Navigation Links
Novartis Drug Afinitor® Effective in Patients With Non-Cancerous Kidney Tumors Associated With TSC in Phase III Trial
Date:9/23/2011

ignificant improvement in skin lesions including facial angiofibromas was observed, which can be a key concern for people living with TSC."  

Everolimus targets mTOR, a protein that acts as an important regulator of tumor cell division, blood vessel growth and cell metabolism(8). Tuberous sclerosis complex is caused by defects in the TSC1 and/or TSC2 genes(9). When these genes are defective, mTOR activity is increased, which can cause uncontrolled tumor cell growth and proliferation, blood vessel growth and altered cellular metabolism(2,9). By inhibiting mTOR activity in this signaling pathway, everolimus may reduce cell proliferation and blood vessel growth related to angiomyolipoma associated with TSC(2,8,9).

"The positive findings seen in this trial coupled with the known efficacy of everolimus in patients with SEGA point to the important role of mTOR inhibition with everolimus in treating these manifestations of TSC," said Herve Hoppenot, President, Novartis Oncology. "The outcomes support our further research efforts evaluating everolimus as a treatment option across the various conditions associated with TSC."

Affecting approximately 25,000 to 40,000 people in the US and one to two million people worldwide, TSC is associated with a variety of resulting disorders including skin lesions, seizures, swelling in the brain (hydrocephalus) and developmental delays(3,9).

About EXIST-2 EXIST-2 is a prospective, double-blind, randomized, parallel group, placebo-controlled, international, multicenter Phase III study of everolimus versus placebo for the treatment of patients with angiomyolipoma associated with TSC(1,10). Trial patients (median age=31, range 18-61) were randomized 2:1 to receive either everolimus (n=79) or placebo (n=39) at a daily starting dose of 10 mg. By the cut-off of June 30, 2011, the median treatment duration in the double-blind period was 38.1 weeks (range 2-105 weeks) in the everolimus arm and 3
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10

Related medicine technology :

