Navigation Links
Novan's SB204 Could Be First Topical Sebum Inhibitor
Date:2/28/2013

DURHAM, N.C., Feb. 28, 2013 /PRNewswire/ -- Novan Therapeutics, a clinical-stage drug development company, today announced in vitro and animal testing data indicating that the company's drug candidate, SB204, could lead to a topical treatment to reduce oil production in the skin.  SB204 is being developed as a new therapy for acne which is the most common skin disease in the United States, affecting more than 50 million people. 

(Logo: http://photos.prnewswire.com/prnh/20130228/NE68367LOGO )

None of the current topical products approved by the FDA reduce the production of sebum, the oily/waxy secretions of the skin.  Dr. Diane Thiboutot , Professor of Dermatology at Penn State Hershey College of Medicine, believes "Inhibiting the production of sebum is critical to affecting the acne disease process.  Orally administered therapies that can reduce oily secretions of the skin have traditionally shown good clinical responses.  At this time, I am not aware of any topically applied therapy that can reduce sebum production."

Novan-sponsored research conducted in the lab of Dr. Thiboutot revealed that nitric oxide-releasing compounds could reduce sebum production in vitro using immortalized human sebocytes.  The study results demonstrated that Novan's drug candidate showed a statistically significant decrease in insulin-induced lipid production as early as 24 hours after a single treatment.   

In a separate study to further expand upon the company's unique discovery, topical application of nitric oxide-releasing SB204 inhibited the growth of a hamster flank organ by more than 50% compared to vehicle control.  "We are really excited about these results because this now gives us two potential pathways by which SB204 can shut down the production of seb
'/>"/>

SOURCE Novan Therapeutics
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. New Report: Drugstore Networks Could Save Employers, Medicare, and Medicaid $115 Billion
2. Breakthrough Research Could Create Sea Change in Global HIV Diagnosis: New Handheld Mobile Device Performs Laboratory-Quality HIV Testing
3. Pen Pals, Glowing Parasites & Crop Camouflage Could Help Improve Lives
4. Back to School Ideas: Vaccines for Kids Could Hurt Rather Than Help Fight Disease
5. HIV Immunity Study Could Pave Way for Vaccine Development
6. Hearing Loss Could Lead to Multiple Chronic Diseases for Millions of Brits
7. Ochsner Implants First Total Artificial Heart In The Gulf South Region
8. London Health Sciences Centre Announces Firsts in Treatment Option for Blood Circulation
9. Ixonos auttaa Firstbeatia parantamaan syketallentimensa suorituskykyä ja helppokäyttöisyyttä
10. Ixonos Helps Firstbeat to Boost the Performance and Usability of Their Heart Beat Recording Device
11. New Bioterrorism Vaccine Gets First Test In Humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... , March 27, 2015  The quality function within ... ensure products meet quality standards at every stage of ... regulations, quality leaders also have the challenge of balancing ... Those who don,t effectively balance these priorities risk ... as marketplace failure and regulatory scrutiny. For ...
(Date:3/27/2015)... /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, OTCQB:MCUJF) announces ... grant of an aggregate of 236,070 options to certain ... the Company pursuant to the Company,s Stock Option Plan. ... the tenth anniversary of the date of grant, 5,000 ... the date of grant and 50,000 are set to ...
(Date:3/27/2015)... , March 27, 2015 Biopharmaceutical Industry ... biopharmaceutical industry comes out on top as the country,s ... new report  from ndp│analytics. According to the  analysis ... (R&D) investment over the last decade, accounting for 27 ... A Short Video on Medicare Part ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2Week in Review: The Latest from PhRMA 2
... SHENZHEN, China , May 6 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain,Drugstore Ltd. ... in China based on the number of directly operated stores,announced today ... March 31, 2010 , before the market opens on, Wednesday, May 19, ... ...
... SCOLR Pharma, Inc. (NYSE AMEX: DDD ... Agreement with RedHill Biopharma Ltd. an Israeli corporation, (RedHill), ... ondansetron tablet formulations based on SCOLR,s proprietary extended delivery ... Zofran®, GlaxoSmithKline,s drug to prevent chemotherapy and radiation related ...
Cached Medicine Technology:China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 2China Nepstar Chain Drugstore Reports First Quarter 2010 Results on May 19 3SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 2SCOLR Pharma, Inc. Enters into Worldwide Licensing Agreement with RedHill Biopharma Ltd. 3
(Date:3/28/2015)... New York, NY (PRWEB) March 28, 2015 ... clinic that offers urgent care in Manhattan, recently commemorated ... urgent care facility in Manhattan. In addition to 24-hour ... to ER facilities. , At this time, Emergency ... treatments for abdominal pain, asthma, chest pain, eye injuries, ...
(Date:3/28/2015)... 28, 2015 Pitching speed, player’s height, and ... shoulder and elbow injuries, according to new research released today ... ) Specialty Day. , “Our findings indicate that a 10 ... in likelihood of a history of injury, a 10 mile ... increase likelihood of a history of injury, and playing for ...
(Date:3/28/2015)... 2015 Early surgery may not be ... AC joint injuries, according to new research from Tripler ... American Orthopaedic Society for Sports Medicine’s ( AOSSM ) ... when surgery was not performed. , The final study ... treatment and 17 receiving non-surgical therapy. Of the non-surgery ...
(Date:3/28/2015)... Omaha, NE (PRWEB) March 28, 2015 ... leader in healthcare staffing, including physical therapy jobs, ... exhibitor at the Ohio Physical Therapy Association Annual ... the Renaissance Columbus Downtown Hotel in Columbus, OH. ... programming, networking opportunities, and exhibits with products and ...
(Date:3/28/2015)... ARDX will sponsor the 7th Annual Women’s Wellness ... Chesapeake Conference Center in Chesapeake, Virginia. Each year, ARDX ... women in the Hampton Roads region. The 2015 Women’s ... Women grow stronger through sharing their stories and learning ... the WWC™ theme is T-talk where we will share a ...
Breaking Medicine News(10 mins):Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the Ohio Physical Therapy Association Annual Conference 2
... ... wife and husband team of doctors, is a finalist in the Sixth Annual ... technologies, and Epocrates, the premier provider of medical decision support tools for doctors ... health blog until midnight Sunday, February 14. , ...
... ... Implementation of New Infrastructure Technologies. , ... (PRWEB) December 11, 2009 -- Data Strategy, a trusted leader of ... that helps customers evaluate the benefits of deploying Avamar deduplication backup software. SurePath ...
... , , CHICAGO , Feb. 11 ... a life-saving gift this Valentine,s Day by declaring disease-causing E. ... for them.   E. coli O157:H7 was declared ... the west coast outbreak that sickened over 700 people and killed ...
... , WESTPORT, Conn. , Feb. 11 ... resident and Zeta Interactive CEO, Al DiGuido , announced ... this evening from Aitoro,s Appliances in Norwalk, CT . , ... 2010, will feature live entertainment and dancing, top-quality dining from several ...
... , , NORFOLK, Va. Feb. 11 ... piloted his Cessna 208 Caravan to Santo Domingo, Dominican ... remarkable airlift of Operation Smile medical volunteers and supplies into Hinche, ... Mr. Ford decided to volunteer his time, piloting skills and aircraft ...
... study finds , THURSDAY, Feb. 11 (HealthDay News) -- A ... discharge a patient who has come to the emergency room ... artery calcium scoring (CACS) test detects coronary artery disease. A ... detailed image of the heart that shows calcium build-up in ...
Cached Medicine News:Health News:CelebrityDiagnosis.com Nominated as Best New Medical Blog of 2009 2Health News:CelebrityDiagnosis.com Nominated as Best New Medical Blog of 2009 3Health News:Data Strategy Announces SurePath Services Offering for EMC Avamar 2Health News:Data Strategy Announces SurePath Services Offering for EMC Avamar 3Health News:Six Other E. coli's Could Be Lurking In Your Valentine Day's Dinner 2Health News:Al's Angels' 'Love and Laughter' Event to Support Children and Families in Desperate Need 2Health News:Al's Angels' 'Love and Laughter' Event to Support Children and Families in Desperate Need 3Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 2Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 3Health News:Actor and Humanitarian Harrison Ford Assists Operation Smile's Relief Efforts in Haiti 4
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: