Afinitor targets mTOR, a protein that acts as an important regulator of tumor cell division, blood vessel growth and cell metabolism(7). Preclinical and clinical data have established the role of mTOR in the development and progression of several types of tumors, including advanced pancreatic NET(1),(7).

About neuroendocrine tumors of pancreatic origin (pancreatic NET)Neuroendocrine tumors arise from cells that can produce and secrete a variety of hormones that regulate bodily functions(8). These tumors can occur anywhere in the body; however, most are found in the pancreas (pancreatic NET), gastrointestinal tract or lungs (carcinoid tumors)(6),(9). Pancreatic NET, also known as islet cell tumors, is a rare type of cancer different from pancreatic exocrine cancer, which is generally referred to as pancreatic cancer(3),(10). There have been limited treatment options for patients with pancreatic NET(2).