1. Novartis Study Showed ACZ885 Provided Substantial Symptom Relief in 84% of Patients With the Most Serious Form of Childhood Arthritis
2. Phase III Trial of Novartis Drug Afinitor® Met Primary Endpoint of Reducing SEGA Tumor Size in Patients With Tuberous Sclerosis
3. Novartis Drug Gleevec® Shows Significant Overall Survival Benefit for Patients With GIST After Three Years of Adjuvant Treatment vs. One Year
4. Novartis highlights extensive data on numerous compounds at ASCO in multiple cancers, including Phase III studies in GIST and myelofibrosis
5. Novartis Data Shows ACZ885 for Severe Gouty Arthritis Provided Better Pain Relief and Reduced Risk of New Attacks by Up to 68% vs. Steroid
6. FDA Approves Novartis Drug Afinitor to Treat Pancreatic Neuroendocrine Tumors
7. Novartis Gains FDA Approval for Afinitor® as First New Treatment in Nearly Three Decades for Patients with Advanced Pancreatic NET
8. Novartis Drug Afinitor® Recommended by FDA Oncology Advisory Committee for Approval to Treat Advanced NET of Pancreatic Origin
9. US Supreme Court Denies Certiorari and Thereby Leaves in Place Second Circuit Ruling That Novartis Pharmaceuticals Corporation Must Pay its Sales Representatives Overtime Compensation
10. Novartis Gains FDA Approval for Amturnide™, a Triple-Combination Pill to Treat High Blood Pressure in Patients Uncontrolled on Two Medications
11. Study Shows Novartis Drug Afinitor® Plus Hormonal Therapy Delays Disease Progression in Advanced Metastatic Breast Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... , July 22, 2014 The National Space ... the Center for Space Radiation Research (CSRR) under the ... is an Associate Professor of Pharmaceutical Sciences within the ... Pharmacy Division of Radiation Health. She is located in ... direct a team of investigators working across four U.S. ...
(Date:7/22/2014)... 22, 2014  Decision Resources Group finds that ... patients currently treated with Biogen Idec,s oral ... flushing and/or gastrointestinal events while on the ... experiencing these side effects, signifying either their ... of such events. In the end, fewer ...
(Date:7/22/2014)... , July 22, 2014  Eyeon Therapeutics has ... eye treatment based on a charged hydrophilic polymer developed ... product has been shown to be safe and effective ... , MD, CEO states, "This first set of claims ... long way to moving this technology into the commercial ...
Breaking Medicine Technology:Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 2Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 3Particle Sciences and Eyeon Therapeutics Receive Patent on Novel Dry Eye Technology 2
... - Fralex Therapeutics Inc.,(TSX:FXI) ("Fralex" or the "Company"), ... today provided an update,on receiving results of the ... is investigating the use of Complex Neural Pulse ... associated with fibromyalgia., The Independent Data Monitoring ...
... from a 52-week phase 3,study (LEADTM 3) of ... once-daily,human GLP-1 analog, were published online today in ... alone, produces statistically,significant and sustained improvements in blood ... as compared with glimepiride, a widely used,oral anti-diabetic ...
Cached Medicine Technology:Fralex provides update on timing of interim analysis results 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 3
(Date:7/23/2014)... Hills, CA (PRWEB) July 23, 2014 ... 90 million Americans suffering from chronic bad breath that the ... whom they speak. , Dr. Saj Jivraj and Dr. Mamaly ... Woodland Hills, Calif., are concerned that some people may be ... breath often is a sign of an infection or chronic ...
(Date:7/23/2014)... QueenBeeTickets.com is reducing the prices of History of The Eagles ... who are still in the process of looking for concert ... use promo code “DISCOUNT” to get even lower prices than ... of discounted tickets at QueenBeeTickets.com. , The phenomenal band will ... The Eagles concert tickets literally disappearing across the country. The ...
(Date:7/23/2014)... 23, 2014 There is inherently nothing ... that it is healthy enough to react to specific ... “washing out” harmful toxins and bacteria from the body ... body just cannot do. , However, the social ... commonly known as “excessive sweating”—are serious: since sweating itself ...
(Date:7/23/2014)... Online medical service provider MeMD has appointed Dr. ... Dr. Lorenzo joins the MeMD executive team with over 25 ... part of this remote treatment model, telemedicine. This is the ... medical school, that someday we could treat people across the ... and it hasn't been that long,” says Dr. Lorenzo. , ...
(Date:7/23/2014)... viewed with suspicion as a New Age indulgence or ... business and arguably the most successful segment of health ... Die , award-winning journalists Fran Smith and Sheila Himmel ... their families. It’s the first book to take a ... of patients, caregivers and cutting-edge researchers, as well as ...
Breaking Medicine News(10 mins):Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 2Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 3Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 4Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 5Health News:History of The Eagles Tour Tickets: QueenBeeTickets.com Reduces Prices on Remaining Inventory of Concert Tickets for 2014 Shows 2Health News:Beat Your Sweating Demons Review | The Problem With Excessive Sweating and Solving it Naturally – Vinamy.com 2Health News:Beat Your Sweating Demons Review | The Problem With Excessive Sweating and Solving it Naturally – Vinamy.com 3Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 2Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 3Health News:Dealing with Loss: Library Journal Calls Changing the Way We Die an Essential Read 2
... hit Western Australia's south region with 50 cases being reported ... has also been // reported in the Territories with another ... ,Entomologist Nina Kurucz said that the pre-monsoon rains have ... is that this sort of mosquito can fly up to ...
... Professor Robin Simon and colleagues from Florida State University ... Behavior the reports of their study// conducted in ... had plans of not having children’s experienced less depression ... claims controversies views expressed by earlier researchers who had ...
... determining mental health status of an individual according to ... fatty food and compromise on fresh food such as ... memory related problems. Moreover, implementation of diet changes was ... than conventional approaches such as drug treatment or counseling. ...
... to treat breast cancer reduces the radiation time from six weeks ... it is less convenient. Doctors// can point the radiation ... study compares the usefulness of the new therapy over the conventional ... suitable subjects for this therapy. ,But the Canadians are ...
... a workshop on Islamic Medical Ethics new rules and ... was attended by national and international physicians who wanted ... Malika Haque, Clinical Professor Pediatrics, Ohio State University and ... several new ethical laws. ,They said ...
... Jong S. Kim and his colleagues from Asan medical ... drug Prozac is found effective in treating emotional stress ... conducted their study in 152 patients who were given ... months and the results found that the study patients ...
Cached Medicine News:Health News:Diet Can Influence Your Mental Health As Well 2
Velcro closures on each side to more evenly distribute the weight. Available in teal, royal, red, purple, or maroon nylon stain-resistant fabric or navy nylon reinforced vinyl....
Our quick release buckle apron is user friendly and our large support straps criss-crossing the back allows proper placement of the belt at your waist. Built-in shoulder pads add to the comfort....
An economical solution to the need to provide wrap-around protection. The one-sided velcro closure allows greater flexibility in sizing. Front protection is 0.5mm Pb and the back is 0.25mm Pb equival...
The most comfortable and easy to use apron in the industry. This front protection apron comes with a fully adjustable snap-on 5" orthopedic belt to relieve weight off your shoulders. Velcro strap acr...
Medicine Products: