to prior therapy including imatinib. Efficacy data in patients with CML in blast crisis are not available.(5)

For nilotinib summary of product characteristics, please see: http://emc.medicines.org.uk/medicine/20827/SPC/ Tasigna%20200%20mg%20hard%20capsules

(Due to the length of this URL, it may be necessary to copy and paste this hyperlink into your Internet browser's URL address field. Remove the space if one exists.)

About Glivec (imatinib)(7)

Imatinib is approved in the EU for the treatment of all phases of Ph+ CML. Imatinib is also indicated for the treatment of adult patients with Kit (CD 117)
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SOURCE Novartis Oncology
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