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Novartis Data Shows ACZ885 for Severe Gouty Arthritis Provided Better Pain Relief and Reduced Risk of New Attacks by Up to 68% vs. Steroid
Date:5/24/2011

l tolerated in the two studies. In one study, 55.8% of patients had adverse events (AEs) with ACZ885 vs. 38.3% with TA(16). In the other study, 54.5% of patients had AEs with ACZ885 vs. 50.9% with TA(17). Serious adverse events (SAEs), 10 for ACZ885 vs. five for TA in one study and three for ACZ885 vs. one for TA in the other study, were not considered to be related to study medication by the investigators(16,17).

About ACZ885ACZ885 is a fully human monoclonal antibody that inhibits interleukin-1 beta (IL-1 beta), which is part of the body's immune system defenses(19). Excessive production of IL-1 beta plays a major role in many inflammatory diseases, including gouty arthritis(19). ACZ885 works by neutralizing IL-1 beta for a sustained period of time, therefore inhibiting inflammation(10).

DisclaimerThe foregoing release contains forward-looking statements that can be identified by terminology such as "may", "will", "committed", "potential" or similar expressions, or by express or implied discussions regarding potential new indications or labeling for ACZ885 or regarding potential future revenues from ACZ885. You should not place undue reliance on these statements.  Such forward-looking statements reflect the current views of management regarding future events, and involve known and unknown risks, uncertainties and other factors that may cause actual results with ACZ885 to be materially different from any future results, performance or achievements expressed or implied by such statements. There can be no guarantee that ACZ885 will be approved for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that ACZ885 will achieve any particular levels of revenue in the future. In particular, management's expectations regarding ACZ885 could be affected by, among other things, unexpected regulatory actions or delays or government regulation generally; unexpected clinical trial results, incl
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