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Novan's SB204 Could Be First Topical Sebum Inhibitor
Date:2/28/2013

DURHAM, N.C., Feb. 28, 2013 /PRNewswire/ -- Novan Therapeutics, a clinical-stage drug development company, today announced in vitro and animal testing data indicating that the company's drug candidate, SB204, could lead to a topical treatment to reduce oil production in the skin.  SB204 is being developed as a new therapy for acne which is the most common skin disease in the United States, affecting more than 50 million people. 

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None of the current topical products approved by the FDA reduce the production of sebum, the oily/waxy secretions of the skin.  Dr. Diane Thiboutot , Professor of Dermatology at Penn State Hershey College of Medicine, believes "Inhibiting the production of sebum is critical to affecting the acne disease process.  Orally administered therapies that can reduce oily secretions of the skin have traditionally shown good clinical responses.  At this time, I am not aware of any topically applied therapy that can reduce sebum production."

Novan-sponsored research conducted in the lab of Dr. Thiboutot revealed that nitric oxide-releasing compounds could reduce sebum production in vitro using immortalized human sebocytes.  The study results demonstrated that Novan's drug candidate showed a statistically significant decrease in insulin-induced lipid production as early as 24 hours after a single treatment.   

In a separate study to further expand upon the company's unique discovery, topical application of nitric oxide-releasing SB204 inhibited the growth of a hamster flank organ by more than 50% compared to vehicle control.  "We are really excited about these results because this now gives us two potential pathways by which SB204 can shut down the production of seb
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SOURCE Novan Therapeutics
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