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Nova Southeastern University Researchers Receive $4.1 Million Grant from Department of Defense to Investigate Gulf War Illness
Date:11/19/2013

normal immune, cardiovascular, and hormone signaling.

However, the exact cause of this disruption is not well understood. The goal of the consortium is to pinpoint the causes of GWI using a multidisciplinary approach. The project will involve integrating basic and clinical research using a computational systems biology method to correlate data between the physiological compartments and levels of biology from basic models to human patients. This will allow them to tailor treatment more effectively using drugs already approved for other illnesses.

At the end of the four-year study, the consortium plans to complete early studies in human patients and be able to pursue larger-scale clinical trials for further drug testing.

"By increasing the understanding of the reasons for GWI, our consortium will advance the diagnosis and treatment of the disease," said Morris. "Specifically, our more detailed understanding of the dysfunction involved in GWI would greatly increase the speed to identify targets for improved diagnosis as well as selection and testing of more specific treatments over the longer term that will address the causes of disease."

The consortium consists of co-principal investigators Mariana Morris, Ph.D., NSU professor and director of Gulf War research, and Nancy Klimas, M.D., director of NSU COM's Institute for Neuro Immune Medicine; Gordon Broderick, Ph.D., NSU Center for Psychological Studies; Travis Craddock, Ph.D., assistant professor, NSU Center for Psychological Studies; NSU-COM's Institute for Neuro Immune Medicine genomics core, and Mary Ann Fletcher, Ph.D., NSU-COM's Schemel Professor for Neuro Immune Medicine. The team is affiliated with the research service of the Bruce W. Carter Department of Veterans Affairs Medical Center and Miami VA Healthcare System. Klimas is also affili
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