Navigation Links
Novartis Reports Omalizumab Significantly Improved Chronic Idiopathic Urticaria Symptoms in Patients Who Failed Standard Therapy
Date:2/24/2013

EAST HANOVER, N.J., Feb. 24, 2013 /PRNewswire/ -- Late-breaking results from ASTERIA II, a Phase III placebo-controlled study, showed positive results in patients with moderate to severe chronic idiopathic urticaria (CIU), referred to as chronic spontaneous urticaria (CSU) outside the United States, who remained symptomatic despite treatment with approved antihistamine doses. The data were published today in the New England Journal of Medicine and will be presented tomorrow at the American Academy of Allergy, Asthma & Immunology (AAAAI) annual meeting in San Antonio, Texas. Omalizumab is not indicated for CIU.

The primary endpoint was measured using a 21-point scale known as a weekly Itch Severity Score (ISS). The study met its primary endpoint, showing that omalizumab given at doses of 150 mg and 300 mg every four weeks led to significant improvement from baseline at Week 12 in the mean weekly ISS from baseline (approximately 14 in all treatment groups) by 8.1 (p=0.001) and 9.8 (p<0.001), respectively, compared to a 5.1 improvement in patients on placebo. The omalizumab 75 mg dose group did not demonstrate statistical significance compared to placebo for the primary endpoint. All eight pre-specified secondary endpoints in the ASTERIA II trial were met for the 150 mg and 300 mg doses, except for the 150 mg dose that did not show a significant difference from placebo in the proportion of angioedema-free days from Week 4 to Week 12 of therapy.

CIU is a distressing skin condition characterized by red, swollen, itchy and sometimes painful hives on the skin, spontaneously presenting and reoccurring for more than six weeks. At any given time, the prevalence of CIU is 0.5% to 1% worldwide. While antihistamines are used first to treat CIU, more than 50% of patients are unable to achieve symptom relief with approved doses.

"These results indicate that omal
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Novartis Pharma Logistics, Inc. voluntarily recalling in Jamaica select lots of certain over-the-counter products due to bottle closure defect
2. Novartis Pharma Logistics, Inc. voluntarily recalling in Trinidad & Tobago select lots of certain over-the-counter products due to bottle closure defect
3. Novartis Pharma Logistics, Inc. voluntarily recalling in Curacao select lots of certain over-the-counter products due to bottle closure defect
4. Novartis Pharma Logistics, Inc. voluntarily recalling in Aruba select lots of certain over-the-counter products due to bottle closure defect
5. Novartis Pharma Logistics, Inc. voluntarily recalling in Barbados select lots of certain over-the-counter products due to bottle closure defect
6. Continued Uptake of Novartis/Incytes Jakafi Will Be the Greatest Driver of Growth in the Myelofibrosis Therapy Market
7. Novartis highlights key data in patients with hematologic diseases and breast cancer with more than 140 abstracts at ASH and SABCS
8. Thesan Pharmaceuticals offentliggør første runde af venturefinansieringen ledt af Novo Ventures og Novartis Venture Funds i fællesskab
9. Thesan Pharmaceuticals annuncia un finanziamento di serie A co-gestito da Novo Ventures e Novartis Venture Funds
10. Thesan Pharmaceuticals gibt Serie-A-Finanzierung unter gemeinsamer Führung von Novo Ventures und Novartis Venture Funds bekannt
11. Thesan Pharmaceuticals Announces Series A Funding Co-Led By Novo Ventures And Novartis Venture Funds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... , Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... circulatory support therapies to save, support and restore failing ... upcoming investor conferences. On Tuesday, December 2, ... Annual Piper Jaffray Healthcare Conference.  D. Keith Grossman ... update on the company beginning at 11:30 a.m., Eastern ...
(Date:11/26/2014)... 26, 2014   Royal Philips (NYSE: ... expanded availability of its portfolio of diagnostic ... MobileDiagnost Opta[i] , ProGrade and PrimaryDiagnost[ii]. With new ... in the U.S., and availability of all these ... Philips, customers innovative solutions designed to meet the ...
(Date:11/26/2014)... , Nov. 26, 2014  Aethlon Medical, Inc. (OTCQB:AEMD), ... agreement to raise approximately $3.3 million at a price ... by one institutional healthcare focused investor. Each unit consists of ... common share purchase warrant. Each whole warrant entitles the ... of $0.30 for a period of five years from ...
Breaking Medicine Technology:Thoratec Announces Presentations At Investor Conferences For December 2014 2Philips expands global reach of diagnostic X-Ray solutions 2Philips expands global reach of diagnostic X-Ray solutions 3Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3
... on unmet needs of the lumbar ... ... CoreSpine Technologies, LLC, an,emerging spinal device company announced today the ... application,for minimally invasive fusion., The development of CoreSpine,s Technologies, initial ...
... Developer of Antibody Technologies to Strengthen Management Team, ... sheets: MNCN), a manufacturer and distributor of products,for animal ... Nash,Ph.D. as Chief Scientific Officer., In his new ... development activities in innovative antibody technologies for use in,the ...
Cached Medicine Technology:CoreSpine Technologies Expands Spinal Disc Site Preparation Efforts 2Dr. Peter Nash, Ph.D. Joins Mach One Corporation as Chief Scientist 2
(Date:11/26/2014)... The report “Laboratory Information System/LIS ... Hosted, SaaS), End User Labs (Clinical, Molecular Diagnostic, ... Services) - Global Forecast to 2019” provides a ... opportunities, current market trends, and strategies impacting the ... of the revenue and market growth. , Browse ...
(Date:11/26/2014)... 26, 2014 Increasing demand for ... image guided surgeries has paved way for consequent ... incidence of various types of cancers and cardiac ... in demand for these owing to their use ... media injectors market can also be attributed to ...
(Date:11/26/2014)... CA (PRWEB) November 26, 2014 Gone are ... after cheap deals on Black Friday, which signifies the beginning ... clicking items into their shopping carts in the comfort of ... , This Friday is going to be an ... a day, with an estimated $2.48 billion in revenue for ...
(Date:11/26/2014)... Angeles, CA (PRWEB) November 26, 2014 ... Angeles orthopedic surgeon Dr. Steven Meier has enhanced ... to offer current and prospective patients an online destination ... “We’re really excited to present the new and improved ... added features make it easier than ever for current ...
(Date:11/26/2014)... 2014 Sonru, the video interviewing specialist, ... Operating Officer and Chief Marketing Officer, in addition to ... , Jeff Jones has been appointed as Chief Operating ... the role of Chief Marketing Officer. , Mr Jones ... 25-year career includes senior roles with The Walt Disney ...
Breaking Medicine News(10 mins):Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 2Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 3Health News:Laboratory Information Systems Market by Type, Delivery Mode & End Users is Estimated to Reach $1,806.1 Million by 2019 - New Research Report by MarketsandMarkets 4Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 2Health News:Contrast Media Injectors Market To 2020 - Global Industry, Growth, Size, Share, Trends, Analysis And Forecast To 2020 Research Report By Grand View Research, Inc. 3Health News:2014 Best Friday Deals Revealed by Top10InAction 2Health News:Los Angeles Orthopedic Surgeon Dr. Steven Meier Announces Relaunch Of Practice Website 2Health News:Sonru Expansion continues with appointment of new executive team and opening of new London base 2
... of Canberra claim that they may have mastered the ... ,Positive parenting program was developed 2 years ago ... an intention to make parenting more pleasant. Minimizing stress ... was the aim. Researcher, Penny Sellers, who will develop ...
... the heir to the British throne has extended his generosity ... is in dire need of measures to get back the ... luncheon at Clarence House, his London residence, to launch an ... Kathmandu Valley, a chain of palaces and temples built by ...
... like angioplasty are the various treatments for people ... is a small industrial city in northeast Ohio. ... the country, would suggest their patients to go ... balloon catheters through arteries and sometimes placing drug-coated ...
... suspects were being interrogated by Deli Police in connection with ... in a car kidnapped a student of the Sarvodaya Kanya ... Place on Friday//. ,"We have registered a case of ... to arrest anyone," said Rameshwar Khatri, the station house officer ...
... Queensland's health system, the Australian Medical Association (AMA) has called ... Baker, AMA northern branch councilor, has said that Dr Bruce ... to improve the ailing system and added that Peter Beattie ... to health. ,He said "I think having a ...
... a man who immolated himself to protest against non-payment of ... approach// the National Human Rights Commission (NHRC) for justice. ... burns after setting fire to his clothes in front of ... company was not paying him his dues totaling Rs.200,000 ...
Cached Medicine News:Health News:Parenting skills to manage bad behaviour 2Health News:A Princely Assistance to the Nepal Heritage 2Health News:Heart Procedure numbers go haywire in an Ohio City 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: