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Novan Announces Promising Results of SB204 Clinical Study
Date:5/30/2013

DURHAM, N.C., May 30, 2013 /PRNewswire/ -- Novan Therapeutics, today announced results from a recent clinical trial demonstrating that nitric oxide releasing drug candidate SB204 reduces colonization of the acne causing bacteria Propionibacterium acnes (P. acnes)  in the skin of healthy volunteers.  This study in combination with Novan's earlier findings regarding sebum production, suggests the formulation may be capable of targeting multiple factors in acne.

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The Phase 1, 30-subject study was conducted by Dr. James Leyden (KGL, Inc.). This predictive human model has been used to demonstrate the activity of anti-acne therapies like traditional oral antibiotics and topical antibiotics such as clindamycin.  In this study, twice daily administration of the topical product was safe and "the treatment was extremely well tolerated," added Dr. Leyden.  Several subjects demonstrated a greater than 90 percent reduction of P. acnes when treated with SB204; no vehicle-treated subjects exhibited such a response.  A statistically significant difference (p < 0.05) in P. acnes counts was observed between active and vehicle after two weeks.

Acne is the most common skin disease in the United States, affecting more than 50 million people.  Antibiotics have been a mainstay for dermatologists due to the ability to reduce P. acnes colonization in the skin and the documented ability to treat inflammatory lesions in acne patients.  However, monotherapy usage of these drugs has slowed due to the onset of antibiotic resistance.  Nitric oxide is an antimicro
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SOURCE Novan Therapeutics
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