Navigation Links
Novartis Study Shows QTI571 Significantly Improved Walking Distance in Patients with Life-Threatening Pulmonary Arterial Hypertension
Date:9/25/2011

EAST HANOVER, N.J., Sept. 25, 2011 /PRNewswire/ -- Novartis announced new data today from the pivotal Phase III IMPRES clinical trial showing that the investigational therapy QTI571 (imatinib) significantly improved exercise capacity in patients with pulmonary arterial hypertension (PAH) after 24 weeks compared with placebo(1). Evidence indicates that QTI571 targets an underlying cause of PAH by counteracting uncontrolled growth of arterial smooth muscle cells(2).

The IMPRES study met its primary endpoint by demonstrating a significant improvement in the six-minute walk distance (6MWD) test in patients with elevated pulmonary vascular resistance (PVR) despite treatment with two or more specific PAH vasodilator therapies(1). The 6MWD is a predictor of survival in PAH patients(5,6), and is commonly used to assess exercise capacity in PAH clinical trials(7,8,9). In the study, patients treated with QTI571 increased their mean 6MWD by 31.8 meters compared with placebo (p=0.002)(1).

The study's secondary endpoints showed that QTI571 produced statistically significant improvements compared to placebo in pulmonary arterial pressure, cardiac output and pulmonary vascular resistance (all p<0.001)(1), but not in time to clinical worsening (i.e. death, hospitalization due to PAH, worsening of functional class, or >15% drop in 6MWD) (p=0.563)(1).

"These results are impressive as they were achieved in patients who were already receiving two or more established PAH drugs," said Marius Hoeper MD, Associate Professor, Department of Respiratory Medicine at Hannover Medical School, Germany and principal investigator of the IMPRES study. The data were presented for the first time at the European Respiratory Society (ERS) Annual Congress in Amsterdam, The Netherlands.

PAH is a debilitating disease of the heart and lungs that is characterized by a marked and sustained elevation in pulmonary artery pressure. The disease is chroni
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
2. Strength and Innovation of Novartis Oncology Products and Pipeline With Potential to Improve Patient Treatment Demonstrated by More Than 170 Abstracts at ASCO Annual Meeting
3. Emisphere Announces Recruitment of Novartis Phase III Study for Oral Osteoporosis Treatment
4. Video: Novartis Vaccines and PTA Battle Flu: Public Health Vaccination Initiative Urges Families Lets Fight Flu Together!
5. More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies
6. Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types
7. Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership
8. US FDA Approves Extavia(R) - the First in a New Portfolio of Planned MS Therapies from Novartis to Help Patients with this Devastating Disease
9. Results In The New England Journal Of Medicine Confirm Novartis Drug Femara(R) Is Superior To Tamoxifen After Breast Cancer Surgery
10. Novartis Enters Into Agreement for Exclusive US and Canadian Rights to Fanapt(TM), an FDA-Approved Oral Therapy for Schizophrenia
11. Novartis Pharmaceuticals Corporation Prevails in Medicaid Pricing Case Before Alabama Supreme Court
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 26, 2015 Research and Markets( http://www.researchandmarkets.com/research/ljsxt8/asia_pacific ) has ... Ray Devices Market - Growth, Trends And Forecasts (2014 - ... Asia Pacific market for Portable X-Ray ... 2014 to 2020 X-Ray is a form of ... the body, especially bones. The need of point of care ...
(Date:5/27/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/nt9zlx/asia_pacific ) has ... Market - Growth, Trends And Forecasts (2014 - 2019)" ... is a detailed type of imaging that customs a ... called a mammogram, is used to support in the ... An x-ray (radiograph) is a noninvasive medical test that ...
(Date:5/27/2015)... senior marketing associate with the animal health division of Eli Lilly and ... setting in Bangkok, Thailand , will be among the ... respect and dignity is the guiding star for me and my fellow ... LillyPad blog . Donatelli and Lilly colleagues from ... , France , Ukraine ...
Breaking Medicine Technology:Asia Pacific Portable X Ray Devices Market 2015 - Trends And Forecasts to 2019 2Asia Pacific Mammography Market Trends and Forecasts 2015-2019 2Lilly Sends Employees to Serve in Vulnerable Communities around the World 2Lilly Sends Employees to Serve in Vulnerable Communities around the World 3
(Date:5/27/2015)... Hills, CA (PRWEB) May 27, 2015 Khanna ... of the art web portal focussed on keratoconus eye ... This relentless progressive disease has its onset in the teenage ... down. The cornea or the front clear part of the ... the pressure in the eye. It results in poor vision ...
(Date:5/27/2015)... New York, New York (PRWEB) May 27, 2015 ... http://www.risperdallawsuit2014.com/ ) filed on behalf of individuals ... other complications related to the use of the ... mass tort litigation currently underway in Pennsylvania’s Philadelphia ... the litigation is proceeding with its bellwether trial ...
(Date:5/27/2015)... 27, 2015 In today's healthcare landscape, ... it can be challenging for doctors and hospitals to ... treatments. , Austin-based HealthTronics, Inc. is ... mobile medical therapies for clinically sophisticated applications. The company ... acquisition of Laser Ventures, Inc ., a mobile ...
(Date:5/27/2015)... NOVAtime Technology, Inc. ( http://www.novatime.com ), ... enterprise organizations, announced today that SanMar Corporation successfully ... time, attendance and point tracking processes for over ... States. , Family-owned since 1971, Seattle-based SanMar ... private label, and mill brands. SanMar supplies apparel ...
(Date:5/27/2015)... Little Rock, AR (PRWEB) May 27, 2015 ... and Medix today announce a partnership to provide ... the Medix community. This collaboration seeks to strengthen ... skills measurement through CMSA’s CKP program. The mutually ... focused on identifying individual skills of talent in ...
Breaking Medicine News(10 mins):Health News:KVI announced the launch of The Keratoconus website focused on age based keratoconus treatment . 2Health News:Risperdal Lawsuit Attorneys at Bernstein Liebhard LLP Look Forward to Start of Third Gynecomastia Bellwether Trial in Pennsylvania 2Health News:Risperdal Lawsuit Attorneys at Bernstein Liebhard LLP Look Forward to Start of Third Gynecomastia Bellwether Trial in Pennsylvania 3Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 2Health News:HealthTronics Invests in Additional Mobile Medical Technologies As Cost Efficient Solution for Hospitals, Doctors 3Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 2Health News:SanMar Corporation Successfully Implemented NOVAtime Workforce Management Solution across 9 locations 3Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 3
... PHOENIX, Jan. 10 NutraCea (OTC Bulletin,Board: ... bran (SRB), nutrient,research and technology, announced today ... HerbalScience Singapore Ltd Pte, a company that ... nutraceutical uses,and identifies novel chemistries for drug ...
... Inc. (AIM: TYR), the,pioneer of safer, effective ... achieved development and financial milestones from Arysta,LifeScience ... exclusive global,licensing and co-development agreement to manufacture ... certain horticultural markets., TyraTech is developing ...
... Plan of Care Module (ePOC) to Drive ... Enhanced Physician Customer Satisfaction, BERKELEY HEIGHTS, N.J., ... worldwide provider of secure workflow,management software and web-based services, today ... care organization, is,extending its use of the Inscrybe Healthcare platform ...
... VALLEY, Calif., Jan. 9 Synergy Life Science,Partners, ... investments,in emerging medical device technologies, today announced the ... an aggregate of $143,million in committed capital. The ... Founded in 2006 by John Onopchenko, Richard Stack, ...
... Her Battle ... with Hepatitis C, NEW YORK, Jan. ... advocating on behalf of,Americans with liver disease, is proud announce that it ... disease,including hepatitis C. To help spread the word about ALF,s work, EHE ...
... drugs are unregulated and could be dangerous, agency ... U.S. health officials warned Wednesday about so called ... popular alternative therapy among women with menopausal symptoms. ... said they,ve sent warning letters to seven pharmacies, ...
Cached Medicine News:Health News:NutraCea Forms Joint Ventures With HerbalScience to Develop Nutraceutical Extracts and Pharmaceutical Chemistries From Stabilized Rice Bran 2Health News:NutraCea Forms Joint Ventures With HerbalScience to Develop Nutraceutical Extracts and Pharmaceutical Chemistries From Stabilized Rice Bran 3Health News:NutraCea Forms Joint Ventures With HerbalScience to Develop Nutraceutical Extracts and Pharmaceutical Chemistries From Stabilized Rice Bran 4Health News:TyraTech Achieves Insecticide Development and Financial Milestones With Partner Arysta LifeScience 2Health News:TyraTech Achieves Insecticide Development and Financial Milestones With Partner Arysta LifeScience 3Health News:Advanced Home Care Extends Its Use of Authentidate's Inscrybe(TM) Healthcare Platform 2Health News:Advanced Home Care Extends Its Use of Authentidate's Inscrybe(TM) Healthcare Platform 3Health News:Advanced Home Care Extends Its Use of Authentidate's Inscrybe(TM) Healthcare Platform 4Health News:Synergy Life Science Partners Closes $143M Debut Medical Device Fund 2Health News:Synergy Life Science Partners Closes $143M Debut Medical Device Fund 3Health News:EHE International Supports the American Liver Foundation's Efforts at Raising Awareness for Hepatitis 2Health News:FDA Warns Against Bio-Identical Hormone Therapy 2Health News:FDA Warns Against Bio-Identical Hormone Therapy 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: